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Demenz pp 87–95Cite as

Energiestoffwechsel und Neurotransmittersynthese im Gehirn bei Demenz vom Alzheimer-Typ

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Zusammenfassung

Vor nahezu 50 Jahren konnte erstmals gezeigt werden, daß der oxidative Stoffwechsel des Gehirns unter physiologischen Bedingungen ausschließlich auf der Nutzung von Glukose als Substrat der Energiegewinnung basiert [13]. Spätere Untersuchungen haben diesen Befund bestätigt und zudem dem zerebralen Glukose- und Energiestoffwechsel eine zentrale Stellung bei der Aufrechterhaltung normaler mentaler Funktionen zugewiesen [7,10,17, 19, 44], Aus Glukose werden im Gehirn der Neurotransmitter Acetylcholin [35] und die Aminosäurenneurotransmitter Glutamat, Aspartat, Glyzin und γ-Aminobuttersäure gebildet [2,40,56]. Glutamat und Aspartat haben exzi-tatorische, Glyzin und γ-Aminobuttersäure inhibitorische Wirkungen. Allein diese Beispiele verdeutlichen, daß eine Störung im zerebralen Glukosestoffwechsel zu erheblichen Beeinträchtigungen im Energie- und Neuro-transmitterhaushalt dieses Organs und damit zu mentalen Leistungseinbußen führen muß. Am Beispiel der Demenz vom Alzheimer-Typ sollen derartige pathobiochemische Vorgänge im Gehirn erläutert werden.

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  1. S. Hoyer
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Editors and Affiliations

  1. Psychiatrischen Klinik mit Poliklinik, Universität Erlangen-Nürnberg, Schwabachanlage 6-10, D-8520, Erlangen, Deutschland

    Eberhard Lungershausen (Direktor) (Direktor)

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© 1992 Springer-Verlag Berlin Heidelberg

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Hoyer, S. (1992). Energiestoffwechsel und Neurotransmittersynthese im Gehirn bei Demenz vom Alzheimer-Typ. In: Lungershausen, E. (eds) Demenz. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76932-0_11

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  • DOI: https://doi.org/10.1007/978-3-642-76932-0_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76933-7

  • Online ISBN: 978-3-642-76932-0

  • eBook Packages: Springer Book Archive

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