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L-Glutamate Decarboxylase Immunoreactivity in the Sympathoadrenal System

  • Conference paper
GABA Outside the CNS

Abstract

The role of GABA as an inhibitory neurotransmitter in the mammalian brain has been well established. In recent years, increasing evidence has been presented to show that GABA may act as a neurotransmitter also in parts of the peripheral nervous system [20, 21, 51]. In the myenteric plexus of the gut an autonomic neurotransmitter role for GABA has been proposed by several authors [29–32], In sympathetic ganglia, a specific GABA uptake system [11, 62], GABA receptors [12, 13], and the depolarizing effect of GABA on sympathetic neurons [1, 12, 13] have been described in previous studies. The presence of GABA and the GABA-synthesizing enzyme L-glutamate decarboxylase (GAD) in sympathetic ganglia was also shown by biochemical [8, 33, 55] and, recently, immunohistochemical methods [14, 15, 24–28, 34, 35, 38, 44, 57, 58]. Studies have now been carried out in order to investigate the expression and distribution of GAD in the developing sympathoadrenal system and to further analyze the presence and localization of GAD in different parts of the sympathetic nervous system.

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Authors
  1. O. Häppölä
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  2. T. Karhula
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  3. H. Päivärinta
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  4. S. Soinila
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  5. J.-Y. Wu
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  6. M. Ahonen
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Editor information

Editors and Affiliations

  1. Department of Anatomy, University of Göttingen, Kreuzbergring 36, W-3400, Göttingen, Germany

    Sándor L. Erdö Ph.D.

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© 1992 Springer-Verlag Berlin Heidelberg

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Häppölä, O., Karhula, T., Päivärinta, H., Soinila, S., Wu, JY., Ahonen, M. (1992). L-Glutamate Decarboxylase Immunoreactivity in the Sympathoadrenal System. In: Erdö, S.L. (eds) GABA Outside the CNS. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76915-3_5

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  • DOI: https://doi.org/10.1007/978-3-642-76915-3_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76917-7

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