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GABA Outside the CNS pp 277–293Cite as

GABAergic Mechanisms and Modulation of the Anaphylactic Response

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Abstract

It is well known than the anaphylactic reaction can be affected by various neurotransmitters. Furthermore, exocytie processes following challenge with antigen can be modulated due to the presence of different neurotransmitter receptors located on the membranes of involved sensitized cells [23, 22]. GABA, through GABAA and GABAB receptors, appears to have a peculiar role as a neuromodulator in the neuro-vegetative system, since it can inhibit or facilitate the release of classical neurotransmitters such as acetylcholine (ACh), norepinephrine (NE) or peptides (for comprehensive and recent reviews see [5, 7]). Thus, the possibility that GABA could interfere with anaphylaxis arose, and this has been the object of our study, performed in in vivo and in vitro models. We have shown that GABAergic drugs can exert a protective effect against allergic bronchospasm in actively sensitized guinea-pigs [20] and in the Schultz-Dale reaction in isolated tissues [33].

This work was supported by a grant from the University of Florence.

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Authors
  1. L. Zilletti
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  2. M. Ciufi
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  3. S. Franchi-Micheli
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  4. G. Gentilini
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Editor information

Editors and Affiliations

  1. Department of Anatomy, University of Göttingen, Kreuzbergring 36, W-3400, Göttingen, Germany

    Sándor L. Erdö Ph.D.

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© 1992 Springer-Verlag Berlin Heidelberg

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Zilletti, L., Ciufi, M., Franchi-Micheli, S., Gentilini, G. (1992). GABAergic Mechanisms and Modulation of the Anaphylactic Response. In: Erdö, S.L. (eds) GABA Outside the CNS. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76915-3_20

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  • DOI: https://doi.org/10.1007/978-3-642-76915-3_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76917-7

  • Online ISBN: 978-3-642-76915-3

  • eBook Packages: Springer Book Archive

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