GABAergic Mechanisms and Modulation of the Anaphylactic Response
It is well known than the anaphylactic reaction can be affected by various neurotransmitters. Furthermore, exocytie processes following challenge with antigen can be modulated due to the presence of different neurotransmitter receptors located on the membranes of involved sensitized cells [23, 22]. GABA, through GABAA and GABAB receptors, appears to have a peculiar role as a neuromodulator in the neuro-vegetative system, since it can inhibit or facilitate the release of classical neurotransmitters such as acetylcholine (ACh), norepinephrine (NE) or peptides (for comprehensive and recent reviews see [5, 7]). Thus, the possibility that GABA could interfere with anaphylaxis arose, and this has been the object of our study, performed in in vivo and in vitro models. We have shown that GABAergic drugs can exert a protective effect against allergic bronchospasm in actively sensitized guinea-pigs  and in the Schultz-Dale reaction in isolated tissues .
KeywordsHistamine Release Myenteric Plexus GABAB Receptor Gaba Inhibition GABAergic Mechanism
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