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GABA Outside the CNS pp 215–232Cite as

GABA Receptors Inside and Outside the Brain

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Abstract

Establishment of any substance as a neurotransmitter or neurohormone requires the fulfillment of defined criteria [56]; this is often easier outside than inside the brain. However, the reverse appears to be true for γ-aminobutyric acid (GABA). Evidence for its localized presence and discrete release from neuronal processes has been demonstrated in brain tissue and inhibitory neuronal responses to exogenous GABA compare favourably with the synaptic response to Stimulation of inhibitory pathways [45, 24]. The significance of GABA in these mechanisms is substantiated by the use of selective antagonists such as bicuculline and 2-hydroxysaclofen or phaclofen [22, 32, 38], which substantially block synaptically mediated responses including that to applied GABA.

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Authors
  1. N. G. Bowery
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Editors and Affiliations

  1. Department of Anatomy, University of Göttingen, Kreuzbergring 36, W-3400, Göttingen, Germany

    Sándor L. Erdö Ph.D.

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© 1992 Springer-Verlag Berlin Heidelberg

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Bowery, N.G. (1992). GABA Receptors Inside and Outside the Brain. In: Erdö, S.L. (eds) GABA Outside the CNS. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76915-3_15

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  • DOI: https://doi.org/10.1007/978-3-642-76915-3_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76917-7

  • Online ISBN: 978-3-642-76915-3

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