The GABAergic System in Human Female Genital Organs

  • Á. László
  • G. L. Nádasy
  • E. Monos
  • B. Zsolnai
  • S. L. Erdö


It has been recently shown that γ-aminobutyric acid (GABA) and its related enzymes, i.e., glutamate decarboxylase (GAD) and GABAtransaminase (GABA-T), are present in the female genitale tract of various mammals at higher levels than in most other organs, at least in the rat (for reviews see [13, 16, 35, 47, 60, 64]).


GABAB Receptor Gaba Level Gaba Concentration GABAergic System Gaba System 
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  1. 1.
    Amenta F, Cavallotti C, Mione MC, Erdö SL (1986) Segmental distribution and gestational changes of GABA-transaminase activity in rat oviduct. J Reprod Fertil 78: 593–599PubMedCrossRefGoogle Scholar
  2. 2.
    Andersson AC, Henningsson S (1980) In vitro metabolism of putrescine by diamine oxidase in tissues of the pregnant rat. Agents Actions 10: 104–106PubMedCrossRefGoogle Scholar
  3. 3.
    Andersson AC, Henningsson S, von Scheele C (1980) Formation of GABA via oxidative deamination of putrescine in ovaries of immature rats after gonadotrophin Stimulation. Agents Actions 10: 106–107PubMedCrossRefGoogle Scholar
  4. 4.
    Apud JA, Tappaz ML, Celotti F, Negri-Cesi P, Masotto C, Racagni G (1984) Biochemical and immunochemical studies on the GABAergic system in the rat fallopian tube and ovary. J Neurochem 43: 120–125PubMedCrossRefGoogle Scholar
  5. 5.
    Bowery NG, Doble A, Hill DR, Hudson AI, Shaw JS, Turnbull MJ, Warrington R (1981) BicucuIIine-insensitive GABA receptors on peripheral autonomic nerve terminals. Eur J Pharmacol 71: 53–70PubMedCrossRefGoogle Scholar
  6. 6.
    Bowery NG, Hill DR, HudsonAL(1983) Characteristics of GABAB receptor binding sites on rat whole brain synaptic membranes. Br J Pharmacol 78: 191–206PubMedGoogle Scholar
  7. 7.
    Bowery NG, Price GW, Hudson AL, Hill DR, Wilkin GP, Turnbull MJ (1984) GABA receptor multiplicity. Visualization of different receptor types in the mammalian CNS. Neuropharmacology 23: 219–231PubMedCrossRefGoogle Scholar
  8. 8.
    Celotti F, Apud JA, Rovescaili AC, Melcangi RC, Negri-Cesi P, Racagni G (1986) The GABAergic extrinsic innervation of the rat follopian tubes: biochemical evidence and endocrine modulation. Adv Biochem Psychopharmacol 42: 251–264PubMedGoogle Scholar
  9. 9.
    Celotti F, Apud JA, Rovescaili AC, Negri-Cesi P, Racagni G (1987) Possible involvement of ovarian mechanisms other than estrogen-progesterone secretion in the regulation of glutamic acid decarboxylase activity of the rat fallopian tubes. Endocrinology 120: 700–706PubMedCrossRefGoogle Scholar
  10. 10.
    Eldefrawi AT, Eldefrawi ME (1987) Receptors for Y - aminobutyric acid and voltage dependent Chloride Channels as targets for drugs and toxicants.Google Scholar
  11. 11.
    Erdö SL (1984) Identification of GABA receptor binding sites in rat and rabbit uterus. Biochem Biophys Res Commun 125: 18–24PubMedCrossRefGoogle Scholar
  12. 12.
    Erdö SL (1984) Alteration of GABA levels in ovary and fallopian tube of the pregnant rat. Life Sei 34: 1879–1884CrossRefGoogle Scholar
  13. 13.
    Erdö SL (1985) Peripheral GABAergic mechanisms. Trends Pharmacol Sei 6: 205–208CrossRefGoogle Scholar
  14. 14.
    Erdö SL (1986)GABAergic mechanisms and their possible role in the oviduct and uterus. In: Erdö SL, Bowery NG. (eds) GABAergic mechanisms in the mammalian periphery. Raven, New York, pp 205–217Google Scholar
  15. 15.
    Erdö SL, Amenta F (1986) Characterization and localization of high-affinity GABA uptake in slices of the rabbit oviduct. Eur J Pharmacol 130: 287–294PubMedCrossRefGoogle Scholar
  16. 16.
    Erdö SL, Bowery NG. (eds) (1986) GABAergic mechanisms in the mammalian periphery. Raven, New YorkGoogle Scholar
  17. 17.
    Erdö SL, Lapis E (1982) Presence of GABA receptors in rat oviduct. Neurosci Lett 33: 257–279CrossRefGoogle Scholar
  18. 18.
    Erdö SL, Lapis E (1982) Bicuculline-sensitive GABA receptors in rat ovary. Eur J Pharmacol 85: 242–246CrossRefGoogle Scholar
  19. 19.
    Erdö SL, László Á (1984) High specific gamma-aminobutyric acid binding to membranes of the human ovary. J. Neuorchem 42: 1464–1467CrossRefGoogle Scholar
  20. 20.
    Erdö SL, Rosdy B, Szporny L (1982) Higher GABA concentrations in fallopian tube than in brain of the rat. J Neurochem 38: 1174–1176PubMedCrossRefGoogle Scholar
  21. 21.
    Erdö SL, László A, Szporny L, Zsolnai B (1983) High density of specific GABA binding sites in the human fallopian tube. Neurosci Lett 42: 155–160PubMedCrossRefGoogle Scholar
  22. 22.
    Erdö SL, Riesz M, Karpäti M, Szporny L (1984) GABAB-receptor mediated Stimulation of the contractility of isolated rabbit oviduct. Eur J Pharmacol 99: 333–336PubMedCrossRefGoogle Scholar
  23. 23.
    Erdö SL, Kiss B, Szporny L (1984) Comparative characterization of glutamate decarboxylase in crude homogenates of oviduct, ovary, and hypothalamus. J Neurochem 43: 1532–1537PubMedCrossRefGoogle Scholar
  24. 24.
    Erdö SL, LászlóA, KissB, ZsolnaiB(1985) Presence of gamma-aminobutyric acid and its specific receptor binding sites in the human term placenta. Gynecol Obstet Invest 20: 199–203PubMedCrossRefGoogle Scholar
  25. 25.
    Erdö SL, Varga B, Horváth E (1985) Effect of local GABA administration on rat ovarian blood flow, and on progesterone and estradiol secretion. Eur J Pharmacol 11: 397–400CrossRefGoogle Scholar
  26. 26.
    Erdö SL, Somogyi J, Hámori J, Amenta F (1986) Light- and electronmicroscopic visualization of gama-aminobutyric acid and GABA-transaminase in the oviduct of rats. Predominant occurence in epithelium. Cell Tissue Res 244: 621–626Google Scholar
  27. 27.
    Erdö SL, Villányi P, László Á (1989) Gestational changes of GABA levels and GABA binding in the human uterus. Life Sei 44: 2009–2014CrossRefGoogle Scholar
  28. 28.
    Erdö SL, Joó F, Wolff JR (1989) Immunohistochemical localization of glutamate decarboxylase in the rat oviduct and ovary: further evidence for non-neuronal GABA systems. Cell Tissue Res 255: 431–434PubMedCrossRefGoogle Scholar
  29. 29.
    Ferkany JW, Smith LA, Seifert WE, Caprioli RM, Enna SJ (1978) Measurement of gamma-aminobutyric acid (GABA) in blood. Life Sei 22: 2121–2128CrossRefGoogle Scholar
  30. 30.
    FernándezI, OrensanzLM, de CeballosML(1984) GABA modulation of cholinergic transmission in rat oviduct. Life Sei 35: 357–364CrossRefGoogle Scholar
  31. 31.
    Fernandez-Pardal J, Gimeno MF, Gimeno AL (1984) The presence of GABA in ovarian, tubal and uterine rat tissue and the influence of estrogens. IRCS Med Sei 12: 706Google Scholar
  32. 32.
    Gimeno MF, Fernandez-Pardal J, Viggiano M, Pezzot MC, Gimeno AL (1986) On the presence of GABA in ovarian, tubal and uterine rat tissues. Modification at different stages of the estrous cycle and during pregnancy. Adv Biochem Psychopharmacol 42: 275–282PubMedGoogle Scholar
  33. 33.
    Grandison L, Cavagnini F, Schmid R, Invitti C, Guidotti A (1982) γ-Aminobutyric acid- and benzodiazepine-binding sites in human anterior pituitary tissue. J Clin Endocrinol Metab 54: 597–601PubMedCrossRefGoogle Scholar
  34. 34.
    Grossman MH, Hare TA, Manyam NVB (1979) Measurement of γ-aminobutyric acid in human whole blood and amniotic fluid. Fed Proc 38: 375Google Scholar
  35. 35.
    Haber B, Kuriyama K, Roberts E (1970) An anion stimulated L-glutamic acid decarboxylase in non-neuronal tissues. Biochem Pharmacol 19: 1119–1136CrossRefGoogle Scholar
  36. 36.
    Harrison NL, Majewska MD, Harrington JW, Barker JL (1987) Structure-activity relationships for Steroid interaction with the GABAA receptor complex. J Pharmacol Exp. Ther 241: 346–353PubMedGoogle Scholar
  37. 37.
    Hill DR, Bowery NG (1981) [3H] GABA bind to bicuculline-insensitive GABAB sites in rat brain. Nature 290: 149–152PubMedCrossRefGoogle Scholar
  38. 38.
    Kannisto P, Owan Ch, SchmidtG, WallesB(1986) Evidence for prejunctional GABABreceptors mediating inhibition of ovarian follicle contraction induced by nerve Stimulation. Eur J Pharmacol 122: 123–129PubMedCrossRefGoogle Scholar
  39. 39.
    László A, Nádasy GL, Monos E, Zsolnai B (1988) Effect of pharmacological agents on the activity of the circular and longitudinal smooth muscle layers of human Fallopian tube ampullar segments. Act Physiol Hung 72: 123–133Google Scholar
  40. 40.
    Lázló Á, Villänyi P, Zsolnai B, Erdö SL (1989) Gamma-aminobutyric acid, its related enzymes and reeeptor-binding sites in the human ovary and fallopian tube. Gynecol Obstet Invest 28: 94–97CrossRefGoogle Scholar
  41. 41.
    Lásló Á, Nádasy GL, Erdö SL, Monos E, Siklösi Gy, Zsolnai B (1990) Effect of GABA on the spontaneous muscular activity of the human Fallopian tube ampullar segments in vitro. Acta Physiol Hung (to be published)Google Scholar
  42. 42.
    Louzan P, Gallardo MG, Tramezzani JH (1986) Gamma-aminobutyric acid in the genital tract of the rat during the oestrous cycle. J Reprod Fertil 77: 499–504PubMedCrossRefGoogle Scholar
  43. 43.
    Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM (1986) Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232: 1004–1007PubMedCrossRefGoogle Scholar
  44. 44.
    Majewska MD (1987) Antagonist-type interaction of glucocorticoids with the GABA receptor-coupled chloride Channel. Brain Res 418: 377–382PubMedCrossRefGoogle Scholar
  45. 45.
    Majewska MD, Schwartz RD (1987) Pregnenolone-sulfate: an endogenous antagonist of the y-aminobutyric acid receptor complex in brain. Brain Res 404: 355–360PubMedCrossRefGoogle Scholar
  46. 46.
    Martin del Rio R (1981) γ-Aminobutyric acid system in rat oviduct. J Biol Chem 256: 9816–9819PubMedGoogle Scholar
  47. 47.
    Martin del Rio R, Latorre Caballero A (1980) Presence of y - a minobutyric acid in rat ovary. J Neurochem 34: 1584–1586PubMedCrossRefGoogle Scholar
  48. 48.
    Martin del Rio R, Sierra Lopez M (1983) Effects of aminooxyacetic acid on in vivo y-aminobutyric system of rat oviduct. Gen Pharmacol 14: 281–283CrossRefGoogle Scholar
  49. 49.
    Murashima YL, Kato T (1986) Distribution of gamma-aminobutyric acid and glutamate decarboxylase in the layers of rat oviduct. J Neurochem 46: 166–172PubMedCrossRefGoogle Scholar
  50. 50.
    Nádasy GL, László Á, Monos E, Zsolnai B (1988) Spontaneous periodic contraction of the ampullar segment of the human Fallopian tube in vitro. Acta Physiol Hung 72: 13–21PubMedGoogle Scholar
  51. 51.
    Nicoll RA (1988) The coupling of neurotransmitter receptors to ion Channels in the brain. Science 241: 545–551PubMedCrossRefGoogle Scholar
  52. 52.
    Okada Y, Taniguchi H, Baba S (1982) High concentration of GABA in pancreatic islets with special emphasis on B cells. In: Okada Y, Roberts E (eds) Problems in GABA research from brain to bacteria. Excerpta Medica, Amsterdam, pp 379-386Google Scholar
  53. 53.
    Olsen RW, Greenlee D, Van Ness P, Ticku MK (1978) Stüdes on gammaaminobutyric acid receptor/ionophore proteins in mammalian brain. In: Fonnum F. (ed) Amino acids as chemical transmitters. Plenum, New York, pp 467–486Google Scholar
  54. 54.
    Olsen RW, Bergman MO, Van Ness PC, Lummis SC, Wathins AE, Napias C, Greenlee D (1981) y-aminobutyric acid receptor binding in mammalian brain: heterogeneity of binding sites. Mol Pharmacol 19: 217–227PubMedGoogle Scholar
  55. 55.
    Orensanz LM, Azuara C, Fernändez I (1985) Lack of efect of GABA on [3H]leucine incorporation into a rat oviduct ribosomal system. Neurochem Res 10: 789–796PubMedCrossRefGoogle Scholar
  56. 56.
    Orensanz LM, Fernändez I, Martin del Rio R, Storm-Mathisen J (1986) Gammaaminobutyric acid system in the rat oviduct. Adv Biochem Psychopharmacol 42: 265–274PubMedGoogle Scholar
  57. 57.
    Riesz M, Erdö SL (1985) GABAB receptors in the rabbit uterus may medicate contractile responses. Eur J Pharmacol 119: 199–204PubMedCrossRefGoogle Scholar
  58. 58.
    Roberts E, Chase TN, Tower DB (1976) GABA in nervous system funetion. Raven, New YorkGoogle Scholar
  59. 59.
    Schaeffer JM, Hsueh AJW (1982) Identification of gamma-aminobutyric acid and its binding sites in the rat ovary. Life Sei 30: 1599–1604CrossRefGoogle Scholar
  60. 60.
    Tanaka C (1985) y-aminobutyric acid in peripheral tissue. Life Sei 37: 2221–2235CrossRefGoogle Scholar
  61. 61.
    Turner AJ, Whittle SR (1983) Biochemical dissection of the gamma-aminobutyrate synapse. Biochem J 209: 29–41PubMedGoogle Scholar
  62. 62.
    Vincent SR, Kimura H, McGeer EG (1980) The pharmacohistochernical demonstration of GABA-transaminase. Neurosci Lett 16: 354–348CrossRefGoogle Scholar
  63. 63.
    Wolf R, Meier-Fleitmann A, Düker EM, Wuttke W (1986) Intraovarian secretion of catecholamines, Oxytocin, beta-endorphin, and gamma-aminobutyric acid in freely moving rats: development of a push-pull tubing method. Biol Reprod 35: 599–607PubMedCrossRefGoogle Scholar
  64. 64.
    Wu JY (1982) Characterization of L-gl utamate decarboxylase in neural and non-neural tissues. In: Okada Y, Roberts E (eds) Problems in GABA research from brain to bacteria. Excerpta Medica, Amsterdam, pp 40-54Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Á. László
  • G. L. Nádasy
  • E. Monos
  • B. Zsolnai
  • S. L. Erdö

There are no affiliations available

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