GABA and the Liver: The First 40 Years

  • G. Y. Minuk

Abstract

Despite the fact that it has been approximately 40 years since high concentrations of GABA were first described in the liver, relatively little is known about the role GABA plays in hepatobiliary function and disease. Indeed, much of the effort over the past 40 years has consisted of documenting hepatic GABA concentrations in various animal species and quantitating the amount of enzymes responsible for GABA synthesis and metabolism. Only in the past 10 years has a concerted effort been made to determine the functional importance of GABA in the liver. The preliminary results of this more recent work suggest that GABAergic innervation of the liver not only exists, but may play an important role in regulating hepatic development and function. The purpose of this review will be to discuss the results of the past decade of research regarding GABA in the liver and, in the process, identify specific directions that future research might take.

Keywords

Hepatitis Diazepam Acetyl Neuroblastoma Thymidine 

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© Springer-Verlag Berlin Heidelberg 1992

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  • G. Y. Minuk

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