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Blood-Brain Glucose Transfer

  • Chapter
Book cover Physiology and Pharmacology of the Blood-Brain Barrier

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 103))

Abstract

Under normal circumstances, a mixture of α-and β-D-glucopyranose (D-glucose) is the only fuel of brain energy metabolism (Pardridge 1983). The breakdown of D-glucose is regulated by complex mechanisms that influence the activities of phosphofructokinase and hexokinase. The metabolism depends indirectly on the glucose concentration of the brain intracellular and interstitial fluids. Since the tissue glucose concentration, in turn, depends directly on the glucose phosphorylation rate, the blood-brain transfer assumes a pivotal role in the supply of glucose to the brain.

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  1. Physiology Group Biomedical Sciences Division King’s College London, University of London, Strand, WC2R 2LS, London, Great Britain

    Michael W. B. Bradbury M.A., D.M. (Oxon)

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Gjedde, A. (1992). Blood-Brain Glucose Transfer. In: Bradbury, M.W.B. (eds) Physiology and Pharmacology of the Blood-Brain Barrier. Handbook of Experimental Pharmacology, vol 103. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76894-1_4

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