Experimental Manipulation of the Blood-Brain ”and Blood-Retinal Barriers

  • J. Greenwood
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 103)

Abstract

There exists two major areas of research in which experimental manipulation of the blood-brain barrier (BBB) and blood-retinal barrier (BRB) are routinely employed. Firstly, there are a broad range of investigations undertaken to elucidate the various cellular mechanisms involved in precipitating both the structural and fuctional alterations of the barrier often found in diseases of the central nervous system (CNS). Secondly, there are those studies involved in the discovery and characterisation of agents capable of disrupting the integrity of the BBB and BRB with the ultimate aim of developing a safe method for enhancing the delivery of therapeutic agents to the CNS.

Keywords

Serotonin Luminal Meningitis Thrombin Indomethacin 

Abbreviations

ADP

Adenosine diphosphate

AMP

Adenosine monophosphate

ATP

Adenosine triphosphate

BBB

Blood-brain barrier

BRB

Blood-retinal barrier

cAMP

Cyclic AMP

CNS

Central nervous system

DMSO

Dimethyl sulphoxide

HRP

Horseradish peroxidase

5-HT

5-hydroxytryptamine

IL

Interleukin

LAK

Lymphokine-activated killer

MIP

Macrophage inflammatory protein

PAF

Platelet activating factor

TCDC

Taurochenodeoxycholate

TNF

Tumour necrosis factor

VPF

Vascular permeability factor

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References

  1. Alexander JT, Saris SC, Oldfield EH (1989) The effect of interleukin-2 on the blood-brain barrier in the 9L gliosarcoma rat model. J Neurosurg 70:92–96PubMedGoogle Scholar
  2. Ashton N, Cunha-Vaz JG (1965) Effect of histamine on the permeability of the ocular vessels. Arch Ophthalmol 73:211–223PubMedGoogle Scholar
  3. Baethmann A, Maier-Hauff K, Kempski O, Unterberg A, Wahl M, Schurer L (1988) Mediators of brain edema and secondary brain damage. Crit Care Med 16:972–978PubMedGoogle Scholar
  4. Balin BJ, Broadwell RD, Salcman M (1987) Tubular profiles do not form transendothelial channels through the blood-brain barrier. J Neurocytol 16: 721–735PubMedGoogle Scholar
  5. Black KL (1984) Leukotriene C4 induces vasogenic cerebral edema in rats. Prostaglandins Leukotrienes Med 14:339–340Google Scholar
  6. Black KL, Hoff JT (1985) Leukotrienes increase blood-brain barrier permeability following intraparenchymal injections in rats. Ann Neurol 18:349–351PubMedGoogle Scholar
  7. Bleakman D, Naftalin RJ (1990) Hypertonic fluid absorption from rabbit descending colon in vitro. Am J Physiol 258:G377-G390PubMedGoogle Scholar
  8. Bolwig TG (1989) Epileptic seizures and the blood-brain barrier. In: Neuwelt EA (ed) Implications of the blood-brain barrier and its manipulations, vol 2. Plenum, New York, pp 567–574Google Scholar
  9. Brightman MW, Hon M, Rapoport SI, Reese TS, Westergaard E (1973) Osmotic opening of tight junctions in cerebral endothelium. J Comp Neurol 152:317–326PubMedGoogle Scholar
  10. Brinker RA (1979) Neuroangiographic contrast agents. In: Miller RE, Skucas J (eds) Radiographic contrast agents. University Park Press, Baltimore, pp 365–374Google Scholar
  11. Broadwell RD, Salcman M, Kaplan SR (1982) Morphological effect of dimethyl sulfoxide on the blood-brain barrier. Science 217:164–166PubMedGoogle Scholar
  12. Brosnan CF, Claudio L, Tansey FA, Martiney J (1990) Mechanisms of autoimmune neuropathies. Ann Neurol [Suppl] 27:S75-S79Google Scholar
  13. Bruce JN, Criscuolo GR, Merrill MJ, Moquin RR, Blacklock JB, Oldfield EH (1987) Vascular permeability induced by protein product of malignant brain tumors. J Neurosurg 67:880–884PubMedGoogle Scholar
  14. Chan PH, Longar S, Fishman RA (1987) Protective effects of liposome-entrapped superoxide dismutase on posttraumatic brain edema. Ann Neurol 21:540–547PubMedGoogle Scholar
  15. Cosolo WC, Martinello P, Louis WS, Christophidis N (1989) Blood-brain barrier disruption using mannitol: time course and electron microscopy studies. Am J Physiol 256:R443-R447PubMedGoogle Scholar
  16. Criscuolo GR, Merrill MJ, Oldfield EH (1988) Further characterization of malignant glioma-derived vascular permeability factor. J Neurosurg 69:254–262PubMedGoogle Scholar
  17. Criscuolo GR, Lelkes PI, Rotrosen D, Oldfield EH (1989) Cytosolic calcium changes in endothelial cells induced by a protein product of human gliomas containing vascular permeability factor activity. J Neurosurg 71:884–891PubMedGoogle Scholar
  18. Cserr HF, Dasquale M, Patlak CS (1987) Volume regulatory influx of electrolytes from plasma to brain during acute hyperosmolarity. Am J Physiol 253: F530-F537PubMedGoogle Scholar
  19. Dietrich WD, Prado R, Watson BD, Nakayama H (1988a) Middle cerebral artery thrombosis: acute blood-brain barrier consequences. J Neuropathol Exp Neurol 47:443–451PubMedGoogle Scholar
  20. Dietrich WD, Prado R, Watson BD (1988b) Photochemically stimulated blood- borne factors induce blood-brain barrier alterations in rats. Stroke 19:857–862PubMedGoogle Scholar
  21. Domer FR, Boertje SB, Bing EG, Reddix I (1983) Histamine- and acetylcholine- induced changes in the permeability of the blood-brain barrier of normotensive and spontaneously hypertensive rats. Neuropharmacology 22:615–619PubMedGoogle Scholar
  22. Dull R, Vergis GJ, Hollis TM (1986) Effect of chronic histamine infusion on the permeability of the blood-retinal barrier. Fed Proc 45:462Google Scholar
  23. Dux E, Joó F (1982) Effects of histamine on brain capillaries. Fine structural and immunohistochemical studies after intracarotid infusion. Exp Brain Res 47: 252–258PubMedGoogle Scholar
  24. Ellison MD, Povlishock JT, Merchant RE (1987) Blood-brain barrier in cats following recombinant interleukin-2 infusion. Cancer Res 47:5765–5770PubMedGoogle Scholar
  25. Ellison MD, Krieg RJ, Povlishock JT (1990) Differential central nervous system responses following single and multiple recombinant interleukin-2 infusions. J Neuroimmunol 28:249–260PubMedGoogle Scholar
  26. Enea NA, Hollis TM, Kern JA, Gardner TW (1989) Histamine H1 receptors mediate increased blood-retinal barrier permeability in experimental diabetes. Arch Ophthalmol 107:270–274PubMedGoogle Scholar
  27. Ennis SR, Betz AL (1986) Sucrose permeability of the blood-retinal and blood-brain barriers. Effects of diabetes, hypertonicity, and iodate. Invest Ophthalmol Vis Sci 27:1095–1102PubMedGoogle Scholar
  28. Essner E (1987) Role of vesicular transport in breakdown of the blood-retinal barrier. Lab Invest 56:457–460PubMedGoogle Scholar
  29. Farrell CL, Shivers RR (1984) Capillary junctions of the rat are not affected by osmotic opening of the blood-brain barrier. Acta Neuropathol (Berl) 63: 179–189Google Scholar
  30. Fieschi C, Lenzi GL, Zanette E, Orzi F, Passero S (1980) Effects on EEG of the osmotic opening of the blood-brain barrier in rats. Life Sci 27:239–243PubMedGoogle Scholar
  31. Frank JA, Dwyer AJ, Girton M, Knop RH, Sank VJ, Gansow OA, Magerstadt M, Brechbiel M, Doppman JL (1986) Opening of blood-ocular barrier demonstrated by contrast-enhanced MR imaging. J Comput Assist Tomogr 10:912–916PubMedGoogle Scholar
  32. Fraser PA, Dallas AD (1990) Measurement of filtration coefficient in single cerebral microvessels of the frog. J Physiol (Lond) 423:343–361Google Scholar
  33. Frerichs KU, Lindsberg PJ, Hallenbeck JM, Feuerstein GZ (1990) Platelet-activating factor and progressive brain damage following focal brain injury. J Neurosurg 73:223–233PubMedGoogle Scholar
  34. Gabbiani G, Badonnel MC, Majno G (1970) Intra-arterial injections of histamine, serotonin, or bradykinin: a topographic study of vascular leakage. Proc Soc Exp Biol Med 135:447–452PubMedGoogle Scholar
  35. Godeau G, Gavignet C, Groult N, Robert AM (1987) Effect of chromocarb diethylamine on the permeability of the blood-brain barrier. Clin Physiol Biochem 5:15–26PubMedGoogle Scholar
  36. Greenwood J (1991a) Mechanisms of blood-brain barrier breakdown. Neuroradiology 33:95–100PubMedGoogle Scholar
  37. Greenwood J (1991b) Astrocytes, cerebral endothelium and cell culture: the pursuit of an in vitro blood-brain barrier. Ann NY Acad Sci 633:426–431PubMedGoogle Scholar
  38. Greenwood J, Luthert PJ, Pratt OE, Lantos PL (1985) Maintenance of the integrity of the blood-brain barrier in the rat during an in situ saline-based perfusion. Neurosci Lett 56:223–227PubMedGoogle Scholar
  39. Greenwood J, Luthert PJ, Pratt OE, Lantos PL (1988) Hyperosmolar opening of the blood-brain barrier in the energy-depleted rat brain. I. Permeability studies. J Cereb Blood Flow Metab 8:9–15PubMedGoogle Scholar
  40. Greenwood J, Hazell AS, Luthert PJ (1989) The effect of a low saline perfusate upon the integrity of energy-depleted rat blood-brain barrier. J Cereb Blood Flow Metab 9:234–242PubMedGoogle Scholar
  41. Greenwood J, Adu J, Davey AJ, Abbott NJ, Bradbury MWB (1991) The effect of bile salts upon the permeability and ultrastructure of the perfused, energy- depleted, rat blood-brain barrier. J Cereb Blood Flow Metab 11:644–654PubMedGoogle Scholar
  42. Greig N, Hellmann K (1983) Enhanced cerebrovascular permeability by metrazol: significance for brain metastases. Clin Exp Metastasis 1:83–95PubMedGoogle Scholar
  43. Greig N, Newell D, Hellmann K (1984) Metrazol enhances brain penetration and therapeutic efficacy of some anticancer agents: implications for brain metastases. Clin Exp Metastasis 2:55–59PubMedGoogle Scholar
  44. Greig NH (1989) Drug delivery to the brain by blood-brain barrier circumvention and drug modification. In: Neuwelt EA (ed) Implications of the blood-brain barrier and its manipulations, vol 1. Plenum, New York, pp 311–367Google Scholar
  45. Greig NH, Sweeney DJ, Rapoport SI (1985) Inability of dimethyl sulfoxide to increase brain uptake of water-soluble compounds: implications to chemotherapy for brain tumors. Cancer Treat Rep 69:305–312PubMedGoogle Scholar
  46. Gross PM, Teasdale GM, Angerson WJ, Harper AM (1981) H2-receptors mediate increases in permeability of the blood-brain barrier during arterial histamine infusion. Brain Res 210:396–400.PubMedGoogle Scholar
  47. Gross PM, Teasdale GM, Graham DI, Angerson WJ, Harper AM (1982) Intraarterial histamine increases blood-brain transport in rats. Am J Physiol 243:H307-H317PubMedGoogle Scholar
  48. Gulati A, Agarwal SK, Shukla R, Srimal RC, Dhawan BN (1985a) The mechanism of opening of the blood-brain barrier by hypertonic saline. Neuropharmacology 24:909–913PubMedGoogle Scholar
  49. Gulati A, Dhawan KN, Shukla R, Srimal RC, Dhawan BN (1985b) Evidence for the involvment of histamine in the regulation of blood-brain barrier permeability. Pharmacol Res Commun 17:395–404PubMedGoogle Scholar
  50. Gumerlock MK, Neuwelt EA (1990) The effects of anesthesia on osmotic blood- brain barrier disruption. Neurosurgery 26:268–277PubMedGoogle Scholar
  51. Hambrecht GS, Adesuyi SA, Holt S, Ellis EF (1987) Brain 12-HETE formation in different species, brain regions, and in brain micro vessels. Neurochem Res 12:1029–1033PubMedGoogle Scholar
  52. Hansson HA, Johansson BB (1980) Induction of pinocytosis in cerebral vessels by acute hypertension and by hyperosmolar solutions. J Neurosci Res 5:183–190PubMedGoogle Scholar
  53. Hardebo JE (1980) A time study in rat on the opening and reclosure of the blood-brain barrier after hypertensive or hypertonic insult. Exp Neurol 70: 155–166PubMedGoogle Scholar
  54. Hardebo JE, Kahrstrom J (1985) Endothelial negative surface charge areas and blood-brain barrier function. Acta Physiol Scand 125:495–499PubMedGoogle Scholar
  55. Hardebo JE, Nilsson B (1980) Hemodynamic changes in brain caused by local infusion of hyperosmolar solutions, in particular relation to blood-brain barrier opening. Brain Res 181:49–59PubMedGoogle Scholar
  56. Hardebo JE, Owman C, Wiklund L (1981) Influence of neurotransmitter monoamines and neurotoxic analogues on morphologic blood-brain barrier function. In: Cervos-Navarro J, Fritschka E (eds) Cerebral microcirculation and metabolism. Raven, New York, pp 177–180Google Scholar
  57. Hollerhage H-G, Walter GF, Stolke D (1989) Complement-derived polypeptide C3aderg as a mediator of inflammation at the blood-brain barrier in a new experimental cat model. Acta Neuropathol (Berl) 77:307–313Google Scholar
  58. Hollis TM, Gardner TW, Vergis GJ, Kirbo BJ, Butler C, Dull RO, Campos MJ, Enea NA (1988) Antihistamines reverse blood-ocular barrier breakdown in experimental diabetes. J Diabetic Complications 2:47–49Google Scholar
  59. Houthoff HJ, Go KG, Gerrits PO (1982) The mechanism of blood-brain barrier impairment by hyperosmolar perfusion. Acta Neuropathol (Berl) 56:99–112Google Scholar
  60. Johansson BB (1989) Hypertension and the blood-brain barrier. In: Neuwelt EA (ed) Implications of the blood-brain barrier and its manipulations, vol 2. Plenum, New York, pp 389–410Google Scholar
  61. Joó F (1987) A unifying concept on the pathogenesis of brain oedemas. Neuropathol Appl Neurobiol 13:161–176PubMedGoogle Scholar
  62. Joó F, Temesvari P, Dux E (1983) Regulation of the macromoleeular transport in the brain microvessels: the role of cyclic GMP. Brain Res 278:165–174PubMedGoogle Scholar
  63. Kempski O, Villacara A, Spatz M, Dodson RF, Corn C, Merkel N, Bembry J (1987) Cerebromicrovascular endothelial permeability. In vitro studies. Acta Neuropathol (Berl) 74:329–334Google Scholar
  64. Kilzer P, Chang K, Marvel J, Kilo C, Williamson JR (1985) Tissue differences in vascular permeability changes induced by histamine. Micro vase Res 30:270–285Google Scholar
  65. Koenig H, Goldstone AD, Lu CY (1989a) Polyamines mediate the reversible opening of the blood-brain barrier by the intracarotid infusion of hyperosmolal mannitol. Brain Res 483:110–116PubMedGoogle Scholar
  66. Koenig H, Goldstone AD, Lu CY, Trout JJ (1989b) Polyamines and Ca2+ mediate opening of the blood-brain barrier: in vitro studies in isolated rat cerebral capillaries. J Neurochem 52:1135–1142PubMedGoogle Scholar
  67. Kontos HA (1985) Oxygen radicals in cerebral vascular injury. Circ Res 57:508–516PubMedGoogle Scholar
  68. Kontos HA, Wei EP, Povlishock JT, Dietrich WD, Magiera CJ, Ellis EF (1980) Cerebral arteriolar damage by arachidonic acid and prostaglandin G2. Science 209:1242–1245PubMedGoogle Scholar
  69. Kumar R, Harvey SAK, Kester M, Hanahan DJ, Olson MS (1988) Production and effects of platelet-activating factor in the rat brain. Biochim Biophys Acta 963:375–383PubMedGoogle Scholar
  70. Lantos G (1989) Cortical blindness due to osmotic disruption of the blood-brain barrier by angiographic contrast material: CT and MRI studies. Neurology 39:567–571PubMedGoogle Scholar
  71. Lee JC, Olszewski J (1961) Increased cerebrovascular permeability after repeated electroshocks. Neurology (Minneap) 11:515–519Google Scholar
  72. Lehtosalo J, Panula P, Laitinen LA (1982) The permeability alteration of brain and spinal cord vasculature to horseradish peroxidase during experimental decompression sickness as compaired to the alteration in permeability induced by hyperosmolar solution. Acta Neuropathol (Berl) 57:179–187Google Scholar
  73. Li V, Turski PA, Levin AB, Weinstein J, Rozental J, Strother CM (1987) Osmotic disruption of the blood-ocular barriers. AJNR 8:347–348PubMedGoogle Scholar
  74. Liaw CW, Cannon C, Power MD, Kiboneka PK, Rubin LL (1990) Identification and cloning of two species of Cadherins in bovine endothelial cells. EMBO J 9: 2701–2708PubMedGoogle Scholar
  75. Lightman S, Rechthand E, Latker C, Palestine A, Rapoport S (1987) Assessment of the permeability of the blood-retinal barrier in hypertensive rats. Hypertension 10:390–395PubMedGoogle Scholar
  76. Lin WL (1988) Leakage of blood-retinal barrier due to damaging effect of protamine sulfate on the endothelium. Acta Neuropathol (Berl) 76:427–431Google Scholar
  77. Lorenzo AV, Shirahige I, Liang M, Barlow CF (1972) Temporary alteration of cerebrovascular permeability to plasma proteins during drug-induced seizures. Am J Physiol 223:268–277PubMedGoogle Scholar
  78. Lorenzo AV, Hedley-Whyte ET, Eisenberg HM, Hso DW (1975) Increased penetration of horseradish peroxidase across the blood-brain barrier induced by metrazol seizures. Brain Res 88:136–140PubMedGoogle Scholar
  79. Luthert PJ, Greenwood J (1989) Experimental studies and the blood-brain barrier. In: Capildeo R (ed) Steroids in diseases of the central nervous system. Wiley, New York, pp 47–57Google Scholar
  80. Luthert PJ, Greenwood J, Lantos PL, Pratt OE (1986) The effects of dexamethasone on vascular permeability of experimental brain tumours. Acta Neuropathol (Berl) 69:288–294Google Scholar
  81. Luthert PJ, Greenwood J, Pratt OE, Lantos PL (1987) The effect of a metabolic inhibitor upon the properties of the cerebral vasculature during a whole-head saline perfusion of the rat. Q J Exp Physiol 72:129–141PubMedGoogle Scholar
  82. Martins AN, Doyle TF, Wright SJ, Bass B (1980) Response of cerebral circulation to topical histamine. Stroke 11:469–476PubMedGoogle Scholar
  83. Mayhan WG, Heistad DD (1985) Permeability of blood-brain barrier to various sized molecules. Am J Physiol 248:H712-H718PubMedGoogle Scholar
  84. Mayhan WG, Sahagun G, Spector R, Heistad DD (1986) Effects of leukotriene C4 on the cerebral microvasculature. Am J Physiol 251:H471-H474PubMedGoogle Scholar
  85. Mayhan WG, Faraci FM, Siems JL, Heistad DD (1989) Role of molecular charge in disruption of the blood-brain barrier during acute hypertension. Circ Res 64:658–664PubMedGoogle Scholar
  86. Moore SA, Prokuski LJ, Figard PH, Spector AA, Hart MN (1988) Murine cerebral microvascular endothelium incorporate and metabolize 12- hydroxyeicosatetraenoic acid. J Cell Physiol 137:75–85PubMedGoogle Scholar
  87. Moore SA, Figard PH, Spector AA, Hart MN (1989) Brain microvessels produce 12-hydroxyeicosatetraenoic acid. J Neurochem 53:376–382PubMedGoogle Scholar
  88. Murphy VA, Johanson CE (1985) Adrenergic-induced enhancement of brain barrier system permeability to small non-electrolytes: choroid plexus versus cerebral capillaries. J Cereb Blood Flow Metab 5:401–412PubMedGoogle Scholar
  89. Nag S (1984) Cerebral endothelial surface charge in hypertension. Acta Neuropathol (Berl) 63:276–281Google Scholar
  90. Nagy Z, Pappius HM, Mathieson G, Huttner I (1979) Opening of tight junctions in cerebral endothelium. I. Effect of hyperosmolar mannitol infused through the internal carotid artery. J Comp Neurol 185:569–578PubMedGoogle Scholar
  91. Nagy Z, Peters H, Huttner I (1981) Endothelial surface charge: blood-brain barrier opening to horseradish peroxidase induced by the polycation protamine sulfate. Acta Neuropathol (Berl) 7[Suppl]:7–9Google Scholar
  92. Nagy Z, Peters H, Huttner I (1983) Charge-related alterations of the cerebral endothelium. Lab Invest 49:662–671PubMedGoogle Scholar
  93. Nagy Z, Szabo M, Huttner I (1985) Blood-brain barrier impairment by low buffer perfusion via the internal carotid artery in the rat. Acta Neuropathol (Berl) 68:160–163Google Scholar
  94. Nakagawa H, Groothuis D, Blasberg RG (1984) The effect of graded hypertonic intracarotid infusions in drug delivery to experimental RG-2 gliomas. Neurology (NY) 32:1571–1581Google Scholar
  95. Naveh N, Weissman C (1990) The correlation between excessive vitreal protein levels, prostaglandin E2 levels, and the blood-retinal barrier. Prostaglandins 39:147–156PubMedGoogle Scholar
  96. Neuwelt EA, Barnett PA (1989) Blood-brain barrier disruption in the treatment of brain tumours: animal studies. In: Neuwelt E A (ed) Implications of the blood- brain barrier and its manipulations, vol 2. Plenum, New York, pp 107–194Google Scholar
  97. Neuwelt EA, Barnett P, Barranger J, Mormick C, Pagel M, Frenkel E (1983) Inability of dimethyl sulfoxide and 5-fluorouracil to open the blood-brain barrier. Neurosurgery 12:29–34PubMedGoogle Scholar
  98. Neuwelt EA, Horaczek A, Pagel MA (1990) The effect of steroids on gentamicin delivery to brain after blood-brain barrier disruption. J Neurosurg 72:123–126PubMedGoogle Scholar
  99. Ohnishi T, Sher PB, Posner JB, Shapiro WR (1990) Capillary permeability factor secreted by malignant brain tumor. J Neurosurg 72:245–251PubMedGoogle Scholar
  100. Olesen SP (1985) A calcium-dependent reversible increase in micro vessels in frog brain induced by serotonin. J Physiol (Lond) 361:103–113Google Scholar
  101. Olesen SP (1987a) Leakeness of rat brain microvessels to fluorescent probes following craniotomy. Acta Physiol Scand 130:63–68PubMedGoogle Scholar
  102. Olesen SP- (1987b) Free oxygen radicals decrease electrical resistance of microvascular endothelium in brain. Acta Physiol Scand 129:181–188PubMedGoogle Scholar
  103. Olesen SP (1987c) Regulation of ion permeability in frog brain venules. Significance of calcium, cyclic nucleotides and protein kinase C. J Physiol (Lond) 387:59–68Google Scholar
  104. Olesen SP, Crone C (1986) Substances that rapidly augment ionic conductance of endothelium in cerebral venules. Acta Physiol Scand 127:233–241PubMedGoogle Scholar
  105. Papadopoulos SM, Black KL, Hoff JT (1989) Cerebral edema induced by arachidonic acid: role of leukocytes and 5-lipoxygenae products. Neurosurgery 25:369–372PubMedGoogle Scholar
  106. Pardridge WM, Kumagai AK, Eisenberg JB (1987) Chimeric peptides as a vehicle for peptide pharmaceutical delivery through the blood-brain barrier. Biochem Biophys Res Commun 146:307–313PubMedGoogle Scholar
  107. Pickard JD, Durity F, Welsh FA, Langfitt TA, Harper AM, Maenzie ET (1977) Osmotic opening of the blood-brain barrier: value in pharmacological studies on the cerebral circulation. Brain Res 122:170–176PubMedGoogle Scholar
  108. Pino RM (1987) Perturbation of the blood-retinal barrier after enzyme perfusion. A cytochemical study. Lab Invest 56:475–480PubMedGoogle Scholar
  109. Pober JS, Cotran RS (1990) Cytokines and endothelial cell biology. Physiol Rev 70:427–451PubMedGoogle Scholar
  110. Rakic LM, Zlokovic BV, Davson H, Segal MB, Begley DJ, Lipovac MN, Mitrovic UM (1989) Chronic amphetamine intoxication and the blood-brain barrier permeability to inert polar molecules in the vascularly perfused guinea pig brain. J Neurol Sci 94:41–50PubMedGoogle Scholar
  111. Rapoport SI (1977) Osmotic opening of blood-brain and blood-ocular barriers. Exp Eye Res 25[Suppl]:499–509PubMedGoogle Scholar
  112. Rapoport SI, Robinson PJ (1986) Tight-junctional modification as the basis of osmotic opening of the blood-brain barrier. Ann NY Acad Sci 481:250–266PubMedGoogle Scholar
  113. Rapoport SI, Matthews K, Thompson HK, Pettigrew KD (1977) Osmotic opening of the blood-brain barrier in the rhesus monkey without measurable brain edema. Brain Res 136:23–29PubMedGoogle Scholar
  114. Rapoport SI, Fredericks WR, Ohno K, Pettigrew KD (1980) Quantitative aspects of reversible omo tic opening of the blood-brain barrier. Am J Physiol 238: R421-R431PubMedGoogle Scholar
  115. Raymond JJ, Robertson DM, Dinsdale HB (1986) Pharmacological modification of bradykinin induced breakdown of the blood-brain barrier. Can J Neurol Sci 13:214–220PubMedGoogle Scholar
  116. Robert AM, Godeau G, Miskulin M, Moati F (1977) Mechanism of action of collagenase on the permeability of the blood-brain barrier. Neurochem Res 2:449–455Google Scholar
  117. Robinson PJ (1987) Facilitation of drug entry into brain by osmotic opening of the blood-brain barrier. Clin Exp Pharmacol Physiol 14:887–901PubMedGoogle Scholar
  118. Robinson PJ, Rapoport SI (1987) Size selectivity of blood-brain barrier permeability at various times after osmotic opening. Am J Physiol 253:R459-R466PubMedGoogle Scholar
  119. Rubin LL, Barbu K, Bard F, Cannon C, Hall DE, Horner H, Janatpour M, Liaw C, Manning K, Morales J, Porter S, Tanner L, Tomaselli K, Yednock T (1991) Differentiation of brain endothelial cells in cell culture. Ann NY Acad Sci 633: 420–425PubMedGoogle Scholar
  120. Sahagun G, Moore SA, Hart MN (1990) Permeability of neutral vs. anionic dextrans in cultured brain microvascular endothelium. Am J Physiol 259:H162-H166PubMedGoogle Scholar
  121. Saija A, Princi P, de Pasquale R, Costa G (1989) Modifications of the permeability of the blood-brain barrier and local cerebral metabolism in pentobarbital- and ketamine-anaesthetized rats. Neuropharmocology 28:997–1002Google Scholar
  122. Saria A, Lundberg JM, Skofitsch G, Lembeck F (1983) Vascular protein leakage in various tissues induced by substance P, capsaicin, bradykinin, serotonin, histamine and by antigen challenge. Naunyn Schmiedebergs Arch Pharmacol 324:212–218PubMedGoogle Scholar
  123. Sarmento A, Albino-Teixeira A, Azevedo I (1990) Amitriptyline-induced morphological alterations of the rat blood-brain barrier. Eur J Pharmacol 176:69–74PubMedGoogle Scholar
  124. Saukkonen K, Sande S, Cioffe C, Wolpe S, Sherry B, Cerami A, Tuomanen E (1990) The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis. J Exp Med 171:439–448PubMedGoogle Scholar
  125. Schurer L, Temesvari P, Wahl M, Unterberg A, Baethmann A (1989) Blood-brain barrier permeability and vascular reactivity to bradykinin after pretreatment with dexamethasone. Acta Neuropathol (Berl) 77:576–581Google Scholar
  126. Sen HA, Campochiaro PA (1989) Intra vitreous injection of adenosine or its antagonists causes breakdown of the blood-retinal barrier. Arch Ophthalmol 107:1364–1367PubMedGoogle Scholar
  127. Shakib M, Cunha-Vaz JG (1966) Studies on the permeability of the blood-retinal barrier permeability. IV. Junctional complexes of the retinal vessels and their role in the permeability of the blood-retinal barrier. Exp Eye Res 5:229–234PubMedGoogle Scholar
  128. Sharma HS, Olsson Y, Dey PK (1990) Changes in blood-brain barrier and cerebral blood flow following elevation of circulating serotonin level in anesthetized rats. Brain Res 517:215–223PubMedGoogle Scholar
  129. Sokrab TE, Kalimo H, Johansson BB (1990) Parenchymal changes related to plasma protein extravasation in experimental seizures. Epilepsia 31:1–8PubMedGoogle Scholar
  130. Spigelman MK, Zappulla R, Malis LI, Holland JF, Goldsmith SJ, Goldberg JD (1983) Intracarotid dehydrocholate infusion: a new method for prolonged reversible blood-brain barrier disruption. Neurosurgery 12:606–612PubMedGoogle Scholar
  131. Spigelman MK, Zappulla RA, Goldberg JD, Goldsmith SJ, Marotta D, Malis LI, Holland JF (1984a) Effect of intracarotid etoposide on opening the blood-brain barrier. Cancer Drug Deliv 1:207–211PubMedGoogle Scholar
  132. Spigelman MK, Zappulla RA, Johnson J, Goldsmith SJ, Malis LI, Holland JF (1984b) Etoposide induced blood-brain barrier disruption — effect of drug compared with that of solvents. J Neurosurg 61:674–678PubMedGoogle Scholar
  133. Spigelman MK, Zappulla RA, Strauchen JA, Feuer EJ, Johnson J, Goldsmith SJ, Malis LI, Holland JF (1986) Etoposide induced blood-brain barrier disruption in rats: duration of opening and histological sequelae. Cancer Res 46:1453–1457PubMedGoogle Scholar
  134. Stewart PA, Hayakawa EM, Carlen PL (1988) Ethanol and pentobarbital in combination increase blood-brain barrier permeability to horseradish peroxidase. Brain Res 443:12–20PubMedGoogle Scholar
  135. Strausbaugh LJ (1987) Intracarotid infusions of protamine sulfate disrupt the blood- brain barrier of rabbits. Brain Res 409:221–226PubMedGoogle Scholar
  136. Suzuki M, Iwasaki Y, Yamamoto T, Konno H, Kudo H (1988) Sequelae of the osmotic blood-brain barrier opening in rats. J Neurosurg 69:421–428PubMedGoogle Scholar
  137. Unterberg A, Wahl M, Baethmann A (1984) Effects of bradykinin on permeability and diameter of pial vessels in vivo. J Cereb Blood Flow Metab 4:574–585PubMedGoogle Scholar
  138. Unterberg A, Wahl M, Hammersen F, Baethmann A (1987) Permeability and vasomotor response of cerebral vessels during exposure to arachidonic acid. Acta Neuropathol (Berl) 73:209–219Google Scholar
  139. Unterberg A, Wahl M, Baethmann A (1988) Effects of free radicals on permeability and vasomotor response of cerebral vessels. Acta Neuropathol (Berl) 76:238–244Google Scholar
  140. Vorbrodt AW (1987) Demonstration of anionic sites on the luminal and abluminal fronts of endothelial cells with poly-L-lysine gold complex. J Histochem Cytochem 35:1261–1266PubMedGoogle Scholar
  141. Wahl M, Unterberg A, Baethmann A (1985) Intravital fluorescence microscopy for the study of blood-brain barrier function. Int J Microcirc Clin Exp 4:3–18Google Scholar
  142. Wahl M, Unterberg A, Baethmann A, Schilling L (1988) Mediators of blood-brain barrier dysfunction and formation of vasogenic brain edema. J Cereb Blood Flow Metab 8:621–634PubMedGoogle Scholar
  143. Waldron RL, Bryan RN (1975) Effect of contrast agents on the blood-brain barrier: an electron microscopic study. Radiology 116:195–198PubMedGoogle Scholar
  144. Watts RG, Wright JL, Atkinson LL, Merchant RE (1989) Histopathological and blood-brain barrier changes in rats induced by an intracerebral injection of human recombinant interleukin-2. Neurosurgery 25:202–208PubMedGoogle Scholar
  145. Wei EP, Ellison MD, Kontos HA, Povlishock JT (1986) 02 radicals in arachidonate- induced increased blood-brain barrier permeability to proteins. Am J Physiol 251:H693-H699PubMedGoogle Scholar
  146. Westergaard E (1977) The blood-brain barrier to horseradish peroxidase under normal and experimental conditions. Acta Neuropathol (Berl) 39:181–188Google Scholar
  147. Westergren I, Johansson BB (1990) Albumin content in brain and CSF after intracarotid infusion of protamine sulfate: a longitudinal study. Exp Neurol 107:192–196PubMedGoogle Scholar
  148. Wright DC, McCormick PC, Lawrence P, Owens E, Blasberg RG (1985) Infusions of dimethyl sulfoxide (DMSO): blood-brain barrier effects. J Cereb Blood Flow Metab 5 [Suppl l]:75–76Google Scholar
  149. Ziylan YZ, Robinson PJ, Rapoport SI (1983) Differential blood-brain barrier permeabilities to 14-C sucrose and 3-H inulin after osmotic opening in the rat. Exp Neurol 79:845–857PubMedGoogle Scholar
  150. Ziylan YZ, Robinson PJ, Rapoport SI (1984) Blood-brain barrier permeabilities to sucrose and dextran after osmotic opening. Am J Physiol 247:R634-R638PubMedGoogle Scholar
  151. Ziylan YZ, Korkmaz G, Bernard G, Lefauconnier JM (1988) Effect of dimethyl sulfoxide on blood-to-brain transfer of a-aminoisobutyric acid: examination of regional blood-brain barrier function. Neurosci Lett 89:74–79PubMedGoogle Scholar
  152. Ziylan YZ, Lefauconnier JM, Bernard G, Bourre JM (1989) Regional alterations in blood-to-brain transfer of alpha-aminoisobutyric acid and sucrose, after chronic administration and withdrawal of dexamethasone. J Neurochem 52:684–689PubMedGoogle Scholar
  153. Zuccarello M, Anderson DK (1989) Protective effect of a 21-aminosteroid on the blood-brain barrier following subarachnoid hemorrhage in rats. Stroke 20: 367–371PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • J. Greenwood

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