Experimental Manipulation of the Blood-Brain ”and Blood-Retinal Barriers

  • J. Greenwood
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 103)


There exists two major areas of research in which experimental manipulation of the blood-brain barrier (BBB) and blood-retinal barrier (BRB) are routinely employed. Firstly, there are a broad range of investigations undertaken to elucidate the various cellular mechanisms involved in precipitating both the structural and fuctional alterations of the barrier often found in diseases of the central nervous system (CNS). Secondly, there are those studies involved in the discovery and characterisation of agents capable of disrupting the integrity of the BBB and BRB with the ultimate aim of developing a safe method for enhancing the delivery of therapeutic agents to the CNS.


Tight Junction Vesicular Transport Cereb Blood Flow Barrier Disruption Cerebral Endothelium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Adenosine diphosphate


Adenosine monophosphate


Adenosine triphosphate


Blood-brain barrier


Blood-retinal barrier


Cyclic AMP


Central nervous system


Dimethyl sulphoxide


Horseradish peroxidase






Lymphokine-activated killer


Macrophage inflammatory protein


Platelet activating factor




Tumour necrosis factor


Vascular permeability factor


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© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • J. Greenwood

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