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Physiology and Pharmacology of the Blood-Brain Barrier pp 263–278Cite as

Trace Metal Transport at the Blood-Brain Barrier

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 103))

Abstract

A number of trace metals are normally present within the central nervous system (CNS), and may have effects on its function. Several, e.g., zinc, iron, copper and manganese are essential for normal brain development and function. Others, e.g., lead and mercury, have no known essential role, but may be toxic even at low concentrations. Of the essential metals, most may be toxic to the brain at high concentration, e.g., zinc, copper and manganese.

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Abbreviations

BBB:

Blood-brain barrier

CSF:

Cerebrospinal fluid

DIDS:

4,4′-diisothiocyanostilbene-2,2′-disulphonic acid

EDTA:

Ethylenediaminetetraacetic acid

HEPES:

Hydroxyethylpiperazine ethanesulphonic acid

FCCP:

Carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone

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Authors
  1. M. W. B. Bradbury
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Editors and Affiliations

  1. Physiology Group Biomedical Sciences Division King’s College London, University of London, Strand, WC2R 2LS, London, Great Britain

    Michael W. B. Bradbury M.A., D.M. (Oxon)

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© 1992 Springer-Verlag Berlin Heidelberg

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Bradbury, M.W.B. (1992). Trace Metal Transport at the Blood-Brain Barrier. In: Bradbury, M.W.B. (eds) Physiology and Pharmacology of the Blood-Brain Barrier. Handbook of Experimental Pharmacology, vol 103. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76894-1_10

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  • DOI: https://doi.org/10.1007/978-3-642-76894-1_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76896-5

  • Online ISBN: 978-3-642-76894-1

  • eBook Packages: Springer Book Archive

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