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Free Radicals and the Liver pp 63–76Cite as

Lipid Peroxidation and Associated Hepatic Organelle Dysfunction in Iron Overload

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Abstract

It has recently been recognized that genetic hemochromatosis (GH) is one of the most common inherited disorders. Approximately 0.1%–0.8% of whites of northern European ancestry are affected and the frequency of heterozygotes is thought to be about 5%–16% of the population [7, 12, 17, 20, 24, 34, 39, 43, 44, 53, 54]. In GH, there is an inappropriate increase in intestinal absorption of iron leading to progressive deposition of excess iron in parenchymal cells of the liver and several other organs [26, 28, 41, 47, 56]. The liver is the major recipient of the excess absorbed iron and after several years of high tissue iron concentrations, fibrosis and eventually cirrhosis develop [8, 38, 42, 56]. In addition, excess iron deposition in the liver is found in a variety of other disorders leading to secondary iron overload (e.g., thalassemia, chronic liver disease, porphyria cutanea tarda, sideroblastic anemia, African iron overload) [8, 26, 38, 41, 56].

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Authors
  1. B. R. Bacon
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  2. R. S. Britton
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  3. R. O’Neill
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Editor information

Editors and Affiliations

  1. Liver Research Foundation, Semmelweis University of Medicine, Szentkirályi u. 46, 1088, Budapest, Hungary

    Géza Csomós M.D.

  2. Second Department of Internal Medicine, Semmelweis University of Medicine, Szentkirályi u. 46, 1088, Budapest, Hungary

    János Fehér M.D.

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© 1992 Springer-Verlag Berlin Heidelberg

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Bacon, B.R., Britton, R.S., O’Neill, R. (1992). Lipid Peroxidation and Associated Hepatic Organelle Dysfunction in Iron Overload. In: Csomós, G., Fehér, J. (eds) Free Radicals and the Liver. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76874-3_7

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  • DOI: https://doi.org/10.1007/978-3-642-76874-3_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76876-7

  • Online ISBN: 978-3-642-76874-3

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