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Wirkungsmechanismen von LHRH-Analoga

  • L. Kiesel
  • B. Runnebaum
Conference paper
  • 13 Downloads

Zusammenfassung

Die hormonelle Steuerung der männlichen und weiblichen Gonadenfunktion unterliegt in erster Linie der Achse Hypothalamus — Hypophyse — Gonaden. Die Abbildung 1 zeigt diese endokrine Achse beim Mann. Zentralnervöse Einflüsse steuern die Bildung und Freisetzung des Luteotropin-Releasing-Hormon (LHRH) im Hypothalamus. Dieser wiederum reguliert die Funktion der Hirnanhangsdrüse (Hypophyse). Der Hypophysenvorderlappen ist an der Kontrolle der gonadalen Steroidbiosynthese beteiligt. Verschiedene positive und insbesondere negative Rückkopplungsmechanismen spielen bei der feinabgestuften Steuerung der Hormonachse eine Rolle. Das LHRH nimmt eine zentrale Bedeutung in diesem Regelkreis ein. Die vielseitigen Anwendungsmöglichkeiten des Hormons und dessen Analoga erfordern eine sorgfältige Betrachtung ihrer Wirkungsweise.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • L. Kiesel
  • B. Runnebaum

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