Modulation of Multidrug Resistance in Human Renal Cell Carcinomas
Intrinsic chemoresistance has major impact on the dismal prognosis of patients with disseminated renal cell carcinoma (RCC) in the absence of reliable therapeutic alternatives . P-170 glycoprotein was identified as a putative mechanism conferring drug resistance. Recently, a high expression of MDR 1 gene mRNA  as well as of P-170 glycoprotein [17–19] was traced in human RCCs, which may partially explain the high degree of de novo resistance. Calcium antagonists (CAs) are substances which interfere with the calcium intake at the cytoplasmatic membrane. They are mainly employed in the treatment of cardiovascular disorders such as hypertension, arrhythmia and angina pectoris. Lately, the interaction of CAs with chemotherapeutics to enhance cytotoxicity has gained particular interest. It has been shown that CAs reverse acquired resistance of experimental animal tumors  to some anticancer drugs and increase the life span of tumor-bearing animals compared to those merely treated with vinca alkaloids .
KeywordsRenal Cell Carcinoma Calcium Antagonist Vinca Alkaloid Viable Tumor Cell Human Renal Cell Carcinoma
Unable to display preview. Download preview PDF.
- 4.Cantwell B, Puamah P, Harris AL (1985) Phase I and phase II study of oral verapamil (VRP) and intravenous vindesine (VDN). Br J Cancer 52: 425Google Scholar
- 9.Hermanek P (1987) UICC, TNM Classification of malignant tumors, 4th edn. Springer, Berlin Heidelberg New York TokyoGoogle Scholar
- 10.Holm S (1979) A simple sequentially rejective multiple test procedure. Scand J Statist 6: 65–70Google Scholar
- 20.Milroy R, Connory L, Banham F, Hutcheon D, Maclntyre D, Stack B (1987) Randomized trial of verapamil in addition to chemotherapy for small cell lung cancer. Thorax 42: 209Google Scholar
- 27.Vugrin D (1987) Systematic therapy of metastatic renal cell carcinoma. Sem Nephrol 7: 152–162Google Scholar