Modulation of Multidrug Resistance in Human Renal Cell Carcinomas

  • G. H. Mickisch
  • P. M. Alken
Conference paper

Abstract

Intrinsic chemoresistance has major impact on the dismal prognosis of patients with disseminated renal cell carcinoma (RCC) in the absence of reliable therapeutic alternatives [27]. P-170 glycoprotein was identified as a putative mechanism conferring drug resistance. Recently, a high expression of MDR 1 gene mRNA [13] as well as of P-170 glycoprotein [17–19] was traced in human RCCs, which may partially explain the high degree of de novo resistance. Calcium antagonists (CAs) are substances which interfere with the calcium intake at the cytoplasmatic membrane. They are mainly employed in the treatment of cardiovascular disorders such as hypertension, arrhythmia and angina pectoris. Lately, the interaction of CAs with chemotherapeutics to enhance cytotoxicity has gained particular interest. It has been shown that CAs reverse acquired resistance of experimental animal tumors [25] to some anticancer drugs and increase the life span of tumor-bearing animals compared to those merely treated with vinca alkaloids [21].

Keywords

Lymphoma Oncol Doxorubicin Verapamil Nifedipine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • G. H. Mickisch
    • 1
  • P. M. Alken
    • 2
  1. 1.Laboratory of Molecular Biology, National Cancer InstituteNational Institutes of HealthBethesdaUSA
  2. 2.Urologische KlinikKlinikum Mannheim der Universität HeidelbergMannheimGermany

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