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Pathobiology of Renal Carcinogenesis

  • P. Bannasch
  • H. Zerban
Conference paper

Abstract

The long-standing controversy concerning the histogenesis of kidney cancer, especially the so-called hypernephroma (which was taken for a dysontogenetic tumor by Grawitz in 1883), appeared to be settled 30 years ago when Oberling and colleagues (1960) provided persuasive evidence for an origin of the hypernephroid carcinoma from the epithelium of the proximal nephron. Consequently, the term hypernephroma was replaced by renal cell carcinoma (WHO 1981). Some findings in rodents treated with chemical carcinogens seemed for a long time to support the conception of a pivotal role of the proximal nephron in the histogenesis of renal cell tumors (Lipsky and Trump 1988). However, during the past decade, several original observations in animal models (Bannasch and Zerban 1990) and a number of new findings in man (Thoenes et al. 1986; Eble 1990; Kovacs 1990) have reopened the discussion on the cellular origin, the mechanism of development, the classification, and the prognosis of renal cell tumors.

Keywords

Renal Cell Carcinoma Human Renal Cell Carcinoma Chromophobe Cell Renal Carcinoma Renal Oncocytoma Renal Cell Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • P. Bannasch
    • 1
  • H. Zerban
  1. 1.Deutsches KrebsforschungszentrumAbteilung für CytopathologieHeidelberg 1Germany

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