Skip to main content
SpringerLink
Log in

Pathobiology of Renal Carcinogenesis

  • Conference paper
Basic and Clinical Research on Renal Cell Carcinoma

Abstract

The long-standing controversy concerning the histogenesis of kidney cancer, especially the so-called hypernephroma (which was taken for a dysontogenetic tumor by Grawitz in 1883), appeared to be settled 30 years ago when Oberling and colleagues (1960) provided persuasive evidence for an origin of the hypernephroid carcinoma from the epithelium of the proximal nephron. Consequently, the term hypernephroma was replaced by renal cell carcinoma (WHO 1981). Some findings in rodents treated with chemical carcinogens seemed for a long time to support the conception of a pivotal role of the proximal nephron in the histogenesis of renal cell tumors (Lipsky and Trump 1988). However, during the past decade, several original observations in animal models (Bannasch and Zerban 1990) and a number of new findings in man (Thoenes et al. 1986; Eble 1990; Kovacs 1990) have reopened the discussion on the cellular origin, the mechanism of development, the classification, and the prognosis of renal cell tumors.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bannasch P, Zerban H (1986) Renal cell adenoma and carcinoma, rat. In: Jones TC, Mohr U, Hunt RD (eds) Monographs on pathology of laboratory animals. Urinary system. Springer, Berlin Heidelberg New York Tokyo, pp 112–139

    Google Scholar 

  • Bannasch P, Zerban H (1990) Animal models and renal carcinogenesis. In: Eble JN (ed) Tumors and tumor-like conditions of the kidney and ureters. Churchill Livingstone, New York, Edinburgh London Melbourne, pp 1–34

    Google Scholar 

  • Bannasch P, Schacht U, Storch E (1974) Morphogenese und Mikromorphologie epithelialer Nierentumoren bei Nitrosomorpholin-vergifteten Ratten. I. Induktion und Histologie der Tumoren. Z Krebsforsch 81: 311–331

    Article  CAS  Google Scholar 

  • Bannasch P, Krech R, Zerban H (1978a) Morphogenese und Mikromorphologie epithelialer Nierentumoren bei Nitrosomorpholin-vergifteten Ratten. II. Tubuläre Glykogenose und die Genese von klar-oder acidophilzelligen Tumoren. Z Krebsforsch 92: 63–86

    Article  CAS  Google Scholar 

  • Bannasch P, Krech R, Zerban H (1978b) Morphogenese und Mikromorphologie epithelialer Nierentumoren bei Nitrosomorpholin-vergifteten Ratten. III. Onkocytentubuli und Onkocytome. Z Krebsforsch 92: 87–104

    Article  CAS  Google Scholar 

  • Bannasch P, Mayer D, Krech R (1979) Neoplastische und präneoplastische Veränderungen bei Ratten nach einmaliger oraler Applikation von NNitrosomorpholin. J Cancer Res Clin Oncol 94: 233–248

    Article  PubMed  CAS  Google Scholar 

  • Bannasch P, Krech R, Zerban H (1980) Morphogenese und Mikromorphologie epithelialer Nierentumoren bei Nitrosomorpholin-vergifteten Ratten. IV. Tubuläre Läsionen und basophile Tumoren. J Cancer Res Clin Oncol 98: 243–265

    Article  PubMed  CAS  Google Scholar 

  • Bannasch P, Hacker HJ, Tsuda H, Zerban H (1986a) Aberrant regulation of carbohydrate metabolism and metamorphosis during renal carcinogenesis. Adv Enzyme Regul 25: 279–296

    Article  PubMed  CAS  Google Scholar 

  • Bannasch P, Zerban H, Hacker HJ (1986b) Oncocytoma, kidney, rat. In: Jones TC, Mohr U, Hunt RD (eds) Monographs on pathology of laboratory animals. Urinary system. Springer, Berlin Heidelberg New York Tokyo, pp 49–60

    Google Scholar 

  • Bannasch P, Nogueira E, Zerban H, Beck K, Mayer D (1988) Sequential phenotypic conversion of renal epithelial cells during neoplastic development. In: Feo F, Pani P, Columbano A, Garcea R (eds) Chemical carcinogenesis. Plenum Publishing, pp 209–216

    Google Scholar 

  • Bannasch P, Nogueira E, Zerban H (1989) Zytologie und Zytogenese experimenteller epithelialer Nierentumoren. Verh Dtsch Ges Pathol 73: 301–313

    PubMed  CAS  Google Scholar 

  • Beck K (1988) Induktion und Modulation der Entwicklung von Nierenzelltumoren der Ratte durch Streptozotocin und dessen diabetogenen Effekt. Thesis, Universität Heidelberg

    Google Scholar 

  • Berger CS, Sandberg AA, Todd JAD, Pennington RD, Haddad FS, Hecht BK, Hecht F (1986) Chromosomes in kidney, ureter, and bladder cancer. Cancer Genet Cytogenet 23: 1–24

    Article  PubMed  CAS  Google Scholar 

  • Carrol PR, Murty VVS, Reuter V, Ihanwar S, Fair WR, Whitmore WF, Chaganti RSK (1987) Abnormalities at chromosome region 3p 12–14 characterize clear cell renal carcinoma. Cancer Genet Cytogenet 26: 253–259

    Article  Google Scholar 

  • Dees JH, Reuber MD, Trump BF (1976) Adenocarcinoma of the kidney. I. Ultrastructure of renal adenocarcinomas induced in rats by N-(4’-fluoro-4biphenylyl)-acetamide. J Natl Cancer Inst 57: 779–794

    PubMed  CAS  Google Scholar 

  • De Jong B, Oosterhuis JW, Idenburg VJS, Castedo SMMJ, Dam A, Mensink HJA: Cytogenetics of 12 cases of renal adenocarcinoma. Cancer Genet Cytogenet 30: 53–61

    Google Scholar 

  • Eble JN (ed) (1990) Tumors and tumor-like conditions of the kidney and ureters. Churchill Livingstone, New York Edinburgh London Melbourne

    Google Scholar 

  • Eble JN, Hull MT (1984) Morphologic features of renal oncocytoma: A light and electron microscopic study. Hum Pathol 15: 1054–1061

    Article  PubMed  CAS  Google Scholar 

  • Grawitz P (1983) Die sogenannten Lipome der Niere. Virchows Arch 93: 39–63

    Google Scholar 

  • Gusek W (1975) Die Ultrastruktur Cycasin-induzierter Nierenadenome. Virchows Arch [A] 365: 221–237

    Article  CAS  Google Scholar 

  • Hamperl H (1962) Onkocyten and Onkocytome. Virchows Arch [A] 335: 452–483

    CAS  Google Scholar 

  • Hard GC (1986) Renal carcinogenesis, rat. In: Jones TC, Mohr U, Hunt RD (eds) Monographs on pathology of laboratory animals. Urinary system. Springer, Berlin Heidelberg New York Tokyo pp 45–49

    Google Scholar 

  • Hard GC, Butler WH (1971a) Ultrastructural aspects of renal adenocarcinoma induced in the rat by dimethylnitrosamine. Cancer Res 31: 366–372

    PubMed  CAS  Google Scholar 

  • Hard GC, Butler WH (1971b) Morphogenesis of epithelial neoplasms induced in the rat kidney by dimethylnitrosamine. Cancer Res 31: 1496–1505

    PubMed  CAS  Google Scholar 

  • Heatfield BM, Hinton DE, Trump BF (1976) Adenocarcinoma of the kidney. II. Enzyme histochemistry of renal adenocarcinomas induced in rats by N-(4’-fluoro-4-biphenylyl)-acetamide. J Natl Cancer Inst 57: 795–808

    PubMed  CAS  Google Scholar 

  • Hiasa Y, Ito N (1987) Experimental induction of renal tumors. Crit Rev Toxicol 17: 279–343

    Article  PubMed  CAS  Google Scholar 

  • Hruban Z, Mochizuki Y, Morris HP, Slesers A (1973) Ultrastructure of Morris renal tumors. J Natl Cancer Inst 50: 1487–1495

    PubMed  CAS  Google Scholar 

  • Hull MT, Eble JN (1987) Myelinoid lamellated cytoplamic inclusions in human renal adenocarcinomas: An ultrastructural study. Ultrastruct Pathol 12: 41–48

    Article  Google Scholar 

  • Ito N, Johno J, Marugami M, Konishi Y, Hiasa Y (1966) Histopathological and autoradiographic studies on kidney tumors induced by N-nitrosodimethylamine in rat. Gann 57: 595–604

    PubMed  CAS  Google Scholar 

  • Jasmin G, Riopelle JL (1969) Transplantation de trois tumeurs rénales in- duites chez le rat par la diméthylnitrosamine. Int J Cancer 4: 299–311

    Article  PubMed  CAS  Google Scholar 

  • Kovacs G (1990) Application of molecular cytogenetic techniques to the evaluation of renal parenchymal tumors. J Cancer Res Clin Oncol 116: 318–323

    Article  PubMed  CAS  Google Scholar 

  • Kovacs G, Frisch S (1989) Clonal chromosome abnormalities in tumor cells from patients with sporadic renal cell carcinomas. Cancer Res 49: 651–659

    PubMed  CAS  Google Scholar 

  • Kovacs G, Welter C, Wilkins L, Blin N, DeRiese W (1989a) Renal oncocytoma. A phenotypic and genotypic entity of renal parenchymal tumors. Am J Pathol 134: 967–971

    PubMed  CAS  Google Scholar 

  • Kovacs G, Wilkens L, Papp T, DeRiese W (1989b) Differentiation between papillary and nonpapillary renal cell carcinomas by DNA analysis. J Natl Cancer Inst 81: 527–530

    Article  PubMed  CAS  Google Scholar 

  • Krech R, Zerban H, Bannasch P (1981) Mitochondrial anomalies in renal oncocytes induced in rat by N-nitrosomorpholine. Eur J Cell Biol 25: 331–339

    PubMed  CAS  Google Scholar 

  • Krech R, Fonatsch C, Peters B, Löhrs U (1989) Morphologie and Wachstumsfraktion von Nierenzellkarzinomen des Menschen in Korrelation zu zytogenetischen Daten. Verh Dtsch Ges Pathol 73: 409–414

    PubMed  CAS  Google Scholar 

  • Lipsky MM Jr, Trump BF (1988) Chemically induced renal epithelial neoplasia in experimental animals. Int Rev Exp Pathol 30: 357–383

    PubMed  Google Scholar 

  • Mao P, Molnar JJ (1967) The fine structure and histochemistry of lead-induced renal tumors in rats. Am J Pathol 50: 571–603

    PubMed  CAS  Google Scholar 

  • Mayer D, Bannasch P (1988) Activity of glycogen synthase and phosphorylase and glucose-6-phosphate content in renal clear cell carcinomas. J Cancer Res Clin Oncol 114: 369–372

    Article  PubMed  CAS  Google Scholar 

  • Mayer D, Weber E, Kadenbach B, Bannasch P (1989) Immunocytochemical demonstration of cytochrome c oxidase as a marker for renal oncocytes and oncocytomas. Toxicol Pathol 17: 46–49

    PubMed  CAS  Google Scholar 

  • McGiven AR, Ireton HJ (1972) Renal epithelial dysplasia and neoplasia in rats given dimethylnitrosamine. J Pathol 108: 187–190

    Article  PubMed  CAS  Google Scholar 

  • Merkow LP, Epstein SM, Slifkin M, Pardo M (1973) The ultrastructure of renal neoplasms induced by aflatoxin B1. Cancer Res 33: 1608–1614

    PubMed  CAS  Google Scholar 

  • Nogueira E (1987) Rat renal carcinogenesis after chronic simultaneous exposure to lead acetate and N-nitrosodiethylamine. Virchows Arch [B] 53: 365–374

    Article  CAS  Google Scholar 

  • Nogueira E, Bannasch P (1988) Cellular origin of rat renal oncocytoma. Lab Invest 59: 337–343

    PubMed  CAS  Google Scholar 

  • Nogueira E, Klimek F, Weber E, Bannasch P (1989) Origin of renal clear cell tumors from the collecting duct. Virchows Arch [B] 57: 275–283

    Article  CAS  Google Scholar 

  • Oberling C, Rivière M, Haguenau F (1960) Ultrastructure of clear cells in renal carcinoma and its importance for the demonstration of their renal origin. Nature 186: 402–403

    Article  PubMed  CAS  Google Scholar 

  • Ortmann M, Vierbuchen M, Fischer R (1988a) Renal oncocytoma. II. Lectinand immunohistochemical features indicating an origin from the collecting duct. Virchows Arch [B] 56: 175–184

    Article  CAS  Google Scholar 

  • Ortmann M, Vierbuchen M, Koller G, Fischer R (1988b) Renal oncocytoma. I. Cytochrome c oxidase in normal and neoplastic renal tissue as detected by immunohistochemistry — a valuable aid to distinguish oncocytomas from renal cell carcinomas. Virchows Arch [B] 56: 165–173

    Article  CAS  Google Scholar 

  • Störkel SB, Pannen B, Thoenes W, Steart PV, Wagner S, Drenckhahn D (1988a) Intercalated cells as a probable source for the development of renal oncocytoma. Virchows Arch [B] 56: 185–189

    Article  Google Scholar 

  • Störkel S, Steart PV, Drenckhahn D, Thoenes W (1988b) The human chromophobe cell renal carcinoma — its probable relation to intercalated cells of the collecting duct. Virchows Arch [B] 56: 237–245

    Article  Google Scholar 

  • Teyssier JR, Henry I, Dozier C, Ferre D, Adnet JJ, Pluot M (1986) Recurrent deletion of the short arm of chromosome 3 in human renal cell carcinoma: shift of the c-raf 1 locus. J Natl Cancer Inst 77: 1187–1195

    PubMed  CAS  Google Scholar 

  • Thoenes W, Störkel S, Rumpelt H-J (1985) Human chromophobe cell renal carcinoma. Virchows Arch [B] 48: 207–217

    Article  CAS  Google Scholar 

  • Thoenes W, Störkel S, Rumpelt H-J (1986) Histopathology and classification of renal cell tumors (adenomas, oncocytomas, and carcinomas). The basic cytological and histopathological elements and their use for diagnostics. Pathol Res Pract 181: 125–143

    Article  PubMed  CAS  Google Scholar 

  • Thoenes W, Störkel S, Rumpelt H-J, Moll R, Baum HP, Werner S (1988) Chromophobe cell renal carcinoma and its variants — a report on 32 cases. J Pathol 15.5: 277–287

    Article  Google Scholar 

  • Tsuda H, Hacker HJ, Katayama H, Masui T, Ito N, Bannasch P (1985) Correlative histochemical studies on preneoplastic and neoplastic lesions in the kidney of rats treated with nitrosamines. Virchows Arch [B] 51: 385–404

    Article  Google Scholar 

  • Van der Walt JD, Reid HAS, Risdon RA, Shaw HF (1983) Renal oncocytoma. A review of the literature and report of an unusual multicentric case. Virchows Arch [A] 398: 291–304

    Article  Google Scholar 

  • Weber G (1980) Enzymic programs of human renal adenocarcinoma. In: Sufrin G, Beckley SA (eds) Renal adenocarcinoma. UICC Publications, Geneva, pp 44–50

    Google Scholar 

  • WHO (1981) International histological classification of tumours. In: Mostofi FK, Sesterhenn JA, Sobin LH (eds) Histological typing of kidney tumours, Vol 25

    Google Scholar 

  • Yoshida MA, Ohyashiki K, Ochi H, Gibas Z, Pontes JE, Prout GR, Sandberg AA (1986) Cytogenetic studies of tumor tissue from patients with non-familial renal cell carcinomas. Cancer Res 46: 2139–2147

    PubMed  CAS  Google Scholar 

  • Zerban H, Nogueira E, Riedasch G, Bannasch P (1987) Renal oncocytoma: origin from the collecting duct. Virchows Arch [B] 52: 375–387

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Deutsches Krebsforschungszentrum, Abteilung für Cytopathologie, Im Neuenheimer Feld 280, W-6900, Heidelberg 1, Germany

    P. Bannasch

Authors
  1. P. Bannasch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Zerban
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Abteilung Urologie und Poliklinik Klinikum, Ruprecht-Karls-Universität, Im Neuenheimer Feld 110, W-6900, Heidelberg, Germany

    Gerd Staehler  & Sigmund Pomer  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Bannasch, P., Zerban, H. (1992). Pathobiology of Renal Carcinogenesis. In: Staehler, G., Pomer, S. (eds) Basic and Clinical Research on Renal Cell Carcinoma. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76863-7_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-76863-7_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76865-1

  • Online ISBN: 978-3-642-76863-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation