Tumor Infiltrating Lymphocytes in Renal Cell Cancer

  • G. P. Haas
  • J. E. Pontes
  • A. Belldegrun
Conference paper

Abstract

For the past decade the immunotherapy approach to the treatment of solid cancers resistant to conventional treatment modalities has proven to be of benefit, particularly in melanoma and metastatic renal cell cancer. Cancer patients were treated with the lymphokine interleukin-2 (IL-2) alone, or in combination with other lymphokines in order to activate the patient’s immune system against the cancer. Alternatively, autologous circulating lymphocytes obtained by leukapheresis of the patient were activated and expanded with IL-2 in vitro, leading to the generation of lymphokine-activated killer (LAK) cells. These LAK cells capable of mediating a high degree of antitumor activity were reinfused to the patients in combination with IL-2 administration, thus providing the patient with a large pool of killer cells. Following LAK cell therapy for renal cell cancer 35% partial and complete response rates have been achieved with many durable responses and several patients who are still in remission after 3 years [21].

Keywords

Toxicity Ischemia Chromium Oncol Interferon 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • G. P. Haas
    • 1
  • J. E. Pontes
    • 1
  • A. Belldegrun
    • 2
  1. 1.Section of Urological Oncology, Department of UrologyWayne State University, School of MedicineDetroitUSA
  2. 2.Cancer Immunotherapy Program School of MedicineJonsson Comprehensive Cancer CenterLos AngelesUSA

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