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Differentialdiagnose der primären Knochenmarkinsuffizienz

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Diagnostische Hämatologie

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Zusammenfassung

Aplastische Anämien (aA) und myelodysplastische Syndrome (MDS) sind Erkrankungen des hämopoetischen Stammzellsystems. Zum Verständnis der Erkrankungen werden zunächst einige physiologische Grundlagen der Regulation der Hämopoese dargestellt. Sodann wird die Differentialdiagnose der betreffenden Krankheitsbilder diskutiert und die spezielle Problematik der Erkrankungen besprochen.

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Literatur

  1. Alter BP (1987) The bone marrow failure syndromes. In: Nathan DG, Oski FA (ed) Hematology of infancy and childhood. Philadelphia, Saunders, 1987, P 159

    Google Scholar 

  2. Alter BP, Knobloch ME, Weinberg RS (1991) Erythropoiesis in Fanconi’s anemia. Blood 78:602–608

    Google Scholar 

  3. Alter BP, Nathan DG (1979) Red cell aplasia in children (annotation). Arch Dis Child 54:263

    Article  PubMed  CAS  Google Scholar 

  4. Amato D, Khan NR (1983) Erythroid burst formation in cultures of bone marrow and peripheral blood from patients with refractory anemia. Acta haemat 70: 1

    Article  PubMed  CAS  Google Scholar 

  5. Ammus SS, Yunis AA (1987) Acquired pure red cell aplasia. Am J Hematol 24:326

    Article  Google Scholar 

  6. Anagnostou A, Kurztman NA (1986) Hematological consequences of renal failure. In: Brenner, Rector, The kidney, p 1631 (Saunders, Philadelphia)

    Google Scholar 

  7. Aoki Y (1980) Multiple enzymatic defects in mitochondria in hematological cells of patients with primary sideroblastic anemia. J Clin Invest 66:43

    Article  PubMed  CAS  Google Scholar 

  8. Aoki Y, Muranaka S, Nakabayashi K, Veda Y (1979) delta-aminolevulinic acid synthetase in erythroblasts of patients with pyridoxine - responsive anemia. Hypercatabolism caused by the increased susceptibility to the controlling protease. J Clin Invest 64: 1196

    Google Scholar 

  9. Appelbaum FR, Barrall J, Storb J et al. (1987) Clonal cytogenetic abnormalities in patients with otherwise typical aplastic anemia. Exp Hematol 15: 1134

    PubMed  CAS  Google Scholar 

  10. Appelbaum FR, Storb B, Ramberg RE et al (1987) Treatment of preleukemic syndromes with marrow transplantation. Blood 69:92

    PubMed  CAS  Google Scholar 

  11. Ascensao JL, Kay NE, Wright JJ et al (1986) Lymphoblastic transformation of myelodysplastic syndrome. Am J Haematol 22:431

    Article  CAS  Google Scholar 

  12. Auerbach AD, Rogatko A, Schröder-Kurth TM (1989). International Fanconi anemia registry: relation of clinical symptoms to diepoxybutane sensitivity. Blood 73:391–396

    PubMed  CAS  Google Scholar 

  13. Ayanlar-Batuman O, Shevitz Y, Traub UC et al (1987) Lymphocyte interleukin 2 production and responsiveners are altered in patients with primary myelodysplastic syndromes. Blood 70:494

    Google Scholar 

  14. Barbacid M (1987) ras genes. Ann Rev Biochem 56:779–827

    Google Scholar 

  15. Barosi G, Cazzola M, Morandi S et al (1978) Estimation of ferrokientic parameters by a mathematical model in patients with primary acquired sideroblastic anaemia. Br J Haematol 39:409

    Article  PubMed  CAS  Google Scholar 

  16. Bartelmez SH, Stanley RE (1985) Synergism between hemopoietic growth factors (HGFs) detected by their effects on cells bearing receptor for a lineage specific HGF: assay of hemopoietin-1. J. Cell. Physiol. 122:370

    Article  PubMed  CAS  Google Scholar 

  17. Bauer J, Gantner V, Geiger T, Jacobshagen V, Hirano T, Matsuda T, Kishimoto T, Andus T, Acs G, Gerok W (1988) Regulation of interleukin-6 expression in cultured human blood monocytes and monocyte-derived macrophages. Blood 72: 1134

    Google Scholar 

  18. Baumann MA, Keller RH, McFadden PW (1986) Myeloid cell surface phenotype in myelodysplasia: Evidence for abnormal persistence of an early myeloid differentiation antigen. Am J Haematol 22:251

    Article  CAS  Google Scholar 

  19. Ben-Bassast I, Brok-Simoni F, Ramot B (1975) Complement-sensitive red cells in aplastic anemia. Blood 46:357–361

    Google Scholar 

  20. Bennett JM, Catovsky D, Daniel MT et al (1982) Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 51: 189

    PubMed  CAS  Google Scholar 

  21. Bergsagel DE, Bailcy AJ, Langley GR et al (1979) The chemotherapy of plasma-cell myeloma and the incidence of acute leukemia. N Engl J Med 301:743

    Article  PubMed  CAS  Google Scholar 

  22. Bernard DL, Burns GF, Gordon J et al (1979) Chronic myelomonocytic leukemia with paraproteinaemia but no detectable plasmacytosis. Cancer 44:927

    Article  Google Scholar 

  23. Bessis MC, Jensen WN (1965) Sideroblastic anaemia, mitochondria and erythroblastic iron. Br J Haematol 11:49

    Article  PubMed  CAS  Google Scholar 

  24. Bloomfield CD (1986) Chromosome abnormalities in secondary myelodysplastic syndromes. Scand J Haematol 36, Suppl 45:82

    CAS  Google Scholar 

  25. Bos JL, Verlaan de Vries M, van der Eb AJ et al (1987) Mutations in N-ras predominate in acute mycloid leukemia. Blood 69:1237

    PubMed  CAS  Google Scholar 

  26. Bos JL (1990): ras mutations and human cancer. In: Molecular Genetics in Cancer Diagnosis. J. Cossman (ed.) Elsevier 1990

    Google Scholar 

  27. Bradley TR, Metcalf D (1966) The growth of mouse bone marrow cells in vitro. Austr. J. Exp. BioI. Med 44:287

    Article  CAS  Google Scholar 

  28. Breton-Gorius J (1979) Abnormalities of granulocytes and megakaryocytes in preleukemic syndromes. In: Schmalzl F, Hellriegl KP (eds) Preleukemia. Springer Berlin Heidelberg New York p 24ff

    Google Scholar 

  29. Broudy VC, Harlan JM, Adamson JW (1987) Disparate effects of tumor necrosis factor-alpha/cachectin and tumor necrosis factor-β/lymphotoxin on hematopoietic growth factor production and neutrophil adhesion molecule expression by cultured endothelial cells. J Immunol138:4298–4302

    Google Scholar 

  30. Broxmeyer HE, Lu L, Platzer E, Feit C, Juliano L, Rubin BY (1983) Comparative analysis of the influence of human gamma, alpha and beta interferons on human multipotential (CFU-GEMM), erythroid (BFU-e) and granulocyte-macrophage (CFU-GM) progenitor cells. J Immunol 131: 1300

    PubMed  CAS  Google Scholar 

  31. Broxmeyer HE, Williams DE, Lu L, Cooper S, Anderson SL, Beyer GS, Hoffman R, Rubin BY (1986) The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia. Synergism of tumor necrosis factor and interferon-gamma. J Immuno1 136:4487

    CAS  Google Scholar 

  32. Broxmeyer HE, Lu L, Cooper S, Tushinski R, Mochizuki D, Rubin BJ, Gillis S, Williams DE (1988) Synergistic effects of purified recombinant human and murine BCell growth factor-l/IL-4 on colony formation in vitro by hematopoietic progenitor cells: multiple actions. J. ImmunoI 141:3852–3862

    CAS  Google Scholar 

  33. Camitta BM, Storb R, Thomas ED (1982a) Aplastic anemia. N Engl J Med 306:645–652

    Article  PubMed  CAS  Google Scholar 

  34. Camitta BM, Strob R, Thomas ED (1982b) Aplastic anemia. N Engl J Med 306:712–718

    Article  PubMed  CAS  Google Scholar 

  35. Carbonell F, Heimpel H, Kubanek B, Fliedner TM (1985) Growth and cytogenetic characteristics of bone marrow colonies from patients with 5q-syndrome. Blood 66:463

    PubMed  CAS  Google Scholar 

  36. Cartwright GE, Deiss A (1975) Sideroblasts, siderocytes and sideroblastic anemia. N Engl J Med 292: 185

    Article  PubMed  CAS  Google Scholar 

  37. Casciato D, Scott JC (1979) Acute leukemia following prolonged cytotoxic agent therapy. Medicine (Baltimore) 58:32

    Article  CAS  Google Scholar 

  38. Cazzola M, Barosi G, Berznini C et al (1982) Quantitative evaluation of erythropoietic activity in dysmyelopoietic syndromes. Br J Haematol 50:55

    Article  PubMed  CAS  Google Scholar 

  39. Cervenka J, Arthur D, Yasis C (1981) Mitomycin C test for diagnostic differentiation of idiopathic aplastic anemia. Pediatrics 67: 119

    PubMed  CAS  Google Scholar 

  40. Champlin RE, Horowitz MM, van Bekkum DW, Camitta BM, Elfenbein GE, Gale RP, Gluckman E, Good RA, Rimm AA, Rozman C, Speck B, Bortin MM (1989) Graft failure following bone marrow transplantation for severe aplastic anemia: Risk factors and treatment rcsults. Blood 73:606–613

    PubMed  CAS  Google Scholar 

  41. Cheng DS, Kushner JP, Wintrobe MM (1979) Idiopathic refractory sideroblastic anemia. Cancer 44: 724

    Article  PubMed  CAS  Google Scholar 

  42. Cohen JR, Creger WP, Greenberg PL, Schrier SL (1979) Subacute myeloid leukemia. A clinical review. Am J Med 66:959

    Article  PubMed  CAS  Google Scholar 

  43. Coiffier B, Adeleine P, Viala JJ et al (1983) Dysmyelopoietic syndromes. A search for prognostic factors in 193 patients. Cancer 555:83

    Google Scholar 

  44. Copplestone JA, Mufti GJ, Hamblin TJ, Oscier G (1986) Immunological abnormalities in myelodysplastic syndromes: II. Coexistent lymphoid or plasma cell neoplasms: A report of 20 cases unrelated to chemotherapy. Br J Haematol 63: 149

    Article  PubMed  CAS  Google Scholar 

  45. Crawford RM, Finbloom DS, Ohara J, Paul WE, Meltzer MS (1987) B cell stimulatory factor 1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of la antigens. J Immunol139: 135–141

    Google Scholar 

  46. Dacie JV, Mollin DL (1966) Siderocytes, sideroblasts, and sideroblastic anaemia. Acta Med Scand [Suppl] 179/445:237

    Google Scholar 

  47. Davis RL (1983) Aplastic crisis in hemolytic anemias: The role of a parvovirus-like agent. Annotation Brit J Haematol 55:391

    Article  CAS  Google Scholar 

  48. De Planque MM, Klein-Nelemans JC, van Krieken HJM (1989) Evolution of acquired severe aplastic anemia to myelodysplasia and subsequent leukemia in adults. Br J Haematol. 73:121

    Article  PubMed  Google Scholar 

  49. Desevilla E, Forrest JV, Zivnusksa FR, Sagel SS (1975) Metastatic thymoma with myasthenia gravis and pure red cell aplasia. Cancer 36: 1145

    Google Scholar 

  50. Dessypris EN, Baer MR, Sergent JS, Krantz SB (1984) Rheumatoid arthritis and pure red cell aplasia. Ann Int Med 100:202

    PubMed  CAS  Google Scholar 

  51. Dessypris EN, Redline S, Harris HW, Krantz SB (1985) Diphenylhydantoin-induced pure red cell aplasia. Blood 65:789

    PubMed  CAS  Google Scholar 

  52. Dexter TM, Allen TD, Lajtha LG (1977) Conditions controlling the proliferation of haemopoietic stem cell proliferation in vitro. J Cell Physiol 91:335

    Article  PubMed  CAS  Google Scholar 

  53. Dezza L, Cazzola M, Bergamaschi G (1983) Myelodysplastic syndrome with monosomy 7 in adulthood: a distinct preleukaemic disorder. Haematologica 68: 723

    PubMed  CAS  Google Scholar 

  54. Diamond LK, Wang WC, Alter BP (1976) Congenital hypoplastic anemia. Adv Pediatr 22: 249

    Google Scholar 

  55. Boran HM, Treall AG (1988) (Case report) Neutropenia accompanying erythroid aplasia in human parvovirus infection. Brit J Haematol 69:287

    Google Scholar 

  56. Dresch C, Faille A, Glogowski A, Najean Y (1977) Elements du prognostic des dysplasies hematopoietiques. Nouv Rev Fr Hematol 18:401

    CAS  Google Scholar 

  57. Eichner ER, Hillman RS (1971) The evolution of anemia in alcoholic patients. Am J Med 50:218

    Article  PubMed  CAS  Google Scholar 

  58. Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW (1987) Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. N Engl J Med 316:73–78

    Article  PubMed  CAS  Google Scholar 

  59. Fauser AA, Messner HA (1979) Identification of megakaryocytes, macrophages, and eosinophils in colonies of human bone marrow containing neutrophilic granulocytes and erythroblasts. Blood 53: 1023

    PubMed  CAS  Google Scholar 

  60. Fohlmeister J, Fischer R, MOdder B et al (1985) Aplastic anaemia and the hypocellular myelodysplastic syndrome: histomorphological, diagnostic, and prognostic features. J Clin Pathol 38: 1218

    Article  PubMed  CAS  Google Scholar 

  61. Foucar K, Langdon RM, Armitage JO et al (1985) MDS: A clinical and pathologic analysis of 109 cases. Cancer 56:553

    Article  PubMed  CAS  Google Scholar 

  62. Francis DA (1982) Pure red cell aplasia: Association with systemic lupus erythematodus and primary immune hypothyroidism. Brit Med J 284:85

    Article  CAS  Google Scholar 

  63. Francis GE, Miller EJ, Wonke B et al (1983) Use of bone marrow culture in prediction of acute leukaemic transformation in preleukemia. Lancet 1:627

    Google Scholar 

  64. Frisch B, Bartl R (1986) Bone marrow histology in myelodysplastic syndromes. Scand J Haematol 36, Suppl 45:21

    CAS  Google Scholar 

  65. Frisch B, Bartl R (1986) Bone marrow histology in myelodysplastic syndromes. Scand J Haematol 36, Suppl 45:21

    CAS  Google Scholar 

  66. Frisch B, Bartl R, Chaichik S (1986b) Therapy-induced myelodysplasia and secondary leukaemia. Scand J Haematol 36, Sup pi 45:38

    CAS  Google Scholar 

  67. Frisch B, Lewis SM (1974) The bone marrow in aplastic anaemia. J Clin Pathol 27:231

    Article  PubMed  CAS  Google Scholar 

  68. Galton DAG (1986) The myelodysplastic syndromes. Scand J Haematol 36, Suppl 45: 11

    CAS  Google Scholar 

  69. Geary CG (1987) Myelodysplasia: Morphology, clinical presentation and treatment In: Leukaemia, Whittaker JA, Delamore IW (eds). Blackwell Scientific Publications p 420

    Google Scholar 

  70. Geary CG, Catovsky D, Wiltshaw E et al (1975) Chronic myelomonocytic leukemia. Br J Haematol 30:289

    Article  PubMed  CAS  Google Scholar 

  71. German J, Ray JH (1988) A test for Fanconi’s anemia. Blood 72:367

    Google Scholar 

  72. German J, Schonberg S, Caskie S, Warburton D, Falk C, Ray JH (1987) A test for Fanconi’s anemia. Blood 69: 1637–1641

    PubMed  CAS  Google Scholar 

  73. Glanz A, Fraser FC (1982) Spectrum of anomalies in Fanconi anaemia. J Med Genet 19:412

    Article  PubMed  CAS  Google Scholar 

  74. Gluckman E, Devergie A, Schaison G, Bussel A, Berger R, Sohier J, Bernard J (1980) Bone marrow transplantation in Fanconi anemia. Brit J Haemat 45:557

    Article  PubMed  CAS  Google Scholar 

  75. Goodman JR, Hall SG (1967) Acammulation of iron in mitochondria of erythroblasts. Br J Haematol 13:335

    Article  PubMed  CAS  Google Scholar 

  76. Greenberg BR, Miller C, Cardiff RD et al (1983) Concurrent development of preleukaemic, lymphoproliferative and plasma cell disorders. Br J Haematol 53: 125

    Article  PubMed  CAS  Google Scholar 

  77. Greenberg PL (1983) The smouldering leukemic states: clinical and biologic features. Blood 61: 1035

    PubMed  CAS  Google Scholar 

  78. Hapel AJ, Fung MC, Johnson RM, Young IG, Johnson G, Metcalf D (1985) Biologic properties of molecularly cloned and expressed murine interleukin-3. Blood 65:1453

    PubMed  CAS  Google Scholar 

  79. Hast R (1986)Sideroblasts in myelodysplasia: their nature and clinical significance. Scand J Haematol 36, Suppl 45: 53

    Google Scholar 

  80. Hast R, Reizenstein P (1977) Studies on human preleukemia: I. Erythroblast and iron kinetics in aregenerative anaemia with hypercellular bone marrow. Scand J Haematol 19:347

    Article  PubMed  CAS  Google Scholar 

  81. Hast R, Berau M, Grauberg I (1979) Studies on human preleukemia: prognostic factors for the preleukemic stage in a regenerative anemia with hypercellular bone marrow. In: Schmalzl F, Hellriegel KP (eds) Preleukemia. Springer Berlin Heidelberg New York p 113

    Google Scholar 

  82. Heilmeyer L (1970) Die Hypochromanämien. In: Heilmeyer L (Hrsg) Klinik des erythrocytären Systems,S. Auflage. Springer Berlin Heidelberg New York. Handbuch der Inneren Medizin, Bd 2/2, S 14

    Google Scholar 

  83. Hellriegel KP, Fohlmeiser I, Schafer HE (1979) Aplasic anemia terminating in leukemia. In: Heimpel H, Gordon-Smith EC, Heit W, Kubanek B (eds) Aplastic anemia: Pathophysiology and approaches to therapy. Springer Verlag, Berlin, pp 47–51

    Chapter  Google Scholar 

  84. Hines JD (1969) Reversible megaloblastic and sideroblastic marrow abnormalities in alcoholic patients. Br J Haematol 16:87

    Article  PubMed  CAS  Google Scholar 

  85. Hinterberger W, Adolf G, Aichinger G et al. (1988) Further evidence for lymphokine overproduction in severe aplastic anemia. Blood 72:266

    PubMed  CAS  Google Scholar 

  86. Hirai H, Kobayaski Y, Mano H et al (1987) A point mutation at codon 13 of the Nras oncogene in myelodysplastic syndrome. Nature 327:430

    Article  PubMed  CAS  Google Scholar 

  87. Hodgkin PD, Bond MW, O’Garra A, Frank G, Lee F, Coffman RL, Zlotnik A, Howard M (1988) Identification of IL-6 as a T cell-derived factor that enhances the proliferative response of thymocytes to IL-4 and phorbol myristate acetate. J Immunol 141: 151–157

    PubMed  CAS  Google Scholar 

  88. Hoffman R. McPhedran P, Benz EJ, Duffy TP (1983) Isoniazide pure red cell aplasia. Am J Med Sci 286:2

    Article  PubMed  CAS  Google Scholar 

  89. Hows JM (1991) Severe aplastic anaemia: the patient without a HLA-identical sibling. Brit J Haematol 77:1–4

    Article  CAS  Google Scholar 

  90. Hunter RF, Mold NG, Mitchell RB, Huang AT (1985) Differentiation of normal marrow and HL60 cells induced by anti thymocyte globulin. Proc Nat! Acad Sci USA 82:4823

    Article  CAS  Google Scholar 

  91. International agranulocytosis and aplastic anemia study (1983) The design of a study of the drug etiology of agranulocytosis and aplastic anemia. Eur J Clin Pharmacol 24:883

    Google Scholar 

  92. International agranulocytosis and aplastic anemia study (1987) Incidence of aplastic anemia: The relevance of diagnostic criteria. Blood 70:1718–1721

    Google Scholar 

  93. Jacobs A (1985) Myelodysplastic syndromes: pathogenesis, functional abnormalities and clinical implications. J Clin Pathol 38: 1201

    Article  PubMed  CAS  Google Scholar 

  94. Jacobs A (1991) Genetic Lesions in Preleukemia. Leukemia 5:277

    PubMed  CAS  Google Scholar 

  95. Jacobs RH, Cornbleet MA, Vardiman JW et al (1986) Prognostic implications of morphology and karyotype in primary meylodysplastic syndromes. Blood 67: 1765

    PubMed  CAS  Google Scholar 

  96. Janssen JWG, Steenvoorden ACM, Lyons J, Anger B, Bohlke JV, Seliger H, Bartram CR (1987) RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes. Proc Natl Acad Sci USA 84: 9228–9232

    Article  PubMed  CAS  Google Scholar 

  97. Jeune FS, Good RA (1968) Thymoma, immunologic deficiencies and hematologic abnormalities. In: Good RA (ed) Birth defects, vol. 4. The National Foundation, New York, p 192

    Google Scholar 

  98. Juneja SK, Imbert M, Sigaux F (1983a) Prevalence and distribution of ringed sideroblasts in primary myelodysplastic syndromes. J Clin Pathol 36:566

    Article  PubMed  CAS  Google Scholar 

  99. Juneja SK, Imbert M, Jounault H et al (1983b) Haematological features of primary myelodysplastic syndromes (PMDS) at initial presentation: a study of 118 cases. J Clin Pat hoi 36: 1129

    Article  CAS  Google Scholar 

  100. Kaiser TN, Lojewski A, Dougheerty C, Jürgens L, Saher E, Latt SA (1982) Flow cytometric characterization of the response of Fanconi’s anemia cells to mitomycin C treatment. Cytometry 2:291

    Article  PubMed  CAS  Google Scholar 

  101. Kaplan HS (1980) Hodgkin’s disease, 2nd edn. Harvard University Press, Cambridge

    Google Scholar 

  102. Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato K, Asaoka H, Tang B, Tanabe O, Tanake H (1988) Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 332:83–85

    Article  PubMed  CAS  Google Scholar 

  103. Keitt AS (1988) Anemia due to bone marrow failure. In: Cecil Textbook of Medicine. Wyngaarden JB u. Smith LH, Herausgeber, Saunders Philadelphia.

    Google Scholar 

  104. Keller JR, Mantel C, Sing GK, Ellingsworth LR, Ruscetti SK, Ruscetti FW (1988) Transforming growth factor β1 selectively regulates early murine hematopoietic progenitors and inhibits the growth of IL-3-dependent myeloid leukemia cell lines. J Exp Med 168:737–750

    Article  PubMed  CAS  Google Scholar 

  105. Kerkhofs H, Hagemejer A, Leeksma CH et al (1982) The 5q chromosome abnormality in haematological disorders: a collaborative study of 34 cases from the Netherlands. Br J Haematol 52: 365

    Article  PubMed  CAS  Google Scholar 

  106. Kerkhofs H, Hermans J, Haak HL, Leeksma CH (1987) Utility of the FAB classification for myelodysplastic syndromes: investigation of prognostic factors in 237 cases. Br J Haematol 65:73

    Article  PubMed  CAS  Google Scholar 

  107. Konopka L, Hoffbrand A V (1979) Haem synthesis in sideroblastic anaemia. Br J Haematol42:73

    Google Scholar 

  108. Konwalinka G, Huber C, Tomaschek B, Peschel C, Geissler D, Odavic R, Braunsteiner H (1983) A case of acquired pure red cell anemia studied by cloning of erythroid progenitor cells in vitro. Acta Haematol 70:316

    Article  PubMed  CAS  Google Scholar 

  109. Konwalinka G, Peschel C, Schmalzl F et al (1985) CFU-GM assay, cytochemical and electron microscopic studies in agar in patients with preleukemic syndrome and aplastic anemia. Int J Cell Cion 3:367

    Article  CAS  Google Scholar 

  110. Krantz S (1976) Diagnosis and treatment of pure red cell aplasia. Med Clin North A 60:945

    CAS  Google Scholar 

  111. Krantz SB, Moor WH, Säntz SO (1972) Studies on pure red cell aplasia. V. Presence of erythroblast cytotoxicity in red cell globulin fraction of plasma. J Clin Invest 52:324

    Article  Google Scholar 

  112. Kurtzmann GJ, Ozawa K, Cohen B, Hanson G, Oseas R, Moung NS (1987) Chronic bone marrrow failure due to persistent B 19 parvovirus infection. N Engl J Med 317:287

    Article  Google Scholar 

  113. Kushner YP, Lee GR, Wintrobe MM, Cartwright GE (1971) Idiopathic refractory sideroblastic anemia. Medicine (Baltimore) 50:139

    Google Scholar 

  114. Lajtha LG (1979) Stem cell concepts. Differentiation 14:23

    Article  PubMed  CAS  Google Scholar 

  115. Law IP, Blom J (1980) Second malignancies in patients with multiple myeloma. Oncology 34:20

    Article  Google Scholar 

  116. Lazarus KH, Bahner RL (1981) Aplastic anemia complicating infectious mononucleosis: a case report and review of the literature. Pediatrics 67:907

    PubMed  CAS  Google Scholar 

  117. Le J, Weinstein D, Gubler U, Vilcek J (1987) Induction of membrane-associated interleukin 1 by tumor necrosis factor in human fibroblasts. J Immunol 138:2137

    PubMed  CAS  Google Scholar 

  118. Leary AG, Ikebuchi K, Hirai Y, Wong GG, Yang YC, Clark SC, Ogawa M (1988) Synergism between Interleukin-6 and Interleukin-3 in supporting proliferation of human hematopoietic stem cells: Comparison with Interleukin-la. Blood 71: 1759–1763

    PubMed  CAS  Google Scholar 

  119. Le Beau MM, Albain KS, Larson RA et al (1986a) Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute nonlymphocytic leukemia: Further evidence for characteristic abnormalities of chromosomes No 5 and 7. J Clin Oncol 4:325

    PubMed  Google Scholar 

  120. Le Beau MM, Pettenati MJ, Lemons RS, Diaz MO, Westbrook CA, Larson RA, Sherr CJ, Rowley JD (1986b) Assignment of the GM-CSF, CSF-l, and FMS genes to human chromosome 5 provides evidence for linkage of a family of genes regulating hematopoiesis and for their involvement in the deletion 5q in myeloid disorders. Cold Spring Harbor Symp. Quant. BioI. 51:899

    Google Scholar 

  121. Lewis SM (1965) Course and prognosis in aplastic anemia. Br Med J 1:1027

    Article  PubMed  CAS  Google Scholar 

  122. Lintula R (1986a) Ferrokinetic abnormalities and red cell life span in myelodysplastic syndromes: A review. Scand J Haematol 36, Suppl 45:48

    Google Scholar 

  123. Lintula R (1986b) Red cell enzymes in myelodysplastic syndromes. Scand J Haematol 36, Suppl 45: 56

    CAS  Google Scholar 

  124. Losowsky MS, Hall R (1965) Hereditary sideroblastic anaemia. Br J Haematol ll:70

    Google Scholar 

  125. Lynch RE, Williams DM, Reading JC, Cartwright GE (1975) The prognosis in aplastic anemia. Blood 45:517–528 116. Mangan KF (1985) T cell mediated suppression of hematopoiesis. N Engl J Med 312:306–307

    Google Scholar 

  126. Mangan K, D’Alessandro L (1985) Hypoplastic anemia in B cell chronic lymphocytic leukemia. Evolution of T cell mediated suppression of erythropoiesis in early stages and late stage disease. Blood 66:533

    PubMed  CAS  Google Scholar 

  127. Mangan KF, Chikkappa G, Farle P (1982) T gamma (T8) cells suppress growth of erythroid colony forming units in vitro in the pure red cell aplasia of B-cell chronic lymphocytic leukemia. J Clin Invest 70: 1148

    Article  PubMed  CAS  Google Scholar 

  128. Mangan KF, Besa EX, Shadduk RK, Tedrow H, Ray PK (1984) Demonstration of two distinct antibodies in autoimmune hemolytic anemia with reticulocytopenia and red cell aplasia. Exp Haematol 12:788

    CAS  Google Scholar 

  129. Manoharan A, Catovsky D, Clein P et al (1981) Simultaneous or spontaneous occurence of lympho- and myeloproliferative disorders: a report of four cases. Br J Haematol 48: 111

    Article  PubMed  CAS  Google Scholar 

  130. Marmont AM, Bacigalupo A (1988) Aplastic anemia: Pathogenesis and treatment. Haematologica 73: 133–141

    PubMed  CAS  Google Scholar 

  131. Marsh JCW, Hows JM, Bryett KA, Al-Hashimi S, Fairhead SM, Gordon-Smith EC (1987) Survival after antilymphocyte globulin therapy for aplastic anemia depends on disease severity. Blood 70: 1046–1052

    PubMed  CAS  Google Scholar 

  132. Marsh JCW, Chang J, Testa NG, Hows JM, Dexter TM (1990) The hematopoietic defect in aplastic anemia assessed by longterm marrow culture. Blood 76:1748–1757

    PubMed  CAS  Google Scholar 

  133. May A, de Souza P, Barnes K et al (1982) Erythroblast iron metabolism in sideroblastic marrows. Br J Haematol 52:611

    Article  PubMed  CAS  Google Scholar 

  134. May SJ, Smith SA, Jacobs A et al (1985) The myelodysplastic syndrome: analysis of laboratory characteristics in relation to the FAB classification. Br J Haematol 59:311

    Article  PubMed  CAS  Google Scholar 

  135. Mc Gibbon BH, Mollin DL (1965) Sideroblastic anaemia in man: Observation on seventy cases. Br J Haematol 11:59

    Article  Google Scholar 

  136. Mc Kenna RW, Parkin JL, Foucar K, Brunning RD (1981) Ultrastructural characteristics of therapy-related acute non lymphocytic leukemia: Evidence for a panmyelosis. Cancer 48: 725

    Article  Google Scholar 

  137. Metcalf D (1985) The granulocyte-macrophage colony-stimulating factors. Science 229:16–22

    Article  PubMed  CAS  Google Scholar 

  138. Michels SD, Mc Kenna RW, Arthur DC, Brunning RD (1985) Therapy-related acute myeloid leukemia and myelodysplastic syndrome: A clinical and morphologic study of 65 cases. Blood 65: 1364

    PubMed  CAS  Google Scholar 

  139. Milner GR, Testa NG, Geary CG et al (1977) Bone marrow culture studies in refractory cytopenia and smouldering leukaemia. Br J Haematol 35:251

    Article  PubMed  CAS  Google Scholar 

  140. Mollin DL (1965) Introduction: Sideroblasts and sideroblastic anaemia. Br J Haematol 11:41

    Article  PubMed  CAS  Google Scholar 

  141. Moore MAS (1991) Clinical implications of positive and negative hematopoietic stemcell regulators. Blood 78:1–19

    PubMed  CAS  Google Scholar 

  142. Morra L, Ponassi AG, Gurreri G, Moccia F, Mela GS, Bogliolo F, Beltrai P, Sacchetti C (1988) Inadequate ability of T-lymphocytes from chronic uremic subjects to stimulate the in vitro growth of committed erythroid progenitors (BFU-E). Acta haemat 79: 187–191

    Article  PubMed  CAS  Google Scholar 

  143. Morrissey PJ, Goodwin RG, Nordan RP, Anderson D, Grabstein KH, Cosman D, Sims J, Lupton S, Acres B, Reed SG (1989) Recombinant interleukin 7, pre-B cell growth factor, has costimulatory activity on purified mature T cells. J Exp Med 169:707–716

    Article  PubMed  CAS  Google Scholar 

  144. Mufti GJ, Hamblin TJ, Clein CP (1983) Coexistent myelodysplasia and plasma cell neoplasia. Br J Haematol 54:91

    Article  PubMed  CAS  Google Scholar 

  145. Mufti GI, Stevens JR, Oscier DG et al (1985) Myelodysplastic syndromes: a scoring system with prognostic significance. Br J Haematol 59:425

    Article  PubMed  CAS  Google Scholar 

  146. Mufti GJ, Figes A, Hamblin TJ et al (1986) Immunological abnormalities in myelodysplastic syndromes: II. Serum immunglobulins and autoantibodies. Br J Haematol 63:143

    Article  PubMed  CAS  Google Scholar 

  147. Munker R, Gasson J, Ogawa M, Koeffler HP (1986) Recombinant human TNF induces production of granulocyte-monocyte colony-stimulating factor. Nature 323:79–82

    Article  Google Scholar 

  148. Nagasawa T, Abe T, Nakagawa T (1981) Pure red cell aplasia and hypogammaglobulinemia associated with T-cell chronic lymphocytic leukemia. Blood 57:1025

    Google Scholar 

  149. Najean Y, Pecking A (1979) Prognostic factors in acquired aplastic anemia: A study of 352 cases. Am J Med 67:564–571

    Article  PubMed  CAS  Google Scholar 

  150. Najean Y, Haguenauer O et al. (1990) Long-term (5 to 20 years) evolution of nongrafted aplastic anemia. Blood 76:2222–2228

    PubMed  CAS  Google Scholar 

  151. Nakahata T, Ogawa M (1982) Identification in culture of a class of hemopoietic colony-forming units with extensive capability to self-renew and generate multipotential hemopoietic colonies. Proc Natl Acad Sci USA 79:3843–3847

    Article  PubMed  CAS  Google Scholar 

  152. Nakahata T, Gross AJ, Ogawa M (1982) A stochastic model of self-renewal and commitment to differentiation of the primitive hemopoietic stem cells in culture. J Cell Physiol 113:455–458

    Article  PubMed  CAS  Google Scholar 

  153. Namen AE, Lupton S, Hjerrild K, Wignall J, Mochizuki DY, Schmierer A, Mosley B, March CJ, Urdal D, Gillis S (1988a) Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature 333:571–573

    Article  PubMed  CAS  Google Scholar 

  154. Namen AE, Schmierer AE, March CJ, Overell RW, Park LS, Urdal DL, Mochizuki DY (1988b) B cell precursor growth-promoting activity. Purification and characterization of a growth factor active on lymphocyte precursors. J Exp Med 167:988--1002

    Article  PubMed  CAS  Google Scholar 

  155. Nathan DG, Chess L, Hilman OG, Clark B, Howman DE (1978) Erythroid precursors in congenital hypoplastic (Diamond Blackfan) anemia. J Clin Invest 61:489

    Article  PubMed  CAS  Google Scholar 

  156. Ogawa M, Porter PN, Nakahata T (1983) Renewal and commitment to differentiation of hemopoietic stem cells (an interpretive review). Blood 61:823–829

    PubMed  CAS  Google Scholar 

  157. Ohno Y, Rege AB, Fishe JW, Barona J (1978) Inhibition of erythroid colony forming cells (CFU-E and BFU-E) in sera of azotemic patients with anemia of renal disease. J Lab Clin Invest 92:916

    CAS  Google Scholar 

  158. Otsuka T, Miyajima A, Brown N, Otsu K, Abrams J, Saeland S, Caux C, De Waal Malefijt R, De Vries J, Meyerson P (1988) Isolation and characterization of an expressible cDNA encoding human IL-3. J Immunol 140:2288

    PubMed  CAS  Google Scholar 

  159. Partanen S, Juvonen E, Ruutu T (1986) In vitro culture of haematopoietic progenitors in myelodysplastic syndromes. Scand J Haematol 36, Suppl 45: 98

    CAS  Google Scholar 

  160. Pasanen A, Tenuken R (1986) Haem synthesis in sideroblastic anaemias. Scand J Haematol 36 Suppl 45:60

    CAS  Google Scholar 

  161. Pasanen A, Vuopio P, Borgstroem GH, Tenuken R (1981) Haem biosynthesis in refractory sideroblastic anaemia associated with the preleukemic syndrome. Scand J Haematol27:35

    Google Scholar 

  162. Pasquali F, Bernasconi P, Casalone R et al (1982) Pathogenetic significance of „pure“ monosomy 7 in myeloproliferative disorders. Analysis of 14 cases. Human Genet 62:40

    Article  CAS  Google Scholar 

  163. Paul WE, Ohara J (1987) B cell stimulatory factor-l/IL-4. Ann Rev Immunol 5:429–460

    Article  CAS  Google Scholar 

  164. Pedersen-Bjergaard J, Larsen SO (1982) Indcidence of acute non lymphocytic leukemia, preleukemia and acute myeloproliferative syndrome up to 10 years after treatment of Hodgkin’s disease. N Engl J Med 307:965

    Article  PubMed  CAS  Google Scholar 

  165. Pedersen-Bjergaard J, Philip p, Larsen SO et al. (1990) Chromosome aberrations and prognostic factors in therapy-related myelodysplasia and acute non lymphocytic leukemia. Blood 76: 1083–1091

    Google Scholar 

  166. Peschel C, Marmont AM, Marone G et al. (1975) Pure red cell aplasia: Studies on an IgG serum inhibitor neutralizing erythropoietin. Brit J Haematol 30:411

    Article  Google Scholar 

  167. Peschel C, Paul WE, Ohara J, Green I (1987) Effects of B cell stimulating factor l/interieukin 4 on hematopoietic progenitor cells. Blood 70:254–263

    PubMed  CAS  Google Scholar 

  168. Pedersen-Bjergaard J, Nissen NJ, Sorensen HM et al (1980) Acute non-lymphocytic leukemia in patients with ovarian carcinoma following long-term treatment with treosulfan (= dihydroxybusulfan). Cancer 45:19–29

    Article  PubMed  CAS  Google Scholar 

  169. Philip R, Epstein LB (1986) Tumor necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, gamma-interferon and interleukin-1. Nature 323:86–89

    Article  PubMed  CAS  Google Scholar 

  170. Picot C, Triadou P, LaCombe C (1984) Relapsing pure red cell aplasia during pregnancy. N Engl J Med 311: 196

    PubMed  CAS  Google Scholar 

  171. Prchal JT, Trockmorton DW, Carroll DW (1978) A common progenitor for human myeloid and lymphoid cells. Nature 274:590

    Article  PubMed  CAS  Google Scholar 

  172. Purtilo DT, Zelkowitz L, Harada S, Brooks CS, Bechtold T, Lepscomb H, Yetz J, Rogers G (1984) Delayed onset of infectious mononucleosis associated with acquired agammaglobulinemia and red cell aplasia. Ann Int Med 101: 180

    PubMed  CAS  Google Scholar 

  173. Raskind WH, Tirumali N, Jacobson R et al (1984) Evidence for a multistep pathogenesis of a myelodysplastic syndrome. Blood 63: 1318

    PubMed  CAS  Google Scholar 

  174. Raz J, Pollack A (1984) Coexistence of myelomonocytic leukemia and monoclonal gammopathy or myeloma. Cancer 53: 83

    Article  PubMed  CAS  Google Scholar 

  175. Rennick D, Yang G, Gemmell L, Lee F (1987) Control of hemopoiesis by a bone marrow stromal cell clone: lipopolysaccharide- and interleukin-1-inducible production of colony-stimulating factors. Blood 69:682–691

    PubMed  CAS  Google Scholar 

  176. Resegotti L, DolCi C, Palestro G, Peschle C (1978) Paraproteinemic variety of pure red cell aplasia. Acta Haematol 60:227–232

    Article  PubMed  CAS  Google Scholar 

  177. Ribera JM, Cervantes F, Rozman C (1987) A multivariant analysis of prognostic factors in CMML according to the FAB criteria. Br J Haematol 65:307

    Article  PubMed  CAS  Google Scholar 

  178. Ricard MF, Sigank F, Imbert M, Sultan C (1979) Complementary investigation in myelodysplastic syndromes. In: Schmalzl F, Hellriegel KP (eds) Preleukemia. Springer Berlin Heidelberg New York p 56

    Google Scholar 

  179. Ricketts C, Cavill J, Napier JA, Jacobs A (1977) Ferrokinetics and erythropoiesis in man: an evaluation of ferrokinetic measurement. Br J Haematol 35:41

    Article  PubMed  CAS  Google Scholar 

  180. Rosner F, Grunewald HW (1980) Cytotoxic drugs and leukaemogenesis. Clinics in Haematol 9:663

    CAS  Google Scholar 

  181. Rosner F, Carey RW, Zarrabi MH (1978) Breast cancer and acute leukemia: report of 24 cases and review of the literature. Am J Hematol 4: 151

    Article  PubMed  CAS  Google Scholar 

  182. Ruiz-Arguelles GJ (1987) Immunologic classification of blast cells in RAEB. Br J Haematol 65: 124

    Article  PubMed  CAS  Google Scholar 

  183. Ruutu P (1986) Granulocyte function in myelodysplastic syndromes. Scand J Haematol36, Suppl 45:66

    CAS  Google Scholar 

  184. Sanderson CJ, Campbell HJ, Young IG (1988) Molecular and cellular biology of eosinophil differentiation factor (interleukin 5) and its effects on B cells in man and mouse. Immunol Rev 102:29

    Article  PubMed  CAS  Google Scholar 

  185. Santoli D, Clark SC, Kreider BL, Maslin PA, Rovera G (1988) Amplification of IL- 2 driven T cell proliferation by recombinant human IL-3 and granulocyte-macrophage colony-stimulating factor. J Immunol 141:519

    PubMed  CAS  Google Scholar 

  186. Schindler D, Kubbies M, Hoehn H, Schinzel A, Rabinovitch PS (1985) Presymptomatic diagnosis of Fanconi’s anemia. Lancet 1:937

    Google Scholar 

  187. Schmalz I F, Konwalinka G, Michlmayr G et al (1978) Detection of cytochemical and morphological anomalies in ’Preleukemia’ Acta haemat 59: 1

    Google Scholar 

  188. SchrOder TM, Stahl-Mauge C (1979) Mutagenic effects of isonicotinic acid hydrazide in Fanconis anemia. Hum Genet 52:309

    Article  Google Scholar 

  189. Schröder TM, Tilgen D, Kruge J, Vogel F (1976) Formal genetics of Fanconi’s anemia. Hum Genet 32:257

    Article  Google Scholar 

  190. Seigneurin D, Audhuy B (1983) Auer rods in refractory anemia with excess of blasts: presence and significance. Am 1 Clin Pathol 80:359

    CAS  Google Scholar 

  191. Sherr CJ, Rettenmier CW, Sacca R, Roussel MF, Look AT, Stanley ER (1985) The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor CSF-1. Cell 41:665

    Article  PubMed  CAS  Google Scholar 

  192. Sieff CA, Emerson SG, Donahue RE, Nathan DG, Wang EA, Wong GG, Clark SC (1985) Human recombinant granulocyte-macrophage colony-stimulating factor: A multiline age hematopoietin. Science 230: 1171–1173

    Article  PubMed  CAS  Google Scholar 

  193. Sirinavin C, Trowbridge AA (1975) Dyskeratosis congenita: Clinical features and genetic aspects. Report of a family and review of the literature. J Med Genet 12:339

    Article  PubMed  CAS  Google Scholar 

  194. Smith D, Tribble TJ, Yeager AS (1978) Spontaneous resolution of severe aplastic anemia associated with viral hepatitis A in a 6-year-old child. Am J Hematol 5:247–252

    Article  PubMed  CAS  Google Scholar 

  195. Socinski MA, Ershler WB, Tosato G, Blass RM (1984) Pure red cell aplasia associated with chronic Epstein-Barr virus infection: Evidence for T cell-mediated suppression of erythroid colony forming units. J Lab clin Med 104:995

    PubMed  CAS  Google Scholar 

  196. Sokal G, Michaux JL, Van den Berghe H et al (1975) A new hematologic syndrome with a distinct karyotype: The 5q-chromosome. Blood 46:519

    PubMed  CAS  Google Scholar 

  197. Solal-Celigny P, Desaint B, Herrera A (1984) Chronic myelomonocytic leukaemia according to FAB classification: Analysis of 35 cases. Blood 63:634

    PubMed  CAS  Google Scholar 

  198. Speck B, Gratwohl A, Niesen C, Osterwalder B, Würsch A, Tichelli A, Lori A, Reusser P, leannet M, Signer E (1986) Treatment of severe aplastic anemia. Exp Haematol 14: 126–132

    CAS  Google Scholar 

  199. Spitzer G, Verma D, Dicke K (1979) Subgroups of oligoleukemia as identified by in vitro agar culture Leuk Res 3:29

    CAS  Google Scholar 

  200. Spivac JL, Smith RRL, Ihle JN (1985) Interleukin 3 promotes the in vitro proliferation of murine pluripotent hematopoietic stem cells. J Clin Invest 76: 1613

    Article  Google Scholar 

  201. Stanley ER, Heard PM (1977) Factors regulating macrophage production and growth: purification and some properties of the colony stimulating factor from medium conditioned by mouse L cells. J BioI Chern 252:4305

    CAS  Google Scholar 

  202. Stephenson JR, Axelrad AA, McLeod DL, Shreeve MM (1971) Induction of colonies of hemoglobin-synthesizing cells by erythropoietin in vitro. Proc Natl Acad Sci USA 68:1542

    Article  PubMed  CAS  Google Scholar 

  203. Storb R, Thomas ED, Weiden PL et al. (1976) Aplastic anemia treated by allogeneic bone marrow transplantation: a report on 49 new cases from Seattle. Blood 43:817

    Google Scholar 

  204. Streeter RR, Presant CA, Reinhard E (1977) Prognostic significance of thrombocytosis in idiopathic sideroblastic anemia. Blood 50:427

    PubMed  CAS  Google Scholar 

  205. Suda T, Suda J, Ogawa M, Ihle JN (1985) Permissive role of interleukin 3 (IL-3) in proliferation and differentiation of multipotential hemopoietic progenitors in culture. J Cell Physiol 124: 182–190

    Article  PubMed  CAS  Google Scholar 

  206. Suda J, Suda T, Kubota K, Ihle IN, Saito M, Miura Y (1986) Purified interleukin 3 and erythropoietin support the terminal differentiation of hemopoietic precursors in serum-free culture. Blood 67:1002

    PubMed  CAS  Google Scholar 

  207. Tadmori W, Feingersh D, Clark SC, Choi YS (1989) Human recombinat IL-3 stimulates B cell differentiation. J Immunol 142: 1950–1955

    PubMed  CAS  Google Scholar 

  208. Takagi S, Kitagawa S, Takeda A et al (1984) Natural killer-interferon system in patients with preleukemic states. Br J. Haematol 58:71

    Article  PubMed  CAS  Google Scholar 

  209. Tichelli A, Gratwohl A, Würsch A, Nissen C, Speck G (1988) Secondary leukemia after severe aplastic anemia. Blut 56:79–81

    Article  PubMed  CAS  Google Scholar 

  210. Tichelli A, Gratwohl A, Wursch A, Nissen C, Speck B (1988) Late hematological complications in severe aplastic anemia. Br J Haematol 69:413

    Article  PubMed  CAS  Google Scholar 

  211. Till JE, McCulloch EA (1961) A direct measurement of the radiation sensitivity of normal bone marrow cells. Radiat Res 14:213

    Article  PubMed  CAS  Google Scholar 

  212. Tinegate H, Gaunt L, Hamilton PJ (1983) The 5q-syndrome: an underdiagnosed form of macrocytic anaemia. Br J Haematol 54:103

    Article  PubMed  CAS  Google Scholar 

  213. Todd WM, Pierre RV (1986) Preleukemia: A longterm prospective study of 326 patiens. Scand J Haematol 36, Suppl 45: 114

    CAS  Google Scholar 

  214. Tricot G, De Wolf-Peeters C, Vlietnick R (1984) Bone marrow histology in myelodysplastic syndromes. Br J Haematol 58:217

    Article  PubMed  CAS  Google Scholar 

  215. Tricot G, Vlietnick R, Boogaerts MA et al (1985) Prognostic factors in the myelodysplastic syndromes: importance of initial data on peripheral blood counts, bone marrow cytology, trephine biopsy and chromosomal analysis. Br J Haematol 60:659–670

    Article  Google Scholar 

  216. Tricot G, Mecucci C, Van den Berghe H (1986) Evolution of the myelodysplastic syndromes. Br J Haematol 63:609

    Article  PubMed  CAS  Google Scholar 

  217. Van Damme J, Opdenakker G, Simpson RJ, Rubira MR, Cayphas S, Vink A, Billiau A, Van Snick J (1987) Identification of the human 26 kD protein, interferon β2(IFN-β2), as a B cell hybridoma/plasmocytoma growth factor induced by interleukin 1 and tumor necrosis factor. J Exp Med 165:914

    Article  PubMed  Google Scholar 

  218. Van den Berghe H Vermaelen K, Mecucci et al (1985) The 5q-anomaly, Cancer Gen Cytogen 17: 189

    Google Scholar 

  219. Van den Berghe H (1987) Cytogenetics. In: Leukemia, Whittaker JA, Delamore IW (eds.) Blackwell scientific Publications, p 137

    Google Scholar 

  220. van Leeuwen BH, Martinson ME, Webb GC, Young IG (1989) Molecular organization of the cytokine gene cluster, involving the human IL-3, IL-4, IL-5, and GMCSF genes, on chromosome 5. Blood 73:1142–1148

    PubMed  Google Scholar 

  221. Varela BL, Chuang C, Woll JE, Bennett JM (1985) Modifications in the classification of primary myeloproliferative syndromes: the addition of a scoring system. Haematol Oncol 3:55

    Article  CAS  Google Scholar 

  222. Verma DS, Spitzer G, Dicker KA et al (1979) In vitro agar culture patterns in preleukemia and their clinical significance. Leuk Res 3:29

    Article  PubMed  Google Scholar 

  223. Verwilghen R, Reybrouck G, Gallens L, Cosemans J (1965) Antituberculous drugs and sideroblastic anaemia. Br J Haematol 11:92

    Article  PubMed  CAS  Google Scholar 

  224. Wang WC, Mentze WC (1976) Differentiation of transient erythroblastopenia of childhood from congenital hypoplastic anemia. J Pediatr 88:784

    Article  PubMed  CAS  Google Scholar 

  225. Weisdorf DJ, Oken MM, Johnson GJ et al (1981) Auer rod positive dysmyelopoieticsyndrome. Am J Hematol 11:397

    Article  PubMed  CAS  Google Scholar 

  226. Weisdorf DJ, Oken MM, Johnson GJ (1983) Chronic myelodysplastic syndrome: Short survival with or without evolution of acute leukemia. Br J Haematol55:691

    Google Scholar 

  227. Whitehouse JMA (1985) Risk of leukaemia associated with cancer chemotherapy. Brit Med 1 290:261

    Article  Google Scholar 

  228. Williams DM (1973) Drug-induced aplastic anemia. Semin Hematol 10: 195

    PubMed  CAS  Google Scholar 

  229. Wong GG, Witek-Giannotti JS, Temple PA et al. (1988) Stimulation of murine hemopoietic colony formation by human IL-6. J Immunol 140:3040

    PubMed  CAS  Google Scholar 

  230. Worsley A, Oscier DG, Stevens J et al (1988) Prognostic features in CMML: a modified Bournemonth score gives the best prediction of survival. Br J Haematol 68:17

    Article  PubMed  CAS  Google Scholar 

  231. Yoshida Y, Oguma S, Uchino H, Maekawa T (1987) Significance of ring sideroblasts in RAEB. Br J HaematoI65:119

    Google Scholar 

  232. Young N, Mortimer P (1984) Viruses and bone marrow failure. Blood 63:729–737

    PubMed  CAS  Google Scholar 

  233. Young NS, Mortimer PP, More JG, Humphries K (1984) Characterization of a virus that causes transient aplastic crisis. J Clin Invest 73:224–230

    Article  PubMed  CAS  Google Scholar 

  234. Young N (1988) Hematologic and Hematopoietic Consequences of B19 Parvovirus Infection. Semin Hematol 25:159–172

    PubMed  CAS  Google Scholar 

  235. Zeldis JB, Dienstag JL, Gale RP (1983) Aplastic anemia and non-A, non-B hepatitis. Am J Med 74:64–68

    Article  PubMed  CAS  Google Scholar 

  236. Zeok JV, Todd EP, Dillon M, Desimore P, Utlely JR (1978) Role of thymectomy in red cell aplasia. Ann Thorac Surg 28:257

    Article  Google Scholar 

  237. Zittoun R (1976) Subacute and chronic myelomonocytic leukaemia: A distinct haematological entity. Br J Haematol 32:1

    Article  PubMed  CAS  Google Scholar 

  238. Zoumbos NC, Gascon P, Djeu JY, Trost SR, Young NS (1985) Circulating activated suppressor T lymphocytes in aplastic anemia. N Engl 1 Med 312:257–265

    Article  CAS  Google Scholar 

  239. Zsebo KM, Wypych J, Yuschenkoff VN, Lu H, Hunt P, Dukes PP, Langley KE (1988) Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow. Blood 71: 962–968

    PubMed  CAS  Google Scholar 

  240. Zucali IR, Broxmeyer H, Gross MA, Dinarello CA (1988) Recombinant human tumor necrosis factors alpha and beta stimulate fibroblasts to produce hemopoietic growth factors in vitro. J Immunol 140:840–844

    PubMed  CAS  Google Scholar 

  241. 2nd International Workshop: Cancer Genetics (1982) Cancer Genet Cytogenet 5:265

    Google Scholar 

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  1. H. Huber
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  1. Abteilung für Hämatologie und Onkologie, Universitätsklinik für Innere Medizin, Anichstraße 35, A-6020, Innsbruck, Austria

    Heinz Huber

  2. II. Med. Universitätsklinik und Poliklinik, Chemnitzstraße 33, D-2300, Kiel 1, Germany

    Helmut Löffler

  3. Universitätsklinik für Innere Medizin, Anichstraße 35, A-6020, Austria, Österreich

    Dorothea Pastner

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Huber, H., Peschel, C., Zwierzina, H., Nachbaur, D., Pastner, D. (1992). Differentialdiagnose der primären Knochenmarkinsuffizienz. In: Huber, H., Löffler, H., Pastner, D. (eds) Diagnostische Hämatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76860-6_4

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