Modulierende Regulation von Hormoneffekten bei muskulärer Aktivität

  • A. Viru
  • K. Toode


Da hormonale Effekte sowohl auf der Ebene der Produktion und Sekretion der Signalmoleküle wie auch auf der Ebene deren Bindung reguliert werden, müssen konsequenterweise Veränderungen auf beiden Ebenen in Betracht gezogen werden, wenn es um die Frage geht, inwieweit Hormone an der Stoffwechselkontrolle unter verschiedenen Situationen und Aktivitäten beteiligt sind.


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  1. 1.
    Askew EW, Dohm GL, Huston RL, Sneed TW, Daidy EP (1972) Response of rat tissue lipolysis to physical training and exercise. Proc Soc Exp Biol Med 141:123–129PubMedGoogle Scholar
  2. 2.
    Askew EW, Hecker AL, Coppes VG, Stifel FB (1978) Cyclic AMP metabolism in adipose tissue of exercise-trained rats. J Lipid Res 19:729–736PubMedGoogle Scholar
  3. 3.
    Bieger W, Zittel R, Zappe H, Weicker H (1983) Einfluß körperlicher Aktivität auf die Katecholaminrezeptor-Regulation. In: Heck H, Hollmann W, Liesen H, Rost R (Hrsg) Sport: Leistung und Gesundheit. Deutscher Ärzte Verlag, Köln. S 271–275Google Scholar
  4. 4.
    Björntorp P, deJounge K, Sjöstrand L, Sullivan L (1970) The effect of physical training on insulin production in obesity. Metabolism 19:631–639PubMedCrossRefGoogle Scholar
  5. 5.
    Bönen A, Tan MH, Clune P, Kirby RL (1985) Effects of exercise on insulin binding to human muscle. Am J Physiol 248:E403-E408PubMedGoogle Scholar
  6. 6.
    Bukowiecki L, Lupien J, Follea N, Paradis A, Richard D, LeBlanc J (1980) Mechanism of enhanced lipolysis in adipose tissue of exercise-trained rats. Am J Physiol 239:E422-E429PubMedGoogle Scholar
  7. 7.
    Butler J, O’Brien M, O’Malley K, Kelly JG (1982) Relationship of ß-adrenoreceptor density to fitness in athletes. Nature 198:60–62CrossRefGoogle Scholar
  8. 8.
    Chapler CK (1971) Effects of propranolol and epinephrine infusion on glycolysis in dog skeletal muscle in situ. Can J Physiol Pharmacol 50:471–475CrossRefGoogle Scholar
  9. 9.
    Craig BW, Hammons GT, Gartwaite SM, Jarett L, Holloszy JO (1981) Adaptation of fat cells to exercise: response of glucose uptake and oxidation to insulin. J Appl Physiol 51:1500–1506PubMedGoogle Scholar
  10. 10.
    Davies AO (1988) Exercise-induced fall in couplin of human ß2~adrenergic receptors. Metabolism 37:916–918PubMedCrossRefGoogle Scholar
  11. 11.
    Despres JP, Bouchard C, Savard R, Tremblay A, Marcotte M, Theriault G (1984) Effects of exercise-training and detraining on fat cell lipolysis in men and women. Eur J Appl Physiol 53:25–30CrossRefGoogle Scholar
  12. 12.
    Dickhuth HH, Theissen M, Lehmann M, Auch-Schwelk W, Keul J (1987) Sensitivity of the physiologically hypertrophied heart to isoproterenol. Int J Sports Med 8:392–396PubMedCrossRefGoogle Scholar
  13. 13.
    Dohm GL, Sinha MK, Caro JF (1987) Insulin receptor binding and protein kinase activity in muscels of trained rats. Am J Physiol 252:E170-E175PubMedGoogle Scholar
  14. 14.
    Dowell RT, Tipton CM (1980) Influence of training on the heart rate of rats of isoproterenol and propranolol. Physiologist 13:182Google Scholar
  15. 15.
    Elks ML, Manganiello VC (1985) Antilipolytic action of insulin. Role of cAMP phosphodiesterase activation. Endocrinology 116:2121CrossRefGoogle Scholar
  16. 16.
    Eller A, Nyskas C, Szabo G, Endröczi E (1981) Corticosterone binding in myocardial tissue of rats after chronic stress and adrenalectomy. Acta Physiol Acad Sci Hung 53:205–211Google Scholar
  17. 17.
    Espinal J, Dohm GL, Nesholme ED (1983) Sensitivity to insulin of glycolysis and glycogen synthesis of isolated soleus-muscle strips from sedentary exercised and exercise-trained rats. Biochem J 212:453–458PubMedGoogle Scholar
  18. 18.
    Evans JM, Funk JN, Charles JB, Randall DC, Known CF (1988) Endurance training in dogs increases vascular responsiveness to an aj-agonist. J Appl Physiol 65:625–632PubMedGoogle Scholar
  19. 19.
    Feldkoren BJ (1979) The effect of retabolil and training on synthesis of ribosomal RNA in skeletal muscle. In: Rogozkin V, Litvinova V, Hanina J (eds) Medicine and sport. Leningrad, pp 124–130Google Scholar
  20. 20.
    Feldkoren BJ, Kosedut TV (1981) Effect of anabolic steroids on content of corticosterone in adrenals during systematic physical exercise. Acta Commet Univ Tartuensis 562:114–121Google Scholar
  21. 21.
    Frenkl R, Csálay, Scákváry G, Lángfy G (1970) Untersuchung der ACTH-Wirkung auf den Steroidspiegel des Plasmas im trainierten und im untrainierten Organismus. Med Sport 10:122–124Google Scholar
  22. 22.
    Frenkl R, Csälay L (1962) The effect of regular muscular activity on adrenocortical function in rats. J Sports Med Phys Fitness 2:207–211PubMedGoogle Scholar
  23. 23.
    Frenkl R, Csälay L, Skäkväry G (1975) Further experimental results concerning the relationship of muscular exercise and adrenal function. Endokrinologie 66:285–291PubMedGoogle Scholar
  24. 24.
    Freud BJ, Claybaugh JR, Dice MS, Mashiro GM (1987) Hormonal and vascular fluid responses to maximal exercise in trained and untrained males. J Appl Physiol 63:669–675Google Scholar
  25. 25.
    Friedman DB, Ordway GA, Williams RS (1987) Exercise-induced functional desensitization of canine cardial β-adrenergic receptors. J Appl Physiol 62:1721–1723PubMedGoogle Scholar
  26. 26.
    Hickson RC, Davis JR (1981) Partial prevention of glucocorticoid-induced muscle atrophy by endurance training. Am J Physiol 214:E226-E232Google Scholar
  27. 27.
    Hickson RC, Galassi TM, Kurowski TT, Daniels DG, Chatterton RT (1984) Androgen and glucocorticoid mechanism in exercise-induced cardiac hypertrophy. Am J Physiol 246:H761-H767PubMedGoogle Scholar
  28. 28.
    Hughson RL, Sutton JR, Fitzgerald JD, Jones NL (1976) Reduction of intrinsic sinoatrial frequences and norepinephrine response to exercised rat. Can J Physiol Pharmacol 55:813–820CrossRefGoogle Scholar
  29. 29.
    Ivy JL, Sherman WM, Miller W, Farrell S, Frishberg B (1983) Glycogen synthesis: effect of diet and training. In: Knuttgen HG, Vogel JA, Poortmans J (eds) Biochemistry of exercise. Human Kinetics, Champaign, pp 291–296Google Scholar
  30. 30.
    James DE, Burleich KM, Kraegen EW, Chisholm DJ (1983) Effect of acute exercise and prolonged training on insulin response to intravenous glucose in vivo rat. J Appl Physiol 55:1660–1664PubMedGoogle Scholar
  31. 31.
    Johansen K, Munsk O (1979) The relationship between maximal oxygen uptake and glucose tolerance/insulin response ratio in normal young men. Horm Metab Res 11:424–427PubMedCrossRefGoogle Scholar
  32. 32.
    Jost J, Weiß M, Weicker H (1989) Comparison of sympatho-adrenergic regulation at rest and of the adrenoceptor system in swimmers, long-distance runner, weight-lifters, wrestlers, und untrained men. Eur J Appl Physiol 58:596–604CrossRefGoogle Scholar
  33. 33.
    Kalinski MJ, Zemtsova II, Kurski MP, Ossipenko AA (1980) Action of training and exercise on 3’, 5’ AMP content and activity of enzymes of its metabolism in rat muscles. Uks Biokhin Zh 52:611–616Google Scholar
  34. 34.
    Kalinski MJ, Kurski MP, Zemsova II, Ossipenki AA (1981) Alterations of some properties of cAMP-dependent proteinkinases of skeletal muscles in training with physical exercises. Biokhimüa 46:120–125Google Scholar
  35. 35.
    Kemmer FW, Berger M, Herberg L, Gries FD (1977) Effects of physical training on glucose tolerance and on glucose metabolism of isolated muscle in normal rats. Diabetologia 13:407Google Scholar
  36. 36.
    Kjaer M, Mikenes KJ, Christensen NJ et al. (1984) Glucose turnover and hormonal changes during insulin-induced hypoglycemia in trained humans. J Appl Physiol 57:21–27PubMedGoogle Scholar
  37. 37.
    Koivisto VA, Akeblom HK, Nikkilä EA (1976) Carbohydrate and lipid metabolism during exercise in experimental diabetes. Acta Endocrinol [Suppl. 203] 32:3–4Google Scholar
  38. 38.
    Koivisto VA, Sanan V, Conrad P, Hendler R, Nadel E, Fehlig P (1979) Insulin binding to monocytes in trained athletes. J Clin Invest 64:1011–1019PubMedCrossRefGoogle Scholar
  39. 39.
    Koivisto VA, Sanan V, Fehlig P (1980) Effects of acute exercise on insulin binding to monocytes in obesity. Metabolism 29:168–172PubMedCrossRefGoogle Scholar
  40. 40.
    Koivisto VA, Yiki-Järvinen H (1987) Effect of exercise on insulin binding and glucose transport in adipocytes of normal humans. J Apple Physiol 63:1319–1323Google Scholar
  41. 41.
    Korge P, Mediainen L (1986) The effect of isoprenaline and physical exercise to exhaution on the mechanism of glucocorticoid action in the rat heart. J Mol Cell Cardiol 18:557–586PubMedCrossRefGoogle Scholar
  42. 42.
    Kurowski TT, Chatterton RT, Hickson RS (1984) Glucocorticoid-induced cardiohy-pertrophy additive effects of exercise. J Appl Physiol 57:524-?Google Scholar
  43. 43.
    Kurskij MD; Ossipenko AA, Kalinski MI, Kondratjuk TP (1978) Some properties of rat skeletal muscle adenosine 3’, 5’-monophosphate-dependent protein kinase at normal state and after long-term physical loading up to fatigue. Biokhimiia 43:1176–1182Google Scholar
  44. 44.
    Lamberts SW, Timmermans HA, Kramer-Blankenstijn M, Birkenjäger JC (1975) The mechanism of potentiating effect of glucocorticoids on catecholamine-induced lipolysis. Metabolism 24:681–689PubMedCrossRefGoogle Scholar
  45. 45.
    Landmann R, Portenier M, Staehelin M, Wesp M, Box R (1988) Changes in β-adrenoceptors and leucocyte subpopulations after physical exercise in normal subjects. Naunyn Schmiedegergs Arch Pharmacol 337:261–266Google Scholar
  46. 46.
    LeBlanc J, Boulay M, Dulac S, Jobin M, Labrie A, Rousseau-Migneron S (1977) Metabolic and cardiovascular responses to norepinephrine in trained and nontrained human subjects. J Appl Physiol 42:166–173PubMedGoogle Scholar
  47. 47.
    LeBlanc J, Nadeau A, boulay M, Rousseau-Migneron S (1979) Effect of physical training and adiposity on glucose metabolism and 125J-insulin-binding. J Appl Physiol 46:235–239PubMedGoogle Scholar
  48. 48.
    Lehmann M, Keul J, DaPrada M (1981) Plasma catecholamines in trained and untrained volunteers during graduated exercises. Int J Sports Med 2:143–147PubMedCrossRefGoogle Scholar
  49. 49.
    Lehmann M, Dickhuth HH, Schmid P, Porzig H, Keul J (1984) Plasma catecholamines, β-adrenergic receptors, and isoproterenol sensitivity in endurance trained and nonendurance trained volunteers. Eur J Appl Physiol 52:362–369CrossRefGoogle Scholar
  50. 50.
    Lehmann M, Hasler K, Bergdolt E, Keul J (1986) α2-adrenoreceptor density on intact platelets and adrenaline-induced platelets aggregation in endurance and nonendurance trained subjects. Int J Sports Med 7:172–176PubMedCrossRefGoogle Scholar
  51. 51.
    McMannus BM, Lamb DR, Judis JJ, Scala J (1975) Skeletal muscle leucine incorporation and testosterone uptake in exercised guinea pigs. Eur J Appl Physiol 34:149–156CrossRefGoogle Scholar
  52. 52.
    Michel G, Vocke T, Fiehn W, Weicker H, Schwarz W, Bieger WP (1984) Bidirectional alteration of insulin receptor affinity by different forms of physical exercise. Am J Physiol 246:E156-E159Google Scholar
  53. 53.
    Michel G, Schwarz W, Bieger WP (1985) Exercise-induced regulation of insulin receptor affinity: Role of circulating metabolites. Int J Sports Med 6:100–106PubMedCrossRefGoogle Scholar
  54. 54.
    Mikenes KJ, Sonne B, Farrell PA, Tronier B, Galbo H (1988) Effect of physical exercise on sensitivity and responsiveness to insulin in humans. Am J Physiol 254:E248-E259Google Scholar
  55. 55.
    Mikenes KJ, Sonne B, Farrell PA, Tornier B, Galbo H (1989) Effect of training on the doseresponse relationship for insulin action in men. J Appl Physiol 66:695–703Google Scholar
  56. 56.
    Mondon CE, Doekas CB, Reaven GM (1980) Site of enhanced insulin sensivity in exercise trained rats at rest. Am J Physiol 239:E169-E177PubMedGoogle Scholar
  57. 57.
    Moore RL, Riedy M, Gollnick PD (1982) Effect of training on β-adrenergic receptor number in rat heart. J Appl Physiol 52:1133–1137PubMedGoogle Scholar
  58. 58.
    Niyazmukhammedov MB, Yakovlev NN (1976) Changes of 3’,-5’-AMP phosphodiesterase activity and inactivation of insulin during muscular activity. Sechenov Physiol J USSR 62:768–775Google Scholar
  59. 59.
    Oscai LB, Carsko RA, Wergeies AC, Palmer WK (1981) Exercise and the cAMP system in rat adipose tissue. I. Lipid mobilization. J Appl Physiol 50:250–254PubMedGoogle Scholar
  60. 60.
    Owens JL, Tuller EO, Nutter DO, Girolamo M (1977) Influence of moderate exercise on adipocyte metabolism and hormonal responsiveness. J Appl Physiol 43:425–43061.PubMedGoogle Scholar
  61. 61.
    Palmer WK (1988) Effect of exercise on cardiac cyclic AMP. Med Sci Sports Exerc 20:525–530PubMedGoogle Scholar
  62. 62.
    Pavlik G, Frenkl R (1975) Sensivity to catecholamines and histamine in the trained and in the untrained human organism an sensitivity changes during digestion. Eur J Appl Physiol 34:199–204CrossRefGoogle Scholar
  63. 63.
    Pavlik G, Hegyi A, Frenkl R (1976) Alpha and beta adrenergic sensitivity in trained and untrained albino rats. Eur J Appl Physiol 36:65–73CrossRefGoogle Scholar
  64. 64.
    Pederson O, Beck-Nielsen H, Heding L (1980) Increased insulin receptors after exercise in patients with insulin-dependent diabetes mellitus. N Engl J Med 302:886–892CrossRefGoogle Scholar
  65. 65.
    Pederson O, Bak J (1986) Effect of acute exercise and physical training on insulin receptor and insulin action. In: Saltin B (ed) Biochemistry of exercise VI. Champaign (Human Kinetics Publ, pp 87–94)Google Scholar
  66. 66.
    Richter EA, Garetto LP, Goodman MN, Ruderman NB (1982) Muscle metabolism following exercise in rat. Increased sensitivity to insulin. J Clin Invest 69:785–793PubMedCrossRefGoogle Scholar
  67. 67.
    Sato Y, Hayamizu S, Yamamoto C, Okhuwa Y, Yamanouchi K, Sakamoto N (1986) Improved insulin sensitivity in carbohydrate and lipid metabolism after physical training. Int J Sports Med 7:307–310PubMedCrossRefGoogle Scholar
  68. 68.
    Savard R, Despres JP, Deshaies Y, Marcotte M, Bouchard C (1985) Adipose tissue lipid accumulation pathways in marathon runners. Int J Sports Med 6:287–291PubMedCrossRefGoogle Scholar
  69. 69.
    Savard R, Despres JP, Marcotte M, Theriault G, Tremblay A, Bouchard C (1987) Acute effects of endurance exercise on human adipose tissue metabolism. Metabolism 36:480–485PubMedCrossRefGoogle Scholar
  70. 70.
    Seene T, Viru A (1982) The catabolic effect of glucocorticoids on different types of skeletal muscle fibers and its dependence upon muscle activity and interaction with anabolic steroids. J Steroid Biochem 16:349PubMedCrossRefGoogle Scholar
  71. 71.
    Shephard RE, Semberowich WL, Green HE, Gollnick PD (1977) Effect of physical training on control mechanism of lipolysis in rat fat cell ghosts. J Appl Physiol 42:884–888Google Scholar
  72. 72.
    Shephard RE, Noble EG, Klug GA, Gollnick PD (1981) Lipolysis and cAMP accumulation in adipocytes in response to physical training. J Appl Physiol 50:143–148Google Scholar
  73. 73.
    Siltovkori A, Tirri R, Harri MNE (1977) Alpha-receptor subsensitivity of isolated atria from rats following physical training or repeated ACTH-injections. Acta Physiol Scand 99:457–461CrossRefGoogle Scholar
  74. 74.
    Soman VR, Koivisto VA, Grantham P, Felig P (1978) Increased insulin binding to monocytes after exercise in normal man. J Clin Endocrinol 47:216–218CrossRefGoogle Scholar
  75. 75.
    Soman VR, Koivisto VA, Deibert D, Felig P, DeFronzo RA (1979) Increased insulin sensitivity and insulin binding to monocytes after physical training. N Engl J Med 301:1200–1204PubMedCrossRefGoogle Scholar
  76. 76.
    Takeda N, Daniniak P, Turck D, Rupp H, Jacob R (1985) The influence of endurance training on catecholamines responsiveness, P-adrenoceptor density and myosin isoenzyme pattern of rat ventricular myocardium. Basic Res Cardiol 80:88–89PubMedCrossRefGoogle Scholar
  77. 77.
    Tchaikovski VS, Astratenkova IV, Basharina OB (1986) The effect of exercise on the content and reception of the steroid hormones in rat skeletal muscles. J Steroid Biochem 24:251–253CrossRefGoogle Scholar
  78. 78.
    Tharp GD, Buuck R (1974) Adrenal adaptation to chronic exercise. J Appl Physiol 37:720–722PubMedGoogle Scholar
  79. 79.
    Tremblay A, Despres JP, Bouchard C (1984) Adipose tissue characteristics of ex-obese long-distance runners. Int J Obes 8:641–648PubMedGoogle Scholar
  80. 80.
    Vinten J, Galbo H (1983) Effect of physical training on transport and metabolism of glucose in adipocytes. Am J Physiol 244:E129-E134PubMedGoogle Scholar
  81. 81.
    Vinten J, Norgaard-Petersen L, Sonne B, Galbo H (1985) Effects of physical training on glucose transporters in fat cell fractions. Biochim Biophys Acta 841:223–227PubMedGoogle Scholar
  82. 82.
    Viru A (in press) Adaptive regulation of hormone interaction with receptor. Exp Clin EndocrinolGoogle Scholar
  83. 83.
    Welster BA, Vigna SR, Paquette T (1986) Acute exercise, epinephrine and diabetes enhance insulin binding to skeletal muscle. Am J Physiol 250:E186-E197Google Scholar
  84. 84.
    Wirth A, Holm G, Nilsson B, Smith U, Bjorntrop P (1980) Insulin kinetics and insulin binding to adipocytes in physically trained and food-restrictive rats. Am J Physiol 238:E108-E115PubMedGoogle Scholar
  85. 85.
    Williams RS, Eden RS, Moll ME, Lester RM, Wallance AG (1981) Autonomic mechanism of training bradycardia: p-adrenergic receptors in humans. J Appl Physiol 51:1232–1237PubMedGoogle Scholar
  86. 86.
    Yakovlev NN (1975) The role of sympathic nervous system in the adaptation of skeletal muscles to increased activity. In: Howald H, Poortmans JR (eds) Metabolic adaptation to prolonged physical exercise. Birkhauser, Basel, pp 293–300Google Scholar
  87. 87.
    Yakovlev NN (1977) Changes of the organism sensitivity to adrenocorticotropin elicited by the adaptation to increased muscular activity. Sechenov Physiol J USSR 63:320–323Google Scholar
  88. 88.
    Zentsova II, Kalinski MI, Kurski MD, Ossipenko AA (1981) Action of termostabile protein inhibitor on activity of 3’, 5-AMP-dependent proteinkinase of skeletal muscle during training with prolonged physical exercises. Dokl Acad Sci USSR (Kiev) 5/2:72–75Google Scholar

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© Springer-Verlag Berlin Heidelberg 1991

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  • A. Viru
  • K. Toode

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