Parallels Between Renal Transplant Arteriopathy and Atherosclerosis in Respect of Functional Morphology

Part of the Current Topics in Pathology book series (CT PATHOLOGY, volume 87)


Despite greater standardization of surgical technique and considerable progress in the postoperative management of patients who have undergone allogeneic organ transplantation, we are increasingly faced with the problem of obliterative transplant arteriopathy, particularly after kidney transplantation. In addition to interstitial and glomerular reactions within the transplant, vascular, i.e. predominantly arterial, lesions present intriguing problems to the pathologist. Many facets of the pathogenesis of renal transplant arteriopathy (RTA) are still unexplained. Judging by macroscopic and histologic analysis of the cellular pattern, the morphology of transplanted vessels shows considerable similarities with the morphogenesis of atherosclerosis (Zollinger et al. 1978; Cerilli et al. 1987; Müeller-Hermelink and Dämmrich 1989; Roessner et al. 1989; Vollmer et al. 1991b).


Smooth Muscle Cell Renal Transplant Vascular Wall Foam Cell Human Atherosclerotic Plaque 
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