Neuropathological and Brain Imaging Studies in Positive and Negative Schizophrenia

  • A. Bogerts
  • P. Falkai
  • G. Degreef
  • J. A. Lieberman
Conference paper

Abstract

Recent interest in neuroanatomical schizophrenia research has focused on three major brain regions: (1) the limbic system with its important telencephalic components comprising the medial temporal lobe structures and the cingulate gyrus; (2) the prefrontal cortex, which roughly consists of frontal cortical areas anterior to the level of the genu of the corpus callosum; and (3) the basal ganglia, most importantly the globus pallidus.

Keywords

Zinc Migration Depression Dopamine Dementia 

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References

  1. Altshuler L, Conrad A, Kovelman JA, Scheibel A (1987) Hippocampal Pyramidal Cell Orientation in Schizophrenia. Arch Gen Psychiatry 44:1094–1098PubMedGoogle Scholar
  2. American Psychiatric Association (1980) DSM-III: diagnostic and statistical manual of mental disorders, 3rd edn. APA, Washington DCGoogle Scholar
  3. Anderson J, Gordon E, Rennie C, Meares RA (1990) The quantification of variability in ERP’s and its application to schizophrenia (abstr no 6). Second international symposium of imaging of the brain in psychiatry and related fields, 13–16 June 1990 (SPECT)Google Scholar
  4. Andreasen NC (1983) Scale for the assessment for of negative symptoms (SANS). University of Iowa, Iowa City, p 17Google Scholar
  5. Andreasen NC, Olsen SA, Dennert JW et al. (1982) Ventricular enlargement in schizophrenia: relationship to positive and negative symptoms. Am J Psychiatry 139:297–302PubMedGoogle Scholar
  6. Andreasen NC, Nasrallah HA, Dunn V, Oslon SC, Grove WM, Ehrhardt JC, Coffman JA, Crosset LHW (1986) Structural abnormalities in the frontal system in schizophrenia. A magnetic resonance imaging study. Arch Gen Psychiatry 43:136–143PubMedGoogle Scholar
  7. Andreasen NC, Ehrhardt JC, Swayze VW, Alliger RJ, Yuh WTC, Cohen G, Ziebell S (1990) Magnetic resonance imaging of the brain in schizophrenia. Arch Gen Psychiatry 47:35–44PubMedGoogle Scholar
  8. Ariel RN, Golden CJ, Berg RA, Quaife MA, Dirksen JW, Forsell T, Wilson J, Graber B (1983) Regional cerebral blood flow in schizophrenics: test using the Xe 133 inhalation method. Arch Gen Psychiatry 40:258–263PubMedGoogle Scholar
  9. Ashtari M, Zito JL, Gold BI, Lieberman JA, Borenstein MT, Herman PG (1990) Computerized volume mensuration of brain structure. J Invest Radiol 27 (7): 798–805Google Scholar
  10. Averback P (1981) Structural lesions of the brain in young schizophrenics. J Can Sci Neurol 8 (1): 73–78Google Scholar
  11. Benes FM (1987) An analysis of the arrangement of neurons in the cingulate cortex of schizophrenic patients. Arch Gen Psychiatry 44:608–616PubMedGoogle Scholar
  12. Benes FM, Davidson B, Bird ED (1986) Quantitative cytoarchitectural studies of the cerebral cortex of schizophrenics. Arch Gen Psychiatry 43:31–35PubMedGoogle Scholar
  13. Besson JAO, Corrigan FM, Cherryman GR et al. (1987) Nuclear magnetic brain imaging in chronic schizophrenia. Br J Psychiatry 150:161–163PubMedGoogle Scholar
  14. Bishop RS, Golden CJ, MacInnes WD et al. (1983) The BPRS in assessing symptom correlates of cerebral ventricular enlargement in acute and chronic schizophrenia. Psychiatry Res 9:225–231PubMedGoogle Scholar
  15. Bogerts B (1984) Zur Neuropathologie der Schizophrenien. Fortschr Neurol Psychiatr 52:428–437PubMedGoogle Scholar
  16. Bogerts B (1985) Schizophrenien als Erkrankungen des limbischen Systems. In: Huber G (ed) Basisstadien endogener Psychosen und das Borderline-Problem. Schattauer, Stuttgart, pp 163–179Google Scholar
  17. Bogerts B (1989) Limbic and paralimbic pathology in schizophrenia: Interaction with age and stress related factors. In: Schulz SC, Tamminga CA (eds) Schizophrenia: scientific progress. Oxford University Press, pp 216–227Google Scholar
  18. Bogerts B (1990) The neuropathology of schizophrenia: pathophysiological and neurodevelopmental implications. In: Mednick SA, Cannon TD, Barr CE (eds) Fetal neural development and adult schizophrenia. Cambridge University Press, pp 153–173Google Scholar
  19. Bogerts B, Häntsch J, Herzer M (1983) A morphometric study of the dopamine containing cell groups in the mesencephalon of normals, Parkinson patients and schizophrenics. Biol Psychiatry 18:951–960PubMedGoogle Scholar
  20. Bogerts B, Meertz E, Schönfeld-Bausch R (1985) Basal ganglia and limbic system pathology in schizophrenia. Arch Gen Psychiatry 42:784–791PubMedGoogle Scholar
  21. Bogerts B, Falkai P, Tutsch J (1986) Cell numbers in the pallidum and hippocampus of schizophrenics. In: Shagass C et al. (eds) Biological psychiatry. Elsevier, Amsterdam, pp 1178–1180Google Scholar
  22. Bogerts B, Wurthmann C, Piroth HD (1987) Hirnsubstanzdefizit mit paralimbischem und limbischem Schwerpunkt im CT Schizophrener. Nervenarzt 58:97–106PubMedGoogle Scholar
  23. Bogerts B, Ashtari M, Degreef G, Alvir JMJ, Bilder RM, Lieberman JA (1990a) Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia. Psychiatry Res (Neuroimaging) 35:1–13Google Scholar
  24. Bogerts B, Falkai P, Haupts M, Greve B, Ernst S, Tapernon-Franz U, Heinzmann U (1990b) Post-mortem volume measurements of limbic system and basal ganglia structures in chronic schizophrenia. Schizophr Res 3:285–301Google Scholar
  25. Brown R, Colter N, Corsellis JAN, Crow TJ, Frith CD, Jagoe R, Johnstone EC, Marsh L (1986) Postmortem evidence of structural brain changes in schizophrenia. Differences in brain weight, temporal horn area and parahippocampal gyrus compared with affective disorder. Arch Gen Psychiatry 43:36–42PubMedGoogle Scholar
  26. Bruton CJ, Crow TJ, Frith CD, Johnstone EC, Owens DGC, Roberts GW (1990) Schizophrenia and the brain: a prospective clinico-neuropathological study. Psychol Med 20:285–304PubMedGoogle Scholar
  27. Buchsbaum MS, Ingvar DH, Kessler R et al. (1982) Cerebral glucography with positron tomography: use in normal subjects and in patients with schizophrenia. Arch Gen Psychiatry 39:251–259PubMedGoogle Scholar
  28. Buchsbaum MS, DeLisi LE, Holcomb HH et al. (1984) Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders. Arch Gen Psychiatry 41:1159–1166PubMedGoogle Scholar
  29. Christison GW, Casanova MF, Weinberger DR, Rawlings R, Kleinman JE (1989) A quantitative investigation of hippocampal pyramidal cell size, shape and variability of orientation in schizophrenia. Arch Gen Psychiatry 46:1027–1032PubMedGoogle Scholar
  30. Ciompi L (1980) The natural history of schizophrenia in the long term. Br J Psychiatry 136:413–420PubMedGoogle Scholar
  31. Colter N, Battal S, Crow TJ, Johnstone EC, Brown R, Bruton C (1987) White matter reduction in the parahippocampal gyrus of patients with schizophrenia. Arch Gen Psychiatry 44:1023PubMedGoogle Scholar
  32. Crow T (1980) Molecular pathology of schizophrenia: more than one dimension of pathology? Br Med J 280:66–68PubMedGoogle Scholar
  33. Crow TJ, Ball J, Bloom SR, Brown R, Bruton CJ, Colter N, Frith CD, Johnstone EC, Owens DGC, Roberts GW (1989) Schizophrenia as an anomaly of development of cerebral asymmetry. Arch Gen Psychiatr 46:1145–1150PubMedGoogle Scholar
  34. Curran JP, Cireilli VA (1988) The role psychosozial factors in the etiology, course and outcome of schizophrenia. In: Tsuang MT, Simpson JC (eds) Handbook of schizophrenia, vol 3. Elsevier, Amsterdam, pp 275–297Google Scholar
  35. Davison K, Bagley CR (1969) Schizophrenia-like psychosis associated with organic disorders of the central nervous system. A review of the literature. In: Hertington RN (ed) Current problems in neuropsychiatry, pp 113–187 (Br J Psychiatry Special Publication No 4)Google Scholar
  36. Degreef G, Ashtari M, Bogerts B, Bilder RM, Jody DN, Alvir JMJ, Lieberman JA (1991) Volumes of ventricular system subdivisions measured from magnetic resonance images in first episode schizophrenic patients. Arch Gen Psychiatry (in press)Google Scholar
  37. DeLisi LE, Dauphinais ID, Gershon E (1988) Perinatal complications and reduced size of brain limbic structures in familial schizophrenia. Schizophr Bull 14:185–191PubMedGoogle Scholar
  38. DeLisi LE, Buchsbaum MS, Holcomb HH et al. (1989) Increased temporal lobe glucose use in chronic schizophrenic patients. Biol Psychiatry 25:835–851PubMedGoogle Scholar
  39. DeMyer MK, Gilmor RL, Hendrie HC, DeMyer WE, Augustyn GT, Jackson RK (1988) Magnetic resonance brain images in schizophrenic and normal subjects: influence of diagnosis and education. Schizophr Bull 14:21–32PubMedGoogle Scholar
  40. Dom R, de Saedeler J, Bogerts B, Hopf A (1981) Quantitative cytometric analysis of basal ganglia in catatonic schizophrenics. In: Perris et al. (eds) Biological psychiatry. Elsevier, Amsterdam, pp 723–726Google Scholar
  41. Early TS, Reiman EM, Raichle ME et al. (1987) Left globus pallidus abnormality in never-medicated patients with schizophrenia. Proc Natl Acad Sci USA 84:561–563PubMedGoogle Scholar
  42. Endicott J, Spitzer RA (1978) A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 35:837–844PubMedGoogle Scholar
  43. Falkai P, Bogerts B (1986) Cell loss in the hippocampus of schizophrenics. Eur Arch Psychiatr Neurol Sci 236:154–161Google Scholar
  44. Falkai P, Bogerts B (1989) Morphometrie evidence for developmental disturbances in brains of some schizophrenics. Schizophr Res 2:99–100Google Scholar
  45. Falkai P, Bogerts B, Rozumek M (1988a) Cell loss and volume reduction in the entorhinal cortex of schizophrenics. Biol Psychiatry 24:515–521PubMedGoogle Scholar
  46. Falkai P, Bogerts B, Roberts GW, Crow TJ (1988b) Measurement of the alpha-cell-migration in the entorhinal region: a marker for developmental disturbances in schizophrenia? Schizophr Res 1:157–158Google Scholar
  47. Farkas T, Wolf AP, Jaeger J et al. (1984) Regional brain glucose metabolism in chronic schizophrenia: a positron emission transaxial tomographic study. Arch Gen Psychiatry 41:293–300PubMedGoogle Scholar
  48. Farmer A, Jackson R, McGuffin P, Storey P (1987) Cerebral ventricular enlargement in chronic schizophrenia: consistencies and contradictions. Br J Psychiatry 150:324–330PubMedGoogle Scholar
  49. Flor-Henry P (1969) Psychosis and temporal lobe epilepsy: a controlled investigation. Epilepsia 10:363–395PubMedGoogle Scholar
  50. Geraud G, Arne-Bes MC, Guell A, Bes A (1987) Reversibility of hemodynamic hypofron-tality in schizophrenia. J Cereb Blood Flow Metab 7:9–12PubMedGoogle Scholar
  51. Greenwood R, Bhalla A, Gordon A, Roberts J (1983) Behaviour disturbances during recovery from herpes simplex encephalitis. J Neurol Neurosurg Psychiatry 46:809–817PubMedGoogle Scholar
  52. Günther W (1990) Hirnfunktionsstörungen und Corpus-callosum Befunde bei Schizophrenen, gemessen mit EEG-Mapping, regionaler Hirndurchblutung und Kernspintomographie. In: Heinrich K, Bogerts B (eds) Pathophysiologische und pathomor-phologische Aspekte bei schizophrenen Psychosesn. Schattauer, Stuttgart, pp 97–113Google Scholar
  53. Günther W, Moser E, Petsch R, Brodie JD, Steinberg R, Streck P (1989) Pathological cerebral blood flow and corpus callosum abnormalities in schizophrenia: relations to EEG mapping and Pet data. Psychiatry Res 29:453–455Google Scholar
  54. Gur RE, Resnick SM, Alavi A et al. (1987a) Regional brain function in schizophrenia. I. A positron emission tomography study. Arch Gen Psychiatry 44:119–125PubMedGoogle Scholar
  55. Gur RE, Resnick SM, Gur RC et al. (1987b) Regional brain function in schizophrenia. II. Repeated evaluation with positron emission tomography. Arch Gen Psychiatry 44:126– 129PubMedGoogle Scholar
  56. Heath RG (1982) Psychosis and epilepsy: similarities and differences in the anatomic-physiologic substrate. In: Koella WP, Trimble MR (eds) Temporal lobe epilepsy, mania and schizophrenia and the limbic system. Karger, Basel, pp 106–116Google Scholar
  57. Heckers S, Heinsen H, Heinsen Y, Beckmann H (1990) Morphometry of the parahippo-campal gyrus in schizophrenics and controls. Some anatomical considerations. J Neural Transm 80:151–155Google Scholar
  58. Hillbom E (1951) Schizophrenia-like psychoses after brain trauma. Acta Psychiatr Neurol Scand 60:36–47Google Scholar
  59. Hoyer S, Oestreich K (1975) Blood flow and oxidative metabolism of the brain in patients with schizophrenia. Psychiatr Clin 8:304–313Google Scholar
  60. Ingvar DH, Franzen G (1974) Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatr Scand 50:425–462PubMedGoogle Scholar
  61. Jakob J, Beckmann H (1986) Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J Neural Transm 65:303–326PubMedGoogle Scholar
  62. Jeste DV, Lohr JB (1989) Hippocampal pathologic findings in schizophrenia. Arch Gen Psychiatry 46:1019–1024PubMedGoogle Scholar
  63. Johnstone EC, Crow TJ, Frith CD et al. (1976) Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet ii:924–926Google Scholar
  64. Johnstone EC, Crow TJ, Frith C, Stevens M, Kreel S, Husband J (1978) The dementia of dementia praecox. Acta Psychiatr Scand 57:305–324PubMedGoogle Scholar
  65. Johnstone EC, Crow TJ, MacMillan JF et al. (1986) A magnetic resonance study of early schizophrenia. J Neurol Neurosurg Psychiatry 49:317–321Google Scholar
  66. Johnstone EC, Owens DGC, Crow TJ, Frith CD, Alexandropolis K, Bydder G, Colter N (1989) Temporal lobe structure as determined by nuclear magnetic resonance in schizophrenia and bipolar affective disorder. J Neurol Neurosurg Psychiatry 52:736–741PubMedGoogle Scholar
  67. Jones EG, Powell TPS (1970) An anatomical study of converging sensory pathways within the cerebral cortex of the monkey. Brain 93:793–820PubMedGoogle Scholar
  68. Keefe RSE, Mohs RC, Losonczy MF et al. (1987) Characteristics of very poor outcome schizophrenia 144:889–894Google Scholar
  69. Keilp JG, Sweeney JA, Jacobsen P et al. (1988) Cognitive impairment in schizophrenia: specific relation to ventricular size and negative symptomatology. Biol Psychiatry 24:47– 55PubMedGoogle Scholar
  70. Kelsoe JR Jr, Cadet JL, Pickar D, Weinberger DR (1988) Quantitative neuroanatomy in schizophrenia: a controlled magnetic resonance imaging study. Arch Gen Psychiatry 45:533–541PubMedGoogle Scholar
  71. Kemali D, Maj M, Galderisi S (1987) Clinical, biological, and neuropsychological features associated with lateral ventricular enlargement in DSM-III schizophrenic disorder. Psychiatry Res 21:137–149PubMedGoogle Scholar
  72. Kling AS, Metter EJ, Riege WH et al. (1986) Comparison of PET measurement of local brain glucose metabolism and CAT measurement of brain atrophy in chronic schizophrenia and depression. Am J Psychiatry 143:175–180PubMedGoogle Scholar
  73. Kojima H, Yamada S, Nakamura J et al. (1987) Morphological changes of the brain in chronic schizophrenia. In: Takahashi R et al. (eds) Cerebral dynamics, laterality and psychopathology. Elsevier, AmsterdamGoogle Scholar
  74. Kolakowska T, Williams AO, Ardern M et al. (1985) Schizophrenia with good and poor outcome. I. Early clinical features, response to neuroleptics and signs of organic dysfunction. Br J Psychiatry 146:229–246PubMedGoogle Scholar
  75. Kovelman JA, Scheibel AB (1984) A neurohistological correlate of schizophrenia. Biol Psychiatry 19:1601–1621PubMedGoogle Scholar
  76. Kurachi M, Kobayashi K, Matsubara R, Hiramatsu H, Yamaguchi N, Matsuda H, Maeda T, Hisada K (1985) Regional blood flow in schizophrenic disorders. Eur Neurol 24:176–181PubMedGoogle Scholar
  77. Lesch A, Bogerts B (1984) The diencephalon in schizophrenia: evidence for reduced thickness of the periventricular grey matter. Eur Arch Psychiatr Neurol Sci 234:212–219Google Scholar
  78. Lohr JB, Jeste DV (1988) Locus ceruleus morphometry in aging and schizophrenia. Acta Psychiatr Scand 77:689–697PubMedGoogle Scholar
  79. Losonczy MF, Song IS, Mohs RC et al. (1986) Correlates of lateral ventricular size in chronic schizophrenia. I. Behavioral and treatment response measures. Am J Psychiatry 143:976–981PubMedGoogle Scholar
  80. Luchins D, Lewine R, Meltzer H (1984) Lateral ventricular size, psychopathology and medication response in the psychoses. Biol Psychiatry 19:29–44PubMedGoogle Scholar
  81. Luchins DL, Metz JT, Marks RC, Cooper MD (1989) Basal ganglia glucose metabolism asymmetry during a catatonic episode. Biol Psychiatry 26:725–728PubMedGoogle Scholar
  82. Malamud M (1967) Psychiatric disorder with intracranial tumors of the limbic system. Arch Neurol 17:113–123PubMedGoogle Scholar
  83. Marks RC, Luchins DJ (1990) Relationship between brain imaging findings in schizophrenia and psychopathology. In: Andreasen NC (ed) Schizophrenia: positive and negative symptoms and syndromes. Karger, Basel, pp 89–123Google Scholar
  84. Mathew PJ, Partain CL (1985) Midsagittal sections of the cerebellar vermis and fourth ventricle obtained with magnetic resonance imaging in schizophrenic patients. Am J Psychiatry 142 (8): 970–971PubMedGoogle Scholar
  85. Mathew PJ, Partain CL, Prakash R, Kulkarni MV, Logan TP, Wilson WH (1985) A study of the septum pellucidum and corpus callosum in schizophrenia with MR imaging. Acta Psychiatr Scand 72 (5): 414–421PubMedGoogle Scholar
  86. Mathew RJ, Barr DL, Weinman ML, Barr DL (1982) Regional blood flow in schizophrenia. Arch Gen Psychiatry 39:1121–1124PubMedGoogle Scholar
  87. Mathew RJ, Wilson WH, Tant SR, Robinson L, Prakash R (1988) Abnormal resting regional blood flow patterns and their correlates in schizophrenia. Arch Gen Psychiatry 45:542–549PubMedGoogle Scholar
  88. McCarley RW, Faux SF, Shenton M, LeMay M, Cane M, Ballinger R, Duffy PH (1989) CT abnormalities in schizophrenia. A preliminary study of their correlations with P300/P200. Electrophysiological features and positive/negative symptoms. Arch Gen Psychiatry 46:698–708PubMedGoogle Scholar
  89. McKenna PJ (1987) Pathology, phenomenology and the dopamine hypothesis of schizophrenia. Br J Psychiatry 151:288–301PubMedGoogle Scholar
  90. McLardy T (1974) Hippocampal zinc and structural deficits in brains from chronic alcoholics and some schizophrenics. J Orthomol Psychiatry 4:32–36Google Scholar
  91. Meltzer HY, Stahl SM (1976) The dopamine hypothesis of schizophrenia: a review. Schizophr Bull 2:19–76PubMedGoogle Scholar
  92. Mesulam MM (1986) Patterns in behavioral neuroanatomy: association areas, the limbic system, and hemispheric specialization. In: Mesulam MM (ed) Principles of behavioral neurology. Davis, Philadelphia, pp 1–70Google Scholar
  93. Moscarelli M, Cesana BM, Ciussani S et al. (1989) Ventricle-brain ratio and alogia in 19 young patients with chronic negative and positive schizophrenia. Am J Psychiatry 146:257–258PubMedGoogle Scholar
  94. Mulder DW, Daly D (1952) Psychiatric symptoms associated with lesions of the temporal lobe. JAMA 150:173–176Google Scholar
  95. Mundt CH, Radü W, Glück E (1980) Computertomographische Untersuchungen der Liquorräume an chronisch schizophrenen Patienten. Nervenarzt 51: 743–748PubMedGoogle Scholar
  96. Nasrallah HA, Jacoby CG, McCalley-Whitters M, Kuperman S (1982) Cerebral ventricular enlargement in subtypes of chronic schizophrenia. Arch Gen Psychiatry 39:774–777PubMedGoogle Scholar
  97. Nasrallah HA, Kuperman S, Jacoby CG et al. (1983a) Clinical correlates of sulcal widening in chronic schizophrenia. Psychiatry Res 10:237–242PubMedGoogle Scholar
  98. Nasrallah HA, Kuperman S, Hamra B, McCalley-Whitters M (1983b) Clinical differences between schizophrenic patients with and without large cerebral ventricles. J Clin Psychiatry 44:407–409PubMedGoogle Scholar
  99. Nasrallah HA, McCalley-Whitters M, Rauscher FP et al. (1983c) A histological study of the corpus callosum in chronic schizophrenia. Psychiatry Res 8:151–160Google Scholar
  100. Nasrallah HA, Andreasen NC, Coffman JA, Olson SC, Dunn VD, Ehrhardt JC, Chapman SM (1986) A controlled magnetic resonance imaging study of corpus callosum thickness in schizophrenia. Biol Psychiatry 21:274–282PubMedGoogle Scholar
  101. Nieto D, Escobar A (1972) Major psychoses. In: Minkler J (ed) Pathology of the nervous system. McGraw-Hill, New York, pp 2654–2665Google Scholar
  102. Ota T, Maeshiro H, Ishido H et al. (1987) Treatment-resistant chronic psychopathology and CT scans in schizophrenia. Acta Psychiatr Scand 75:415–427PubMedGoogle Scholar
  103. Ounsted C, Lindsley J (1981) The long-term outcome of temporal lobe epilepsy in childhood. In: Reynolds EH, Trimble MR (eds) Epilepsy and psychiatry. Churchill Livingstone, Edinburgh, pp 185–215Google Scholar
  104. Owens D, Johnstone E, Crow T et al. (1985) Lateral ventricular size in schizophrenia: relationship to the disease process and its clinical manifestations. Psychol Med 15:27–41PubMedGoogle Scholar
  105. Pakkenberg B (1987) Post-mortem study of chronic schizophrenic brains. Br J Psychiatry 151:744–752PubMedGoogle Scholar
  106. Palkovits M, Zaborski L (1979) Neural connections of the hypothalamus. In: Morgane PJ (ed) Anatomy of the hypothalamus. Decker, New York, pp 379–509Google Scholar
  107. Pandurangi A, Dewan M, Boucher M et al. (1986) A comprehensive study of chronic schizophrenic patients. II. Biological, neuropsychological, and clinical correlates of CT abnormality. Acta Psychiatr Scand 73:161–171PubMedGoogle Scholar
  108. Pearlson G, Garbacz D, Breakey W et al. (1984) Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder. Psychiatry Res 12:1–9PubMedGoogle Scholar
  109. Pearlson GD, Garbacz DJ, Moberg PJ et al. (1985) Symptomatic familial, perinatal, and social correlates of computerized axial tomography (CAT) changes in schizophrenics and bipolars. J Nerv Ment Dis 173:42–50PubMedGoogle Scholar
  110. Pearlson GD, Kim WS, Kubos KL, Moberg PJ, Jayaram G, Bascom MJ, Chase GA, Goldfinger AD, Tune LE (1989) Ventricle-brain ratio, computed tomographic density and brain area in 50 schizophrenics. Arch Gen Psychiatry 46:690–697PubMedGoogle Scholar
  111. Perez MM, Trimble MR, Reider I, Murray M (1984) Epileptic psychosis, a further evaluation of PSE profiles. Br J Psychiatry 146:155–163Google Scholar
  112. Pfefferbaum A, Zipursky RB, Lim KO et al. (1988) Computed tomographic evidence for generalized sulcal and ventricular enlargement in schizophrenia. Arch Gen Psychiatry 45:633–640PubMedGoogle Scholar
  113. Risberg J, Warkentin S, Graae E, Nilsson A, Franzen G (1990) Regional cerebral blood flow in schizophrenia. Second International Symposium Imaging of the Brain in Psychiatry and Related Fields, 13–16 June 1990 (abstr no 90)Google Scholar
  114. Rossi A, Stratta P, Gallucci M, Passarellio R, Cassachia M (1989) Quantification of corpus callosum and ventricles in schizophrenia with nuclear magnetic resonance imaging: a pilot study. Am J Psychiatry 146:99–101PubMedGoogle Scholar
  115. Rossi A, Stratta P, D’Albenzio L, Tartaro A, Schiazza G, di Michele V, Bolino F, Casacchia M (1990) Reduced temporal lobe areas in schizophrenia: preliminary evidences from a controlled multiplanar magnetic resonance imaging study. Biol Psychiatry 27:61–68PubMedGoogle Scholar
  116. Sagawa K, Kawakatsu S, Shibuya I et al. (1990) Correlation of regional cerebral blood flow with performance on neuropsychological tests in schizophrenic patients. Schizophrenia Res 3:241–246Google Scholar
  117. Scheibel AB, Kovelman JA (1981) disorientation of the hippocampal pyramidal cells and its processes in the schizoprenic patient. Biol Psychiatry 16:101–102Google Scholar
  118. Schmajuk NA (1987) Animal models for schizophrenia: the hippocampally lesioned animal. Schizophr Bull 13(2):317–327PubMedGoogle Scholar
  119. Serban G, George A, Siegel S, DeLeon M, Gaffney M (1990) Computed tomography scans and negative symptoms in schizophrenia: chronic schizophrenics with negative symptoms and nonenlarged lateral ventricles. Acta Psychiatr Scand 81:441–447PubMedGoogle Scholar
  120. Shelton RC, Weinberger DR (1986) X-ray computerized tomography studies in schizophrenia: a review and synthesis. In: Nasrallah HA, Weinberger DR (eds) The neurology of schizophrenia. Elsevier, New York, pp 207–250Google Scholar
  121. Sheppard G, Gruzelier J, Manchanda R, Hirsch SR (1983) 15-0 Positron emission tomographic scanning in predominantly never treated acute schizophrenic patients. Lancet ii: 1448–1452Google Scholar
  122. Sherwin I (1982) The effect of the location of an epileptogenic lesion on the occurrence of psychosis in epilepsy. In: Koella W, Trimble MR (eds) Temporal lobe epilepsy, mania and schizophrenia and the limbic system. Karger, Basel, pp 81–97Google Scholar
  123. Salter E, Beard AW, Glithero E (1963) The schizophrenia-like psychosis of epilepsy. Br J Psychiatry 109:95–150Google Scholar
  124. Smith RC, Calderon M, Ravichandran GK, Largen J, Vroulis G, Shvartsburd A, Gordon J, Schoolar JC (1984) Nuclear magnetic resonance in schizophrenia: a preliminary study. Psychiatry Res 12(2): 137–147PubMedGoogle Scholar
  125. Smith RC, Baumgartner R, Calderon M (1987) Magnetic resonance imaging studies of the brains of schizophrenic patients. Psychiatry Res 20(1): 33–46PubMedGoogle Scholar
  126. Stevens JR (1982) Neuropathology of schizophrenia. Arch Gen Psychiatry 39:1131–1139PubMedGoogle Scholar
  127. Stevens JR (1986) Clinicopathological correlations in schizophrenia. Arch Gen Psychiatry 43:715–716PubMedGoogle Scholar
  128. Stratta P, Rossi A, Gallucci M, Amicarelli I, Passariello R, Casacchia M (1989) Hemispheric asymmetries and schizophrenia: a preliminary magnetic resonance imaging study. Biol Psychiatry 25:275–284PubMedGoogle Scholar
  129. Suddath RL, Casanova FMF, Goldberg TE, Daniel DG, Kelsoe J, Weinberger DR (1989a) Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study. Am J Psychiatry 146:464–472PubMedGoogle Scholar
  130. Suddath RL, Christison GW, Torrey EF, Casanova MF, Weinberger DR (1990) Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N Engl J Med 322 (12): 62–67Google Scholar
  131. Swanson LW (1983) The hippocampus and the concept of limbic system. In: Scifert W (ed) Neurobiology of the hippocampus. Academic, London, pp 3–19Google Scholar
  132. Swanson LW, Köhler C (1986) Anatomical evidence for direct projections from the entorhinal area to the entire cortical mantle in the rat. J Neurosci 6:3010–3023PubMedGoogle Scholar
  133. Szechtman H, Nahmias C, Garnett S et al. (1988) Effect of neuroleptics on altered cerebral glucose metabolism in schizophrenia. Arch Gen Psychiatry 45:523–532PubMedGoogle Scholar
  134. Tamminga CA, Thaker GK, Alphs LD, Chase TN (1989) Limbic system: localization of PCP drug action in rat and schizophrenic manifestions in humans. In: Schulz SW, Tamminga CA (eds) Schizophrenia: scientific progress. Oxford University Press, 162– 172Google Scholar
  135. Tandon R, Greden JF (1990) Cholinergic hyperactivity and negative schizophrenic symptoms. Arch Gen Psychiatry 46:745–753Google Scholar
  136. Trimble MR (1986) Pet in epilepsy. In: Trimble MR, Bolwig T (eds) Aspects of epilepsy and psychiatry. Wiley, Chichester, pp 147–160Google Scholar
  137. Uematso M, Kaiya H (1988) The morphology of the corpus callosum in schizophrenia: an MRI study. Schizophr Res 1:391–398Google Scholar
  138. Van Kammen DP, Van Kammen WB, Peters J et al. (1988) Decreased slow-wave sleep and enlarged ventricles in schizophrenia. Neuropsychopharmacology 1:265–271PubMedGoogle Scholar
  139. Warkentin S, Nilsson A, Risberg J et al. (1990) Regional cerebral blood flow in schizophrenia: repeated studies during a psychotic episode. Psychiatry Res (Neuroimaging) 35:27–38Google Scholar
  140. Weinberger DR (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 44:660–669PubMedGoogle Scholar
  141. Weinberger DR, Cannon-Spoor E, Potkin SG, Wyatt RJ (1980) Poor premorbid adjustment and CT scan abnormalities in chronic schizophrenia. Am J Psychiatry 137:1410–1413PubMedGoogle Scholar
  142. Weinberger DR, Berman KF, Zee RF (1986) Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. regional cerebral blood flow (RCBF) evidence. Arch Gen Psychiatry 43:114–125PubMedGoogle Scholar
  143. Wieser HG (1982) Zur Frage der lokalisatorischen Bedeutung epileptischer Halluzinationen. In: Karbowski K (ed) Halluzinationen bei Epilepsien und ihre Differentialdiagnose. Huber, Bern, pp 67–92Google Scholar
  144. Williams AO, Reveley MA, Kolakowska T (1985b) Schizophrenia with good and poor outcome. II. Cerebral ventricular size and its clinical significance. Br J Psychiatry 146:239–246PubMedGoogle Scholar
  145. White TD, Tan AM, Finch DM (1991) Functional reciprocal connections of the rat entorhinal cortex and subicular complex with the medial frontal cortex: an in vivo intracellular study. Brain Res (in press)Google Scholar
  146. Wolkin JA, Jaeger J, Brodie JD et al. (1988) Low frontal glucose utilisation in chronic schizophrenia: a replication study. Am J Psychiatry 145:251–253PubMedGoogle Scholar
  147. Wolkin JA, Jaeger J, Brodie JD et al. (1985) Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography. Am J Psychiatry 142:564–571PubMedGoogle Scholar
  148. Zubin J, Spring B (1977) Vunerability-a new view of schizophrenia. J Abnorm Psychol 86:103–126PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • A. Bogerts
    • 1
  • P. Falkai
    • 1
  • G. Degreef
    • 2
  • J. A. Lieberman
    • 2
  1. 1.Psychiatrische KlinikUniversität DüsseldorfDüsseldorfGermany
  2. 2.Hillside HospitalLong Island Jewish Medical CenterGlen OaksUSA

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