Monoclonal Blast Cell Proliferation in Transient Myeloproliferative Disorders
Transient myeloproliferative disorder is a hematological condition observed during the neonatal period in patients with Down syndrome. This disorder mimics congenital leukemia and the blast cells were often reported to show characteristics compatible with those of mega-karyoblasts  or pluripotent stem cells . Although this disorder usually resolves gradually without antileukemic treatment, in some patients, leukemia develops after periods of spontaneous remission , raising questions about the benign origin of this disorder.
KeywordsDown Syndrome Blast Cell Phosphoglycerate Kinase Blastic Phase Remission Phase
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