Monoclonal Blast Cell Proliferation in Transient Myeloproliferative Disorders

  • T. Miyashita
  • S. Mizutani
  • M. Asada
  • J. Fujimoto
  • T. Inaba
  • T. Furukawa
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 35)


Transient myeloproliferative disorder is a hematological condition observed during the neonatal period in patients with Down syndrome.[1] This disorder mimics congenital leukemia and the blast cells were often reported to show characteristics compatible with those of mega-karyoblasts [2] or pluripotent stem cells [3]. Although this disorder usually resolves gradually without antileukemic treatment, in some patients, leukemia develops after periods of spontaneous remission [4], raising questions about the benign origin of this disorder.


Down Syndrome Blast Cell Phosphoglycerate Kinase Blastic Phase Remission Phase 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • T. Miyashita
    • 1
  • S. Mizutani
    • 1
  • M. Asada
    • 1
  • J. Fujimoto
    • 2
  • T. Inaba
    • 3
  • T. Furukawa
    • 4
  1. 1.Department of VirologyThe National Children’s Medical Research CenterTokyoJapan
  2. 2.Department of PathologyThe National Children’s Medical Research CenterTokyoJapan
  3. 3.Department of Hematology/OncologySaitama Children’s HospitalSaitamaJapan
  4. 4.Department of PediatricsDokkyo University Medical SchoolTochigiJapan

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