Advertisement

Monoclonal Blast Cell Proliferation in Transient Myeloproliferative Disorders

  • T. Miyashita
  • S. Mizutani
  • M. Asada
  • J. Fujimoto
  • T. Inaba
  • T. Furukawa
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 35)

Abstract

Transient myeloproliferative disorder is a hematological condition observed during the neonatal period in patients with Down syndrome.[1] This disorder mimics congenital leukemia and the blast cells were often reported to show characteristics compatible with those of mega-karyoblasts [2] or pluripotent stem cells [3]. Although this disorder usually resolves gradually without antileukemic treatment, in some patients, leukemia develops after periods of spontaneous remission [4], raising questions about the benign origin of this disorder.

Keywords

Down Syndrome Blast Cell Phosphoglycerate Kinase Blastic Phase Remission Phase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Nagao T, Lampkin BC, Hug G (1970) A neonate with Down’s syndrome and transient abnormal myelopoiesis: serial blood and bone marrow studies. Blood 36:443–447PubMedGoogle Scholar
  2. 2.
    Koike T, Aoki S, Maruyama S, Narita M, Ishizuka T, Imanaka H, Adachi T, Maeda H, Shibata A (1987) Cell surface pheno-typing of megakaryoblasts. Blood 69:957–962PubMedGoogle Scholar
  3. 3.
    Suda J, Eguchi M, Akiyama Y, Iwama Y, Furukawa T, Sato Y, Miura Y, Suda T, Saito M (1987) Differentiation of blast cells from a Down’s syndrome patient with transient myeloproliferative disorder. Blood 69:508–513PubMedGoogle Scholar
  4. 4.
    Morgan R, Hecht F, Cleary ML, Sklar J, Link MP (1985) Leukemia with Down’s syndrome: translocation between chromosomes 1 and 19 in acute myelomonocytic leukemia following transient congenital myeloproliferative syndrome. Blood 66:1466–1471PubMedGoogle Scholar
  5. 5.
    Nakagawa T, Nishida H, Arai T, Yamada T, Fukuda M, Sukamoto S (1988) Hyperviscosity syndrome with transient abnormal myelopoiesis in Down syndrome. J Pediatr 112:58–61PubMedCrossRefGoogle Scholar
  6. 6.
    Nakamura K, Sasaki M, Fujimoto J, Enomoto Y, Kaneko Y, Ozaki M, Miyashita T, Tsunematsu Y, Hata J, Kobayashi N, Mizutani S (1990) Molecular diversity of precursor B acute lymphoblastic leuke-mias identified by the immunoglobulin heavy chain gene organization. Leukemia 4:106–111PubMedGoogle Scholar
  7. 7.
    Keith DH, Singer-Sam J, Riggs AD (1986) Active X chromosome DNA is unmethy-lated at eight CCGG sites clustered in a guanine-plus-cytosine-rich island at the 5’ end of the gene for phosphoglycerate kinase. Mol Cell Biol 6:4122–4128PubMedGoogle Scholar
  8. 8.
    Vogelstein B, Fearon ER, Hamilton SR, Feinberg AP (1985) Use of restriction fragment length polymorphisms to determine the clonal origin of human tumors. Science 227:642–646PubMedCrossRefGoogle Scholar
  9. 9.
    Nakazawa S, Sugita K (1987) Establishment and characterization of a murine anti-platelet monoclonal antibody and its usefulness for the identification of megakaryocyte-lineage cells. Keio J Med 36:53–58PubMedCrossRefGoogle Scholar
  10. 10.
    Asou N, Hattori T, Matsuoka M, Kawano F, Takatsuki K (1989) Rearrangements of T-ell antigen receptor δ chain gene in hematologic neoplasms. Blood 74:2707–2712PubMedGoogle Scholar
  11. 11.
    Zipursky A, Peeters M, Poon A (1986) Megakaryoblastic leukemia and Down’s syndrome—a review. In: McCoy EE, Epstein CJ (eds) Oncology and immunology of Down syndrome. Liss, New York, pp 33–56Google Scholar
  12. 12.
    Ikebuchi K, Wong GG, Clark SC, Ihle JN, Hirai Y, Ogawa M (1987) Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hematopoietic progenitors. Proc Natl Acad Sci USA 84:9035–9040PubMedCrossRefGoogle Scholar
  13. 13.
    Lazarus KH, Heerema NA, Palmer CG, Baehner RL (1981) The myeloproliferative reaction in a child with Down syndrome: cytologicai and chromosomal evidence for a transient leukemia. Am J Hematol 11:417–422PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • T. Miyashita
    • 1
  • S. Mizutani
    • 1
  • M. Asada
    • 1
  • J. Fujimoto
    • 2
  • T. Inaba
    • 3
  • T. Furukawa
    • 4
  1. 1.Department of VirologyThe National Children’s Medical Research CenterTokyoJapan
  2. 2.Department of PathologyThe National Children’s Medical Research CenterTokyoJapan
  3. 3.Department of Hematology/OncologySaitama Children’s HospitalSaitamaJapan
  4. 4.Department of PediatricsDokkyo University Medical SchoolTochigiJapan

Personalised recommendations