A Novel Nuclear Factor Binds to the NF-ΚB Motif in the Interleukin-2 Enhancer

  • S.-M. Kang
  • M. Grilli
  • A.-C. Tran
  • M. J. Lenardo
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 35)


An important aspect of T-lymphocyte physiology is the necessity for exquisitely tight control of interleukin-2 (IL-2) gene expression. IL-2 is produced only by T cells with extremely transient kinetics [1] (S. Kang, M. Lenardo, unpublished results). Moreover, in nontransformed T cells, significant transcription of the IL-2 gene appears to occur only in the presence of T-cell receptor signaling coupled with an as yet ill-defined “costimulatory signal” present on the surface of competent antigen presenting cells [2, 3]. Further evidence of fine control in IL-2 production is found in the TH1/TH2 subdivision of T cells in the murine system: after signaling through apparently the same T cell receptor apparatus, the TH1 pheno-type produces a lymphokine profile which includes IL-2 while the TH2 phenotype does not [4].


Leukemia Cyclosporin Purine Nism Thymoma 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • S.-M. Kang
    • 2
  • M. Grilli
  • A.-C. Tran
  • M. J. Lenardo
    • 1
  1. 1.Laboratory of Immunology, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA
  2. 2.HHMI-NIH Research ScholarUSA

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