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A Novel Nuclear Factor Binds to the NF-ΚB Motif in the Interleukin-2 Enhancer

  • S.-M. Kang
  • M. Grilli
  • A.-C. Tran
  • M. J. Lenardo
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 35)

Abstract

An important aspect of T-lymphocyte physiology is the necessity for exquisitely tight control of interleukin-2 (IL-2) gene expression. IL-2 is produced only by T cells with extremely transient kinetics [1] (S. Kang, M. Lenardo, unpublished results). Moreover, in nontransformed T cells, significant transcription of the IL-2 gene appears to occur only in the presence of T-cell receptor signaling coupled with an as yet ill-defined “costimulatory signal” present on the surface of competent antigen presenting cells [2, 3]. Further evidence of fine control in IL-2 production is found in the TH1/TH2 subdivision of T cells in the murine system: after signaling through apparently the same T cell receptor apparatus, the TH1 pheno-type produces a lymphokine profile which includes IL-2 while the TH2 phenotype does not [4].

Keywords

Chain Enhancer Light Chain Enhancer Mouse Fibroblast Line Light Chain Precursor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • S.-M. Kang
    • 2
  • M. Grilli
  • A.-C. Tran
  • M. J. Lenardo
    • 1
  1. 1.Laboratory of Immunology, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA
  2. 2.HHMI-NIH Research ScholarUSA

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