Tumor Rejection Antigens and Immune Surveillance
The existence of specific tumor rejection antigens was first demonstrated with chemically induced mouse sarcomas: each tumor was found to express a different antigen . Similar findings were made with ultraviolet-induced tumors . Later, the generality of the existence of tumor rejection antigens was questioned when spontaneous mouse tumors were found to be completely incapable of eliciting an immune rejection response . However, further experiments demonstrated that even these tumors express weak transplantation antigens that are potential targets for immune rejection by the syngeneic host .
KeywordsLeukemia Influenza Sarcoma Arginine Histidine
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