Tumor Rejection Antigens and Immune Surveillance
The existence of specific tumor rejection antigens was first demonstrated with chemically induced mouse sarcomas: each tumor was found to express a different antigen . Similar findings were made with ultraviolet-induced tumors . Later, the generality of the existence of tumor rejection antigens was questioned when spontaneous mouse tumors were found to be completely incapable of eliciting an immune rejection response . However, further experiments demonstrated that even these tumors express weak transplantation antigens that are potential targets for immune rejection by the syngeneic host .
KeywordsMast Cell Line Transplantation Antigen Mouse Tumor Cell Tumor Rejection Antigen Normal Peptide
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- 1.Prehn RT, Main JM (1957) Immunity to methylcholanthrene-induced sarcomas. INCI 18:769Google Scholar
- 13.Wölfel T, van Pel A, de Plaen E, Lurquin C, Maryanski JL, Boon T (1987) Immunoenic (tum-) variants obtained by mutagenesis of mouse mastocytoma P815. Detection of stable transfectants expressing a tun - antigen with a cytolytic T cell stimulation assay. Immunogenetics 26:178PubMedCrossRefGoogle Scholar