Analysis of Human Retroviral Regulatory Proteins Tax and Tat
The human retroviruses HTLV-I (human T-cell leukemia virus) and HIV-1 (human immunodeficiency virus) code, in addition to a complete set of replicatory genes (gag, pol, and env), for several regulatory genes including the trans-activators tax and tat, respectively, both of which lead to high expression of viral gene products. The molecular mechanism underlying these events is, however, different for the two proteins.
KeywordsNuclear Extract Jurkat Cell Immunoaffinity Column Viral Gene Product CREB Protein
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