Analysis of Human Retroviral Regulatory Proteins Tax and Tat

  • U. Lorenz
  • P. Beimling
  • J. Cao
  • K. Moelling
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 35)


The human retroviruses HTLV-I (human T-cell leukemia virus) and HIV-1 (human immunodeficiency virus) code, in addition to a complete set of replicatory genes (gag, pol, and env), for several regulatory genes including the trans-activators tax and tat, respectively, both of which lead to high expression of viral gene products. The molecular mechanism underlying these events is, however, different for the two proteins.


Nuclear Extract Jurkat Cell Immunoaffinity Column Viral Gene Product CREB Protein 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • U. Lorenz
    • 1
  • P. Beimling
    • 1
  • J. Cao
    • 2
  • K. Moelling
    • 1
  1. 1.Abt. SchusterMax-Planck-Institut für Molekulare GenetikBerlin 33Germany
  2. 2.Gesellschaft für Biotechnologische Forschung mbHBrunswickGermany

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