Skip to main content

Analysis of Human Retroviral Regulatory Proteins Tax and Tat

  • Conference paper
Modern Trends in Human Leukemia IX

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 35))

  • 54 Accesses

Abstract

The human retroviruses HTLV-I (human T-cell leukemia virus) and HIV-1 (human immunodeficiency virus) code, in addition to a complete set of replicatory genes (gag, pol, and env), for several regulatory genes including the trans-activators tax and tat, respectively, both of which lead to high expression of viral gene products. The molecular mechanism underlying these events is, however, different for the two proteins.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Beimling P, Moelling K (1989) Isolation and characterization of the Tax protein of HTLV-I. Oncogene 4:511–516

    PubMed  CAS  Google Scholar 

  2. Beimling P, Moelling K (1990) Tax-independent binding of multiple cellular factors to Tax-response element DNA of HTLV-L. Oncogene 5:361–368

    PubMed  CAS  Google Scholar 

  3. Cullen BR (1990) The HIV-1 Tat protein: an RNA sequence-specific processivity factor. Cell 63:655–657

    Article  PubMed  CAS  Google Scholar 

  4. Remaut E, Stanssens P, Fiers W (1983) Inducible high level synthesis of mature human fibroblast interferon in Escherichia coli. Nucleic Acids Res 11:4677–4688

    Article  PubMed  CAS  Google Scholar 

  5. Ratner L, Haseltine W, Patarca R, Livak KJ, Starcich B, Josephs SF, Doran ER, Rafalski JA, Whitehorn EA, Baumeister K, Ivanoff L, Petteway Jr SR, Pearson ML, Lautenberger JA, Papas TS, Ghrayeb J, Chang NT, Gallo RC, Wong-Staal F (1985) Complete nucleotide sequence of the AIDS virus, HTLV-IIL. Nature 313:277–284

    Article  PubMed  CAS  Google Scholar 

  6. Salahuddin SZ, Markham PD, Wong-Staal F, Franchini G, Kalyanaraman VS, Gallo RC (1983) Restricted expression of human T-cell leukemia virus (HTLV) in transformed human umbilical cord blood lymphocytes. Virology 129:51–64

    Article  PubMed  CAS  Google Scholar 

  7. Dayton AI, Sodroski JG, Rosen CA, Goh WC, Haseltine WA (1986) The trans-activator gene of the human T-cell lympho-tropic virus type III is required for replication. Cell 44:941–947

    Article  PubMed  CAS  Google Scholar 

  8. Gonzalez GA, Yamamoto UK, Fischer WH, Karr D, Menzel P, Biggs III W, Vale WW, Montminy RR (1989) A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence. Nature 337:749–752

    Article  PubMed  CAS  Google Scholar 

  9. Hager DA, Burgess RR (1980) Elution of proteins from sodium dodecyl sulfate-polyacrylamide gels, removal of sodium dodecyl sulfate, and renaturation of enzymatic activity: results with sigma subunit of Escherichia coli RNA polymerase, wheat germ DNA topoisomerase and other enzymes. Anal Biochem 109:76–86

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Lorenz, U., Beimling, P., Cao, J., Moelling, K. (1992). Analysis of Human Retroviral Regulatory Proteins Tax and Tat. In: Neth, R., Frolova, E., Gallo, R.C., Greaves, M.F., Afanasiev, B.V., Elstner, E. (eds) Modern Trends in Human Leukemia IX. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 35. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76829-3_35

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-76829-3_35

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-54360-2

  • Online ISBN: 978-3-642-76829-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics