The Molecular Biology of the Myeloproliferative Leukemia Virus
Most acutely transforming leukemogenic or sarcomagenic retroviruses have transduced in their genomes altered cellular genes named oncogenes . These viruses are usually defective in replication as a result of the deletion of structural genes, and they require a helper virus for propagation. Isolation of new acutely transforming retroviruses, comprehensive studies of their physiopathological processes, and molecular analysis of their genomes remain, therefore, powerful means for the identification of key genes involved in the regulation of cell growth, differentiation, or development.
KeywordsHelper Virus Permanent Cell Line Growth Factor Requirement Nonproducer Cell Mink Cell
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