The Molecular Biology of the Myeloproliferative Leukemia Virus

  • F. Wendling
  • M. Souyri
  • I. Vigon
  • S. Gisselbrecht
  • P. Tambourin
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 35)


Most acutely transforming leukemogenic or sarcomagenic retroviruses have transduced in their genomes altered cellular genes named oncogenes [1]. These viruses are usually defective in replication as a result of the deletion of structural genes, and they require a helper virus for propagation. Isolation of new acutely transforming retroviruses, comprehensive studies of their physiopathological processes, and molecular analysis of their genomes remain, therefore, powerful means for the identification of key genes involved in the regulation of cell growth, differentiation, or development.


Helper Virus Permanent Cell Line Growth Factor Requirement Nonproducer Cell Mink Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • F. Wendling
    • 1
  • M. Souyri
    • 2
  • I. Vigon
    • 2
  • S. Gisselbrecht
    • 2
  • P. Tambourin
    • 3
  1. 1.Unité de Recherche en Genetique Moleculaire et en Hematologie, INSERM U.91 -CNRS UA 607Hôpital Henri MondorCreteilFrance
  2. 2.INSERM U 152, Institut Cochin de Génétique Moléculaire (ICGM)Hôpital CochinParisFrance
  3. 3.Institut CurieParisFrance

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