Molecular Mechanisms in Myeloid Lineage Development

  • L. R. Rohrschneider
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 35)


Recent work from my laboratory has described a new mechanism for controlling the expression of one hematopoietic colony-stimulating factor (CSF) receptor by the interaction of another CSF with its receptor [1]. This type of transmodulation occurs at the level of mRNA stability and has interesting implications for hematopoietic cell development. It is particularly relevant to mechanisms that determine myeloid lineage restriction and its potential involvement in this process will be presented and analyzed.


Mixed Coloni Murine Bone Marrow Cell Granulocytic Cell Hemopoietic Precursor Cell Bipotential Progenitor Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • L. R. Rohrschneider
    • 1
  1. 1.Cell Biology DepartmentFred Hutchinson Cancer Research CenterSeattleUSA

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