Structural Changes in Blast Cell Chromatin and DNA in Patients with Acute Leukemia After Cytosar and Irradiation Treatment

  • J. Monaselidze
  • Z. Chanchalashvili
  • I. Kalandadze
  • D. Khachidze
  • I. Topuridze
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 35)

Abstract

It is known that chromatin DNA is the main target for many drugs in the living cell. Drugs which bind with double helix DNA are divided into two classes:
  1. 1)

    those which directly interact with DNA and change its stability and conformation and

     
  2. 2)

    those which indirectly influence DNA.

     

Cytosar (or β-cytosine arabinoside) belongs to the first class of drugs. Influence of Cytosar on DNA and RNA is not restricted only to its binding with these structures. It also makes ruptures in double helix DNA, causing cell destruction [1].

Keywords

Enthalpy Leukemia Calorimetry Arabinoside Micro Calorimetry 

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References

  1. 1.
    Momparler RL (1974) Cancer Res 34:1775PubMedGoogle Scholar
  2. 2.
    Monaselidze JR et al. (1986) USSR authors certificate N 1267175Google Scholar
  3. 3.
    Andronikashvili EL, Monaselidze JR, et al. (1988) In: Sigel H (ed) Metal ions in biological systems, vol 23. Dekker, New YorkGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • J. Monaselidze
    • 1
  • Z. Chanchalashvili
    • 1
  • I. Kalandadze
    • 1
  • D. Khachidze
    • 1
  • I. Topuridze
    • 2
  1. 1.Institute of PhysicsGeorgian Academy of SciencesTbilisiUSSR
  2. 2.Institute of Hematology and Blood TransfusionTbilisiUSSR

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