Cytogenetic Disorders During Tumor Progression in Leukemia

  • A. G. Zedginidze
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 35)


The successes in studying the karyotype of malignant tumors as well as the achievements in molecular biology and molecular genetics have considerably deepened our knowledge concerning the role of chromosomal disorders in oncogenesis [1–4]. Recognition of clonal origin of leukemias [5] has stimulated the interest in studying the formation and development of cytogenetically marked leukemic clones during development of leukemias.


Acute Lymphocytic Leukemia Chronic Myeloid Leukemia Acute Leukemia Chromosome Aberration Clonal Origin 
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    Rowley JD (1983) Human oncogene locations and chromosome aberrations. Nature 301:290–291PubMedCrossRefGoogle Scholar
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    Sandberg A (1983) A chromosomal hypothesis of oncogenesis. Cancer Genet Cytogenet 8(4):277–285PubMedCrossRefGoogle Scholar
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    Worobjow AI (1965) Voprosi klonowoi theori leikosov (in Russian). Probl Gematol 2:14–25Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • A. G. Zedginidze
    • 1
  1. 1.Georgian Research Institute of Hematology and Blood TransfusionTbilisiUSSR

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