Abstract
Various test systems are known in Drosophila melanogaster for the detection of the different types of mutations. One of the most frequently used mutagenicity test systems detects sex-linked recessive lethals (SLRL). With this test any point mutation or chromosome aberration occurring on the X chromosome which is lethal in hemizygous condition can be detected. The test takes two generations because it is restricted to the detection of the mutations induced in the X chromosome only. One takes advantage of the fact that the recessive lethals manifest themselves in hemizygous (XY) males, but are not expressed in heterozygous females and can be transmitted to the next generation. The “Muller-5” or “Basc” method (see Figure 21) makes use of a so-called “balancer chromosome” which carries two inversions as well as the dominant marker Bar (B, bar eyes) and the recessive marker white-apricot (wa, apricot eyes).
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Graf, U., van Schaik, N., Würgler, F.E. (1992). Mutation Genetics. In: Drosophila Genetics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76805-7_5
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DOI: https://doi.org/10.1007/978-3-642-76805-7_5
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