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Wirksamkeit und therapeutische Relevanz von Nimodipin bei primär degenerativer Demenz und Multiinfarkt-Demenz

  • W. M. Herrmann
  • K. Stephan
Conference paper

Zusammenfassung

Die noch immer verbreitete Skepsis gegenüber dem therapeutischen Nutzen von Arzneimitteln bei der Behandlung seniler Demenzen rührt teilweise allein daher, daß bei einem großen Teil der bislang durchgeführten klinischen Prüfungen Patienten mit eher unspezifischen Einschlußdiagnosen teilnahmen. Meist handelte es sich dabei um die Diagnose hirnorganisches Psychosyndrom.

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Literatur

  1. Abt K (1983) Significance testing of many variables. Neuropsychobiology 9:47–51PubMedCrossRefGoogle Scholar
  2. Abt K (1987) Descriptive data analysis: a concept between confirmatory and exploratory data analysis. Meth Inform Med 26:77–88PubMedGoogle Scholar
  3. Amaducci L, Angst J, Bech P et al. (1990) Consensus Conference on the Methodology of Clinical Trials of „Nootropics“, Munich, June 1989. Report of the Consensus Committee. Pharmacopsychiatry 23:171–175Google Scholar
  4. Bergener M (1989) Future of psychogeriatrics: a multidisciplinary approach with applications for clinical practice. In: Bergener M, Reisberg B (eds) Diagnosis and treatment of senile dementia. Springer, Berlin Heidelberg New York Tokyo, pp 3–13Google Scholar
  5. Brenner RP, Ulrich RF, Spiker DG, Sclabassi RJ, Reynolds III CF, Marin RS, Boiler F (1986) Computerized eeg spectral analysis in elderly normal, demented and depressed subjects. Electroencephalogr Clin Neurophysiol 64:483–492PubMedCrossRefGoogle Scholar
  6. Buchwald JS, Erwin RJ, Read S, Lancker D van, Cummings JL (1989) Midlatency auditory evoked responses: differential abnormality of P1 in Alzheimer’s disease. Electroencephalogr Clin Neurophysiol 74:378–384PubMedCrossRefGoogle Scholar
  7. CIPS Collegium Internationale Psychiatriae Scalarum (1981/86) Internationale Skalen für Psychiatrie, 2./3. Aufl. Beltz, WeinheimGoogle Scholar
  8. Coben LA, Danziger WL, Berg L (1983) Frequency analysis of the resting awake EEG in mild senile dementia of Alzheimer type. Electroencephalogr Clin Neurophysiol 55:372–380PubMedCrossRefGoogle Scholar
  9. Coben LA, Danziger W, Storandt M (1985) A longitudinal EEG study of mild senile dementia of Alzheimer type: changes at 1 year and 2.5 years. Electroencephalogr Clin Neurophysiol 61:101–112PubMedCrossRefGoogle Scholar
  10. Coper H, Kanowski S (1976) Wirken Geriatrika? Arzneimittelforsch 26:1027–1028PubMedGoogle Scholar
  11. Coper H, Herrmann WM, Woite A (1987) Psychostimulantien - Analeptika - Nootropika: Versuch einer Differenzierung von Arzneimitteln zur Behandlung von Hirnlei- stungsstörungen. Dtsch Ärztebl 84(7):B271–274Google Scholar
  12. Drachman DA (1989) Risk vs. benefit. Paper presented at the FDA’s Antidementia Drug Assessment Symposium, Rockville, Md. - Transcript: Department of Health and Human Services. Public, Health Service, Food and Drug Administration, Peripheral and Central Nervous System Drugs Advisory Panel, Antidementia Drug Assessment Symposium, vol II. Miller Reporting Co., Washington D.C., pp 157–172Google Scholar
  13. Erkinjuntti T (1987) Differential diagnosis between Alzheimer’s disease and vascular dementia: evaluation of common clinical methods. Acta Neurol Scand 76:433–442PubMedCrossRefGoogle Scholar
  14. Erkinjuntti T, Ketonen L, Sulkava R, Vuorialho M, Palo J (1987) CT in the differential diagnosis between Alzheimer’s disease and vascular dementia. Acta Neurol Scand 75:262–270PubMedCrossRefGoogle Scholar
  15. Erzigkeit H (1986) Der Syndrom-Kurztest zur Erfassung von Aufmerksamkeits- und Gedächtnisstörungen. Vless, VaterstettenGoogle Scholar
  16. Fischhof P, Wagner G, Littschauer L et al. (1989) Therapeutic results with nimodipine in primary degenerative dementia and multi-infarct dementia. In: Bergener M, Reisberg B (eds) Diagnosis and treatment of senile dementia. Springer, Berlin Heidelberg New York Tokyo, pp 350–359Google Scholar
  17. Folstein MF, Folstein SE, McHugh PR (1975) „Mini-Mental State“: a practical method for grading the cognitive state of patients for the clinician. J Psychiat Res 12:189–198PubMedCrossRefGoogle Scholar
  18. Hachinsky VC, Iliff LD, Zilhka E et al. (1975) Cerebral blood flow in dementia. Arch Neurol 32:632–637CrossRefGoogle Scholar
  19. Herrmann WM, Stephan K (1991a) Geriatrika/Nootropika. In: Oswald WD, Herrmann WM, Kanowski S, Lehr UM, Thomae H (Hrsg) Gerontologie, 2. Aufl. Kohlhammer, Stuttgart, S 186–196Google Scholar
  20. Herrmann WM, Stephan K (1991b) Efficacy and clinical relevance of cognition enhancers. Alzheimer Dis Assoc Disord 5, Suppl 1:S 7–12Google Scholar
  21. Kanowski S, Fischhof P, Hiersemenzel R, Röhmel J, Kern U (1988) Wirksamkeitsnachweis von Nootropika am Beispiel von Nimodipin - ein Beitrag zur Entwicklung geeigneter klinischer Prüfmodelle. Z Gerontopsychol Gerontopsychiat 1:35–44Google Scholar
  22. Kanowski S, Ladurner G, Maurer K, Oswald WD, Stein U (1990) Empfehlungen zur Evaluierung der Wirksamkeit von Nootropika. Z Gerontopsychol Gerontopsychiat 3:67–79Google Scholar
  23. Langley MS, Sorkin EM (1989) Nimodipine: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in cerebrovascular disease. Drugs 37:669–699PubMedCrossRefGoogle Scholar
  24. Matecjek M, Blasowitsch R, Schweingruber M, Abt K (1986) Some correlations in geriatric patients between EEG parameters and clinical status as evaluated using the observer-rated SCAG rating scale. A retrospective study. Neuropsychobiology 15:49–56CrossRefGoogle Scholar
  25. Prinz PN, Vitiello MV (1989) Dominant accipital (alpha) rhythm frequency in early stage Alzheimer’s disease and depression. Electroencephalogr Clin Neurophysiol 73:428–432Google Scholar
  26. Reisberg B, Ferris SH, DeLeon MJ, Crook T (1982) The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry 139:1136–1139PubMedGoogle Scholar
  27. Shader RJ, Harmatz JS, Salzman C (1974) A new scale for clinical assessment on geriatric populations: Sandoz Clinical Assessment - Geriatric. J Am Geriat Soc 22:107–113PubMedGoogle Scholar
  28. Streitberg B, Röhmel J (1984) Exact nonparametrics in APL. In: APL Conference 1984, Helsinki. ACM, New York, pp 313–325Google Scholar
  29. Traber J, Gispen WH (eds) (1989) Nimodipine and central nervous system function: New Vistas. Schattauer, StuttgartGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • W. M. Herrmann
  • K. Stephan

There are no affiliations available

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