Zusammenfassung
Nachdem am Bonner Hämophilie-Zentrum seit Juni 1984 ausschließlich Virusinaktivierte Gerinnungsfaktor-Präparate verwendet wurden, traten nur 1985 noch einmal zwei HIV-Serokonversionen nach Verwendung von trocken- bzw. mit Heptan erhitzten Faktor VIII-Präparaten auf. Seitdem kamen unter den z.Zt. betreuten 391 HIV-seronegativen Hämophilen keine Serokonversionen mehr vor.
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Literatur
Cuthbert RJG, Ludlam CA, Rebus S, Peutherer JF, Aw DWJ, Beatson D, Steel CM, Reynolds B (1989) Human immunodeficiency virus detection: correlation with clinical progression in the Edinburgh haemophiliac cohort. Brit J Haematol 72:387–390
Cuthbert RJG, Ludlam C, Tucker J, Steel CM, Beatson D, Rebus S, Peutherer JF (1990) Five year prospective study of HIV infection in the Edinburgh haemophiliac cohort. Brit Med J 301:956–961
Kleim J-P, Bailly E, Schneweis KE, Brackmann HH, Hammerstein U, Hanfland P, van Loo B, Oldenburg J (1990) Acute HIV-1 infection in patients with hemophilia B treated with ß-propiolactone-UV-inactivated clotting factor. Thrombosis and Haemostasis 64:336–337
Kleim J-P, Ackermann A, Brackmann HH, Gahr M, Schneweis KE (1991) Epidemiologically closely related viruses from hemophilia B patients display high homology in two hypervariable regions of the HIV-1 env gene. AIDS Res Human Retroviruses 7:417–421
Ludlam CA, Steel CM, Cheingsong-Popov R, McClelland DBL, Tucker J, Tedder RS, Weiss RA, Philp I (1985) Human T-lymphotropic virus type III (HTLV-III) infection in seronegative haemophiliacs after transfusion of factor VIII. Lancet ii: 233–236
Peutherer JF, Rebus S, Barr P, Ludlam CA, Watson HG, Steel MC (1990) Confirmation of non-infection in persistently HIV-seronegative recipients of contaminated factor VIII. Lancet ii: 1008
Schneweis KE, Ackermann A, Friedrich A, Kleim J-P, Kornau K, Ruff R, Siefer-Wippermann B (1989) Comparison of different methods for detecting human immune deficiency virus in human immunodeficiency virus-seropositive hemophiliacs. J Med Virol 29:94–101
Schneweis KE, Kleim J-P, Bailly E, Niese D, Wagner N, Brackmann HH (1990) Graded cytopathogenicity of the human immunodeficiency virus (HIV) in the course of HIV infection. Med Microbiol Immunol 179:193–203
Simmonds P, Lainson FAL, Cuthbert R, Steel CM, Peutherer JF, Ludlam CA (1988) HIV antigen and antibody detection: variable responses to infection in the Edinburgh haemophiliac cohort. Brit Med J 296:593–598
Simmonds P, Balfe P, Peutherer JF, Ludlam CA, Bishop JO, Brown AJL (1990) Human immunodeficiency virus-infected individuals contain provirus in small numbers of peripheral mononuclear cells and at low numbers. J Virol 64:864–872
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© 1991 Springer-Verlag Berlin Heidelberg
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Schneweis, K.E. et al. (1991). HIV-Infektion bei Hämophilie B-Patienten nach Anwendung eines β-Propiolacton/UV-behandelten PPSB-Konzentrates. In: Landbeck, G., Scharrer, I., Schramm, W. (eds) 21. Hämophilie-Symposion. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76764-7_8
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