Zusammenfassung
Aufgrund der Nukleinsäuren-Sequenzanalyse sind die bisher charakterisierten SIV-Isolate, dem menschlichen HIV-2 ähnlicher als dem HIV-1. Zu diesen als SIV-2 zusammengefaßten Viren gehören die aus der afrikanischen grünen Meerkatze [1], Rhesusaffe [2], Mangabe [3] und Mandrill [4]. Die Untersuchungen der verschiedenen Affen zeigte, daß die Verbreitung von SIV-2 in Afrika wesentlich weitflächiger ist als die Durchseuchung der Menschen mit HIV-2.
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Literatur
Kanki PJ, Alrov J, Essex M (1985) Isolation of T-lymphotropic retrovirus related to HTLV-III/LAV from wild caught African Green Monkeys. Science 230:951–954
Chakrabarti L, Guyader M, Alizon M, Daniel MD, Desrosiers RC, Tiollais P, Sonigo P (1987) Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian retroviruses. Nature 328:543–547
Hirsch VM, Olmsted RA, Murphey-Corb M, Purcell RH, Johnson PR (1989) An African primate lentivirus (SIVsm) closely related to HIV-2. Nature 339:389–392
Tsujimoto H, Hasegawa A, Maki N, Fukasawa M, Miura T, Speidel S, Coopers RW, Moriyama EN, Gojobori T, Hayami M (1989) Sequence of a novel simian immunodeficiency virus from a wild-caught African mandrill. Nature 341:539–541
Huet T, Cheynier R, Meyerhans A, Roelants G, Wain-Hobson S (1990) Genetic organization of a chimpanze lentivirus related to HIV-1. Nature 345:356–359
Desrosiers RC (1990) HIV-1 origins: A finger on the missing link. Nature 345:288–289
Diamond JM (1988) Molecular evolution — DNA based phylogenies of the three chimpanzes. Nature 332:685–686
Smith TF, Srinivasan A, Schochetman G, Marcus M, Myers G (1988) The phylogenetic history of immunodeficiency viruses. Nature 333:573–575
Barré-Sinoussi F, Cherman JC, Rey F, Nugeybe MT, Chamaret S, Gruest J, Dauget C, Axler-Blin C, Brun-Vezinet F, Rozioux C, Rozenbaum W, Montagnier L (1983) Isolation of a T-lymphotropic retrovirus from a patient at risk of acquired immune deficiency syndrome (AIDS). Science 220:868–870
Huet T, Dazza MC, Brun-Vézinet F, Roelants GE, Wain-Hobson S (1989) A highly defective HIV-1 strain isolated from a healthy Gabonese individual presenting an atypical Western blot. AIDS 3:707–715
Dewhurst S, Embretson JE, Anderson DC, Mullins JI, Fultz PN (1990) Sequence analysis and acute pathogenicity of molecularly cloned SIVsmm-PBjl4. Nature 345:636–640
Aziz DC, Hanna Z, Jolicoeur P (1989) Severe immunodeficiency disease induced by a defective murine leukemia virus. Nature 338:505–508
Martin MM (1990) SIV Pathogenicity — Fast acting slow viruses. Nature 345:572–573
Vyakarnam A, McKeating J, Meager A, Beverley PC (1990) Tumor necrosis factors (α, β) induced by HIV-1 in peripheral blood mononuclear cells potentiate virus replication. AIDS 4:21–27
Bussolino F, Camussi G, Baglioni C (1988) Synthesis and release of platelet activating factor by human vascular endothelial cells treated with tumor necrosis factor or interleu-kin la. J Biol Chem 263:11856–11861
Wong-Staal F (1989) Molecular Biology of human immunodeficiency viruses. In: Current topics in AIDS, Vol. 2 pp 81–102, John Wiley, Chichester
Cuthbert RJG, Ludlam CA, Tucker J, Steel CM, Beatson D, Rebus S, Peutherer JF (1990) Five year prospective study of HIV infection in the Edinburgh haemophiliac cohort. Brit Med J 301:956–961
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© 1991 Springer-Verlag Berlin Heidelberg
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Gürtler, L.G. (1991). Aktuelle virologische Aspekte der HIV-Infektion. In: Landbeck, G., Scharrer, I., Schramm, W. (eds) 21. Hämophilie-Symposion. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76764-7_7
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DOI: https://doi.org/10.1007/978-3-642-76764-7_7
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