Abstract
We have previously reported on the isolation of a plastic adhesive variant, ESb-MP, derived from the suspension growing highly metastatic murine lymphoma ESb (1,2). Animals inoculated subcutanesously with ESb-MP cells developed large primary tumors and survived three to four times as long as animals inoculated with the non-adhesive ESb cells. The two lines were similar in expression of cell surface differentiation antigens and tumor antigens but differences could be seen in reactivity to certain lectins (2) and in expression of adhesion molecules. More information on cytogenetic aspects, changes in cell surface molecules, chemotactic responsiveness in vitro and of changes in the in vivo growth and organotropism will be reviewed.
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References
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© 1991 Springer-Verlag Berlin Heidelberg
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Schirrmacher, V., Kowitz, A., Kadmon, G., Benke, R., Altevogt, P. (1991). Change in metastasis and organotropism of mouse lymphoma variants associated with changes in expression of adhesion molecules and chemotactic responsiveness. In: Gabius, H.J., Gabius, S. (eds) Lectins and Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76739-5_12
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DOI: https://doi.org/10.1007/978-3-642-76739-5_12
Publisher Name: Springer, Berlin, Heidelberg
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