Abstract
Organ patterns of arterial metastatic involvement are different in patients with histories of upper and lower rectal carcinoma. Analyses of autopsy data (Weiss et al, 1981;1984) suggest that these patterns are partially imposed by the step-wise nature of metastasis. As shown in Figure 1, in upper rectal carcinomas, seeding mainly via the portal venous system results in secondary metastases in the liver; cells from these lesions seed tertiary lung lesions via the inferior vena cava, which in turn generalize via the arterial system to form widespread quaternary arterial metastases. In contrast, primary carcinomas of the lower rectum predominantly first generate secondary lung metastases via the systemic venous system, and these in turn generate tertiary arterial metastases in other organs. Both groups of primary tumors arose in a common site, the rectum; both groups were of the same histologic type (adenocarcinomas), both were of the same stage, and both used similar seeding routes from the lungs to generate the arterial metastases (Weiss, et al 1981, 1984).
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© 1991 Springer-Verlag Berlin Heidelberg
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Glaves, D., Weiss, L., Vidal-Vanaclocha, F. (1991). Site-associated differences in endogenous lectin expression by mouse colon carcinoma cells. In: Gabius, H.J., Gabius, S. (eds) Lectins and Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76739-5_10
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DOI: https://doi.org/10.1007/978-3-642-76739-5_10
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