Myocardial Dysfunction in Experimental Septic Shock

  • P. E. Krösl
  • J. P. Pretorius


The behavior of the heart in experimental shock models using slow or bolus infusion of endotoxin [26, 29, 30, 32, 44, 55, 79] or live bacteria [31, 61], splanchnic artery occlusion [45, 69] pancreatitis [8], or peritonitis [61, 68, 94] continues to be the subject of intense debate in the research community. The role of the heart in septic shock can be defined by answering the following questions:
  1. 1.

    Does the heart fail in septic shock and, if so, when does it fail?

  2. 2.

    Does the heart initiate cardiovascular collapse? Is the heart the primary target organ responsible for the development of cardiovascular failure during septic shock, or is it the peripheral circulation?

  3. 3.

    Does changed cardiac function during septic shock indicate myocardial dysfunction or is this due to complex functional adjustment of an otherwise “normal” heart to the altered milieu in which it is forced to contract?



Septic Shock Myocardial Dysfunction Circ Shock Aortic Occlusion Endotoxin Shock 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • P. E. Krösl
    • 1
  • J. P. Pretorius
    • 1
  1. 1.Ludwig Boltzmann Institute for Experimental and Clinical TraumatologyViennaAustria

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