Experimentally Induced DIC — DIC as a Cause of MOF

  • S. Bahrami
  • G. Schlag


Gram-negative septicemia remains a serious cause of mortality (Carrico et al. 1986) and is often associated with disseminated intravascular coagulation (DIC) (Effeney et al. 1978; Siegal et al. 1978; Spero et al. 1980; Edgington 1990; Linares 1990). Autopsy revealed sepsis and DIC in 74% of burn patients, while multiorgan failure (MOF) and DIC were encountered in 95% (Linares 1990), indicating a major role of DIC in the development of MOE DIC is a pathophysiological syndrome induced by trauma, endotoxemia, and especially septic shock. Changes in the clotting and complement system, activation of the fibrinolytic system and reduction of platelet counts during both gram-negative sepsis in humans and experimental endotoxin shock in other species are characteristics of DIC (Aasen et al. 1978 a, b, c; Garner and Evensen 1974; Garner et al. 1974; Hamilton et al. 1978; Müller-Berghaus 1975).


Tissue Factor Disseminate Intravascular Coagulation Disseminate Intravascular Coagulation Plasma Fibrinogen Level Circ Shock 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • S. Bahrami
    • 1
  • G. Schlag
    • 1
  1. 1.Ludwig Boltzmann Institute for Experimental and Clinical TraumatologyViennaAustria

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