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Experimentally Induced DIC — DIC as a Cause of MOF

  • S. Bahrami
  • G. Schlag

Abstract

Gram-negative septicemia remains a serious cause of mortality (Carrico et al. 1986) and is often associated with disseminated intravascular coagulation (DIC) (Effeney et al. 1978; Siegal et al. 1978; Spero et al. 1980; Edgington 1990; Linares 1990). Autopsy revealed sepsis and DIC in 74% of burn patients, while multiorgan failure (MOF) and DIC were encountered in 95% (Linares 1990), indicating a major role of DIC in the development of MOE DIC is a pathophysiological syndrome induced by trauma, endotoxemia, and especially septic shock. Changes in the clotting and complement system, activation of the fibrinolytic system and reduction of platelet counts during both gram-negative sepsis in humans and experimental endotoxin shock in other species are characteristics of DIC (Aasen et al. 1978 a, b, c; Garner and Evensen 1974; Garner et al. 1974; Hamilton et al. 1978; Müller-Berghaus 1975).

Keywords

Tissue Factor Disseminate Intravascular Coagulation Disseminate Intravascular Coagulation Plasma Fibrinogen Level Circ Shock 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aasen AO, Dale J, Ohlsson K, Gallimore MJ (1978a) Effects of slow intravenous administration of endotoxin on blood cells and coagulation in dogs. Eur Surg Res 10:194–205.PubMedGoogle Scholar
  2. Aasen AO, Ohlsson K, Larsbraaten M, Amundsen E (1978b) Changes in plasminogen levels, plasmin activity and activity of antiplasmins during endotoxin shock in dogs. Eur Surg Res 10:63–72.PubMedGoogle Scholar
  3. Aasen AO, Mellbye OJ, Ohlsson K (1978c) Complement activation during subsequent stages of canine endotoxin shock. Scand J Immunol 8:509–513.PubMedGoogle Scholar
  4. Abildgaard U (1969) Binding of thrombin to antithrombin III. Scand J Clin Lab Invest 24:23–27.PubMedGoogle Scholar
  5. Abildgaard U (1979) A review of antithrombin III. In: Collen D (ed) The physiological inhibitors of coagulation and fibrinolysis. Elsevier/North Holland, Amsterdam, pp 19–29.Google Scholar
  6. Aderka D (1991) Role of tumor necrosis factor in the pathogenesis of intravascular coagulopathy of sepsis: potential new therapeutic implications. Isr J Med Sci 27:52–60.PubMedGoogle Scholar
  7. Altieri DC, Morrissey JH, Edgington TS (1988) Adhesive receptor Mac-1 coordinates the activation of factor X on stimulated cells of monocytic and myeloid differentiation: an alternative initiation of the coagulation protease cascade. Proc Natl Acad Sci USA 85:7642–7466.Google Scholar
  8. Bahrami S, Paul E, Redl H, Schlag G (1989a) Therapeutic modalities to ameliorate endotoxin induced DIC in the rats. Prog Clin Biol Res 308:977–982.PubMedGoogle Scholar
  9. Bahrami S, Redl H, Schlag G (1989b) Beeinflussung der durch Endotoxin verursachten DIC in der Ratte mittels Heparin, Antithrombin III, Antithrombin III-Heparin-Komplex oder Hirudin. Anaesthesist 38 [Suppl]:311.Google Scholar
  10. Bahrami S, Redl H, Schlag G (1990) Protective effects of HWA 138 in endotoxin related coagulation disorders. Circ Shock 31:250.Google Scholar
  11. Bahrami S, Redl H, Buurman WA, Schlag G (1991a) Endotoxin shock related disorders induced by high-vs low-dose lipopolysaccharide (LPS) injection in rats. Eur Surg Res 23 [S1]:13.Google Scholar
  12. Bahrami S, Redl H, Schlag G, Leichtfried G, Ceska M, Strieter RM (1991b) Comparison of the efficacy of different xanthine dérivates to reduce endotoxin-induced mortality and/or cytokine production: in vivo and in vitro studies. Circ Shock 34:140.Google Scholar
  13. Bahrami S, Redl H, Leichtfried G, Kober C, Wilfing C, Schlag G (1991c) Beneficial effects of anti-TNF monoclonal antibody (mAB) in endotoxin-induced coagulation disorder in rats. Circ Shock 34:167.Google Scholar
  14. Bahrami S, Redl H, Buurman WA, Schlag G (1992) Influence of the xanthine derivate HWA 138 on endotoxin-related coagulation disturbances: Effects in non-sensitized vs D-galactosamine sensitized rats. Thromb Haemost 68:418–423.PubMedGoogle Scholar
  15. Barroso-Aranda J, Schmid-Schönbein GW (1989) Pentoxifylline pretreatment decreases the degree of neutrophil activation during endotoxin shock and improves survival. Workshop pentoxifylline and analogues: effects on leukocyte function. Le Mas d’Artigny, p 27.Google Scholar
  16. Baruch D, Lindhout T, Wagenvoord R, Hemker HC (1986) Inhibition of thrombin catalyzed reactions in blood coagulation and platelet activating by heparin fractions in the absence of antithrombin III. Haemostasis 16:71–81.PubMedGoogle Scholar
  17. Beretz A, Archipoff G, Camilla C, Brisson C, Klein-Soyer C, Freyssinet JM, Cazenave JP (1989) Leuko-cyte-endothelium interactions and thrombosis: effects. of pentoxifylline. Workshop pentoxifylline and analogues: effects on leukocyte function. Le Mas d’Artigny, p 14.Google Scholar
  18. Berg JT, Smith RM (1985) Endotoxin protection of rats from pulmonary oxygen toxicity: lack of complement involvement. Res Commun Chem Pathol Pharmacol 47:309–312.PubMedGoogle Scholar
  19. Beutler B, Cerami A (1986) Cachectin and tumor necrosis factor as two sides of the same biological coin. Nature 320:584–588.PubMedGoogle Scholar
  20. Bevilacqua MP, Gimbrone MA (1987) Inducible en-dothelial functions in inflammation and coagulation. Semin Thromb Hemost 13:425–433.PubMedGoogle Scholar
  21. Bick RL, Dukes ML, Wilson WL, Fekete LF (1977) Antithrombin III (AT-III) as a diagnostic aid in disseminated intravascular coagulation. Thromb Res 10: 721–729.PubMedGoogle Scholar
  22. Bick RL, Bick MD, Feketa LF (1980) Antithrombin III patterns in disseminated intravascular coagulation. Am J Clin Pathol 73:577–583.PubMedGoogle Scholar
  23. Blauhut B, Necek S, Kramar H, Vinazzer H, Bergmann H (1980) Activity of antithrombin III and effect of heparin on coagulation in shock. Thromb Res 196:775–782.Google Scholar
  24. Blauhut B, Kramar H, Vinazzer H, Bergmann H (1985) Substitution of antithrombin III in shock and DIC: a randomized study. Thromb Res 39:81–89.PubMedGoogle Scholar
  25. Booyse FM, Osikowicz G, Feder S, Scheinbuks J (1984) Isolation and characterization of a urokinase-type plasminogen activator (Mr = 54,000) from cultured human endothelial cells indistinguishable from urinary urokinase. J Biol Chem 259:7138–7143.Google Scholar
  26. Brown DL (1975) Complement and coagulation. Br J Haematol 30:377.PubMedGoogle Scholar
  27. Büller HR, Bolwerk C, Cate T, Roos J, Kahle LH, Ten-Cate JW (1982) Postoperative hemostatic profile in relation to gram negative septicemia. Crit Care Med 10:311–315.PubMedGoogle Scholar
  28. Carrico CJ, Meakins JL, Marshall JC, Fry D, Maier RV (1986) Multiple organ failure syndrome. Arch Surg 121:196–208.PubMedGoogle Scholar
  29. Chalkiadakis GE, Kostakis A, Karayannakos PE, Chalkiadakis ME, Sgouromali S, Giamarellou H, Skalkeas GD (1985) Pentoxifylline in the treatment of experimental peritonitis in rats. Arch Surg 120:1141–1144.PubMedGoogle Scholar
  30. Colucci M, Balconi R, Lorenzet R, Pietra A, Locati D, Donati MB, Semararo N (1983) Cultured human endothelial cells generate tissue factor in response to endotoxin. J Clin Invest 71:1893–1897.PubMedGoogle Scholar
  31. Colucci M, Paramo JA, Collen D (1985) Generation in plasma of a fastacting inhibitor of plasminogen activator in response to endotoxin stimulation. J Clin Invest 75:818–824.PubMedGoogle Scholar
  32. Coccia MT, Waxman K, Soliman MH, Tominaga G, Piderski L (1989) Pentoxifylline improves survival following hemorrhagic shock. Crit Care Med 17:36–38.PubMedGoogle Scholar
  33. Corrigan JJ (1971) Effect of heparin on endotoxin-induced thrombocytopenia. Proc Soc Exp Biol Med 136:124.PubMedGoogle Scholar
  34. Day KC, Hoffman LC, Palmier MO, Kretzmer KK, Huang MD, Pyla EY, Spokas E, Broze GJ, Warren TG, Wun TC (1990) Recombinant lipoprotein associated coagulation inhibitor inhibits tissue throm-boplastin induced intravascular coagulation in the rabbit. Blood 76:1538–1545.PubMedGoogle Scholar
  35. DeProst D, Ollivier V, Hamkim J (1989) Pentoxifylline inhibition of the generation of procoagulant activity by activated mononuclear phagocytes. Workshop pentoxifylline and analogues: effects on leukocyte function. Le Mas d’Artigny, p 10-11.Google Scholar
  36. Des Prez RM (1964) Effects of bacterial endotoxin on rabbit platelets. III. Comparison of platelet injury induced by thrombin and by endotoxin. J Exp Med 120:305.Google Scholar
  37. Edgington TS (1990) Pathogenetic linkages between gram negative septic shock and the cellular initiation and regulation of coagulation. In: Schlag G, Redl H, Siegel JH, Traber D (eds) Shock, sepsis, and organ failure. 2nd Wiggers Bernard Conference. Springer, Berlin Heidelberg New York, pp 351–367.Google Scholar
  38. Effeney DJ, Blaisdell FW, Mclntyre KE (1978) The relationship between sepsis and disseminated intravascular coagulation. J Trauma 18:689–695.PubMedGoogle Scholar
  39. Emerson TE (1987) Effects of purified fibronectin alone and combined with immunoglobulin G or Antithrombin III on survival during gram negative peritonitis or endotoxemia in rats. J Trauma 27:1261–1266.PubMedGoogle Scholar
  40. Emerson TE, Fournel MA, Leach WJ, Redens TB (1987a) Protection against disseminated intravascular coagulation and death by antithrombin III in the Escherichia coli endotexmic rat. Circ Shock 21:1–13.PubMedGoogle Scholar
  41. Emerson TE, Redens TB, Collins MS (1987b) Antithrombin-III protects against disseminated intravascular coagulation (DIC) in Klebsiella peritonitis. Clin Res 35:143A.Google Scholar
  42. Emerson TE, Fournel MA, Redens TB, Taylor FB (1989) Efficacy of antithrombin III supplementation in animal models of fulminant Escherichia coli endotoxemia or bacteremia. Am J Med 87:27S–33S.PubMedGoogle Scholar
  43. Esmon CT, Esmon NL, Harris K (1982) Complex formation between thrombin and thrombomodulin inhibits both thrombin catalyzed fibrin formation and factor V activation. J Biol Chem 257:7944–4947.PubMedGoogle Scholar
  44. Esmon NL (1987) Thrombomodulin. Semin Thromb Hemost 13:454–463.PubMedGoogle Scholar
  45. Freudenberg N (1978) Endothelium and shock. Pathol Res Pract 162:105.PubMedGoogle Scholar
  46. Gans H, Krivit W (1960) Effect of endotoxin shock on the clotting mechanism of dogs. Ann Surg 152:69–76.PubMedGoogle Scholar
  47. Gans H, Krivit W (1961) Effect of endotoxin shock on the clotting mechanisms of dogs. Ann Surg 153:453–458.PubMedGoogle Scholar
  48. Garner R, Evensen SA (1974) Endotoxin-induced intravascular coagulation and shock in dogs. The role of factor VII. Br J Haematol 27:655–668.PubMedGoogle Scholar
  49. Garner R, Chater BV, Brown DL (1974) The role of complement in endotoxin shock and disseminated intravascular coagulation. Experimental observations in the dog. Br J Haematol 28:293–401.Google Scholar
  50. Gewurz H, Shin HS, Mergenhagen SE (1968) Interaction of the complement system with endotoxic lipopoly-saccharide. Consumption of each of the six terminal complement components. J Exp Med 128:1049–1057.PubMedGoogle Scholar
  51. Gillis CN, Pitt BR (1982) The fate of circulating amines within the pulmonary circulation. Annu Rev Physiol 44:269–274.PubMedGoogle Scholar
  52. Gomez C, Paramo JA, Colucci M, Rocha E (1989) Effect of heparin and or antithrombin III on the generation of endotoxin induced plasminogen activator inhibitor. Thromb Haemost 62:694–698.PubMedGoogle Scholar
  53. Grossman J, Pohlman T, Koerner F, Mosher D (1983) Plasma fibronectin concentration in animal models of sepsis and endotoxemia. J Surg Res 34:145–150.PubMedGoogle Scholar
  54. Hagen FS, Gray CL, O’Hara P, Grant FJ, Saari GC, Woodbury RG, Hart CE, Insley M, Kisiel W, Kurachi K, Davie EW (1986) Characterization of a cDNA coding for human factor VII. Proc Natl Acad Sci USA 83:2412–2416.PubMedGoogle Scholar
  55. Hamilton PJ, Stalker AL, Douglas AS (1978) Disseminated intravascular coagulation: a review. J Clin Pathol 31:609–619.PubMedGoogle Scholar
  56. Harada H, Ishizaka Y, Yonemaru M, Mallick AA, Hatherill JR, Zheng H, Lilly CM, O’Hanley PT, Raffin TA (1989) The effects of aminophylline and pentoxifylline on multiple organ damage after Escherichia coli sepsis. Am Rev Respir Dis 140:974–980.PubMedGoogle Scholar
  57. Hardaway RM, Johnson D (1963) Clotting mechanisms in endotoxin shock. Arch Intern Med 112:189–196.Google Scholar
  58. Hardaway RM, Husni EA, Geever EF, Noyes HE, Burns JW (1961) Endotoxin Shock. A manifestation of intravascular coagulation. Ann Surg 154:791–802.PubMedGoogle Scholar
  59. Hauptman JG, Hassouna HI, Bell TG, Penner JA, Emerson TE (1988) Efficacy of antithrombin III in endotoxin-induced disseminated intravascular coagulation. Circ Shock 25:111–122.PubMedGoogle Scholar
  60. Hiller E, Saal IG, Ostendorf P, Griffiths GW (1977) The procoagulant activity of human granulocytes, lymphocytes and monocytes stimulated by endotoxin. Klin Wochenschr 55:751–757.PubMedGoogle Scholar
  61. Holm HA, Abilgaard U, Larsen MI, Kalvenes S (1987) Monitoring of heparin therapy: should heparin assays also reflect the patients antithrombin concentration? Thromb Res 46:669–675.PubMedGoogle Scholar
  62. Ishikawa A, Hafter R, Seemüller U, Gokel JM, Graeff H (1980) The effect of hirudin on endotoxin induced disseminated intravascular coagulation (DIC). Thromb Res 19:351–358.PubMedGoogle Scholar
  63. Ishizaka A, Wu Z, Stephens KE, Harada H, Hogue RS, O’Hanley PT, Raffin TA (1988) Attenuation of acute lung injury in septic guinea pigs by pentoxifylline. Am Rev Respir Dis 138:376–382.PubMedGoogle Scholar
  64. Kadish JL, Butterfield CE, Folkman J (1979) The effect of fibrin on cultured vascular endothelial cells. Tissue Cell 11:99–104.PubMedGoogle Scholar
  65. Klein HG, Bell WR (1974) Disseminated intravascular coagulation during heparin therapy. Ann Intern Med 80:477.PubMedGoogle Scholar
  66. Kneidinger R, Paul E, Redl H, Schlag G (1991) Comparison of different xanthine derivates on monocyte and granulocyte function in vitro. Circ Shock 34:141–142.Google Scholar
  67. Laposata M, Dovnarsky DK, Shin HS (1983) Thrombin-induced gap formation in confluent endothelial cell monolayers in vitro. Blood 62:549–556.PubMedGoogle Scholar
  68. Lerner RG, Goldstein R, Cummings G (1977) Endotoxin-induced disseminated intravascular clotting: evidence that it is mediated by neutrophil production of tissue factor. Thromb Res 11:253–261.PubMedGoogle Scholar
  69. Linares HA (1990) Sepsis, disseminated intravascular coagulation and multiorgan failure: catastrophic events in severe burns. In: Schlag G, Redl H, Siegel JH, Traber D (eds) Shock, sepsis, and organ failure. 2nd Wiggers Bernard Conference. Springer, Berlin Heidelberg New York, pp 370–396.Google Scholar
  70. Loskutoff DJ, Edgington TS (1977) Synthesis of a fibrinolytic activator and inhibitor by endothelial cells. Proc Natl Acad Sci USA 74:3903–3905.PubMedGoogle Scholar
  71. Lüscher EF (1975) The activation of intravascular coagulation by endotoxin. In: Urbaschek R, Urbaschek B, Neter E (eds) Gram-negative bacterial infections and mode of endotoxin actions. Springer, Berlin Heidelberg New York, pp 357–361.Google Scholar
  72. Machovich R (1988) Biology of endothelial cells. In: Machovich R (ed) Blood vessel wall and thrombosis, vol 1. CRC Press, Florida, pp 115–140.Google Scholar
  73. Madden RM, Ward M, Marlar R (1989) Protein C activity levels in endotoxin induced disseminated intravascular coagulation in a dog model. Thromb Res 55:297–307.PubMedGoogle Scholar
  74. Malik AB, Burgess CJ (1988) Mediators of lung vascular injury and edema after thrombin. Appl Cardiopul Pathophys 2:5–11.Google Scholar
  75. Malik AB, Powers MR, Lum H, Shepard JM, Siflinger-Birnboim A (1988) Endothelial monolayer permeability. Appl Cardiopul Pathophys 2:131–140.Google Scholar
  76. Mant MJ, King EG (1979) Servere, acute disseminated intravascular coagulation, a reappraisal of its patho-physiology, clinical significance and therapy based on 47 patients. Am J Med 57:557–563.Google Scholar
  77. Marbet GA, Griffith MJ (1986) Tissue thromboplastin induced reversible DIC and heparin-enhanced inhibitors in dogs. Thromb Haemost 55:78–85.PubMedGoogle Scholar
  78. Markwardt F (1956) Die antagonistische Wirkung der Hirudins gegen Thrombin in vivo. Naturwissenschaften 43:111.Google Scholar
  79. Markwardt F (1989) Development of hirudin as an anti-thrombotic agent. Semin Thromb Hemost 15:269–282.PubMedGoogle Scholar
  80. Miyashima T, Hayashi K, Awai M (1989) Initiation and recovery processes of endotoxin induced disseminated intravascular coagulation (DIC): scanning and transmission electron microscopic observations of rat renal tissues. Acta Med Okayama 43:115–126.PubMedGoogle Scholar
  81. Moore FD, Moss NA, Revhaug A, Wilmore D, Mannick JA, Rodrick ML (1987) A single dose of endotoxin activates neutrophils without activating complement. Surgery 102:200–205.PubMedGoogle Scholar
  82. Moore JN, Cook JA, Morris DD, Halushka PV, Wise WC (1990) Endotoxin-induced procoagulant activity, eicosanoid synthesis, and tumor necrosis factor production by rat peritoneal macrophages: effect of endotoxin tolerance and glucan. Circ Shock 31:281–295.PubMedGoogle Scholar
  83. Morrison DC, Ryan JL (1987) Endotoxins and disease mechanisms. Annu Rev Med 38:417–432.PubMedGoogle Scholar
  84. Müller R (1985) On the therapy of disturbances of blood fluidity. Angiology 36:226–634.Google Scholar
  85. Müller-Berghaus G (1975) Trigger Mechanism of endotoxin-induced intravascular coagulation. In: Ur-bascheck R, Urbaschek B, Neter E (eds) Gram-negative bacterial infections and mode of endotoxin actions. Springer, Berlin Heidelberg New York, pp 362–366.Google Scholar
  86. Müller-Berghaus G (1977) Beziehungen zwischen Komplement und Blutgerinnung. Klin Wochenschr 55:463.Google Scholar
  87. Müller-Berghaus G, Lasch HG (1975) Consumption coagulopathy in the course of endotoxinemia. In: Urbaschek R, Urbaschek B, Neter E (eds) Gram-negative bacterial infections and mode of endotoxin actions. Springer, Berlin Heidelberg New York, pp 353–356.Google Scholar
  88. Müller-Berghaus G, Bohn E, Höbel W (1976) Activation of intravascular coagulation by endotoxin: the significance of granulocytes and platelets. Br J Haematol 33:213–220.PubMedGoogle Scholar
  89. Müller-Berghaus G, Niepoth M, Rabens-Alles B, Rump E, Murano G (1985) Normal antithrombin III activity and concentration in experimental disseminated intravascular coagulation. Scan J Clin Lab Invest 45 [Suppl 178]:107–113.Google Scholar
  90. Nawroth PP, Stern DM (1986) Implication of thrombin formation on the endothelial cell surface. Semin Thromb Hemost 12:197–199.PubMedGoogle Scholar
  91. Nawroth PP, Kisiel W, Stern DM (1985) The role of en-dothelium in the hemostatic balance of haemostasis. Clin Haematol 14:531–546.PubMedGoogle Scholar
  92. Nemerson Y, Bach R (1982) Tissue factor revisited. Prog Hemost Thromb 6:237–261.PubMedGoogle Scholar
  93. Nemerson Y, Gentry R (1986) An ordered addition, essential activation model of the tissue factor pathway of coagulation: evidence for a conformational cage. Biochemistry 25:4020–4033.PubMedGoogle Scholar
  94. Nowak G, Markwardt F (1980) Influence of hirudin on endotoxin-induced disseminated intravascular coagulation (DIC) in weaned pigs. Exp Pathol 18:438–443.Google Scholar
  95. Osterud B (1979) The role of endothelial cells and suben-dothelial components in the initiation of blood coagulation. Haemostasis 8:324–331.PubMedGoogle Scholar
  96. Osterud B, Flaegstad T (1983) Increased thromboplastin activity in monocytes of patients with meningococcal infection: related to an unfavorable prognosis. Thromb Res 49:5.Google Scholar
  97. Osterud B, Rapaport SI (1977) Activation of factor IX by the reaction product of tissue factor and factor VII. Additional pathway for initiating blood coagulation. Proc Natl Acad Sci USA 74:5260–5264.PubMedGoogle Scholar
  98. Osterud B, Olsen JO, Tindall A (1985) The generalized Shwartzman reaction: effects of a glucocorticoid and endotoxin on thromboplastin synthesis by monocytes. In: van Furth R (ed) Mononuclear phagocytes. Nijhoff, Boston, p 705.Google Scholar
  99. Plow F, Edgington TS (1975) An alternative pathway for fibrinolysis. J Clin Invest 56:30–38.PubMedGoogle Scholar
  100. Pohlman TH, Stanness KA, Beatty PG, Ochs HD, Harlan JM (1986) An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin 1, and tumor necrosis factor-alpha increases neutrophil adherence by a CDw18-dependent mechanism. J Immunol 136:4548–4553.PubMedGoogle Scholar
  101. Prydz H, Pettersen KS (1988) Synthesis of thromboplastin (tissue factor) by endothelial cells. Hemostasis 18:215–223.Google Scholar
  102. Rapaport SI (1989) Inhibition of factor Vila/tissue factor-induced blood coagulation: with particular emphasis upon a factor Xa-dependent inhibitory mechanism. Blood 73:359–365.PubMedGoogle Scholar
  103. Ratnoff OD, Naff GB (1967) The conversion of C’1 s to C’1 esterase by plasmin and trypsin. J Exp Med 125:337–358.PubMedGoogle Scholar
  104. Rivers RPA, Hathaway WE, Weston WL (1975) The endotoxin-induced coagulant activity of human monocytes. Br J Haematol 30:311.PubMedGoogle Scholar
  105. Robinson AJ, Rapaport SI, Brown SF (1978) Pro-coagulant activity of peritoneal leukocytes: effects of cortisone and endotoxin. Am J Physiol 235:H333.PubMedGoogle Scholar
  106. Roka L, Bleyl H (1983) Equilibrium of the reaction of thrombin with antithrombin III. In: Wenzel E (ed) Antithrombin III: biochemistry, function, assay, and clinical significance. Ermer, Homburg, pp 45–46.Google Scholar
  107. Rosenberg RD (1974) The effect of heparin on factor XIa and plasmin. Thromb Diath Haemorrh 33:51.Google Scholar
  108. Ryan JW, Ryan US, Schultz DR, Whitaker C, Chung A (1975) Subcellular localisation of pulmonary angiotensin-converting enzyme (Kininase II). Biochem J 146:497–499.PubMedGoogle Scholar
  109. Sander GE, Huggins CG (1971) Subcellular localisation of angiotensin I converting enzyme in the rabbit lung. Nature 220:27–29.Google Scholar
  110. Schade UF (1990) Pentoxifylline increases survival in murine endotoxin shock and decreases formation of tumor necrosis factor. Circ Shock 31:171–181.PubMedGoogle Scholar
  111. Schaeffer RC, Barnhart MI, Carlson RW (1987) Pulmonary fibrin deposition and increased microvascular permeability to protein following fibrin microembolism in dogs: a structure-function relationship. Microvasc Res 33:327–352.PubMedGoogle Scholar
  112. Schipper HG, Jenkins CSP, Kahle LH (1978) Antithrombin-III transfusion in disseminated intravascular coagulation. Lancet 1:854.PubMedGoogle Scholar
  113. Schlag G, Redl H (1990) Endothelium as the interface between blood and organ in the evolution of organ failure. In: Schlag G, Redl H, Siegel JH (eds) Shock, sepsis, and organ failure. Springer, Berlin Heidelberg New York, pp 210–271.Google Scholar
  114. Schlag G, Redl H, Davies J (1991) TNF-antibodies (CB006) in a subchronic septic model in baboons to prevent multi-organ failure. Circ Shock 34:164–165.Google Scholar
  115. Schoendorf TH, Rosenberg M, Beller FK (1971) Endotoxin-induced disseminated intravascular coagulation in nonpregnant rats. A new experimental model. Am J Pathol 65:51–58.PubMedGoogle Scholar
  116. Schorer AE, Rick PD, Swaim WR, Moldow CF (1985) Structural features of endotoxin required for stimulation of endothelial cell tissue factor production. Exposure of preformed tissue factor after oxidant-mediated endothelial cell injury. J Lab Clin Med 106:38–42.PubMedGoogle Scholar
  117. Siegal T, Seligsohn U, Aghai E, Modan M (1978) Clinical and laboratory aspects of disseminated intravascular coagulation (DIC): a study of 118 cases. Thromb Haemost 39:122–134.PubMedGoogle Scholar
  118. Silverman RE, Cohen Z, Craig M, Wakefield A, Kim P, Langer B, Levy G (1989) Monocyte/macrophage procoagulant activity as a measure of immune responsiveness in Lewis and brown Norway inbred rats. Discordance with lymphocyte proliferative assays. Transplantation 47:542–548.PubMedGoogle Scholar
  119. Smith EF, Kinter LB, Jugus M, Zeid R (1988) Effect of the thrombolytic agent, streptokinase, on the responses to endotoxemia in conscious rats. Circ Shock 25:85–94.PubMedGoogle Scholar
  120. Spero JA, Lewis JH, Hasiba U (1980) Disseminated intra vascular coagulation, findings in 346 patients. Thromb Haemost 43:28–33.PubMedGoogle Scholar
  121. Stadler P, van Amstel SR (1989) Clinico-pathological changes after intravenous administration of endotoxin in the horse. JS Afr Vet Assoc 60:201–205.Google Scholar
  122. Stenbjerg S, Pedersen EB, Laursen H (1983) Coagulation fibrinolytic and antithrombin III profiles monitored in everly infected patients. Thromb Res 31:635–640.Google Scholar
  123. Strieter RM, Remick DG, Ward PA, Spengler RN, Lynch JP, Larrick J, Kunkel SL (1988) Cellular and molecular regulation of tumor necrosis factor alpha production by pentoxifylline. Biochem Biophys Res Commun 155:1230–1236.PubMedGoogle Scholar
  124. Taenaka N, Shimada Y, Hirata T, Nishijima MK, Takezawa J, Yoshiya I, Kambayashi J (1983) Gabexate mesilate (FOY) therapy of disseminated intravascular coagulation due to sepsis. Crit Care Med 11:735–738.PubMedGoogle Scholar
  125. Tanaka H, Kobayashi N, Maekawa T (1985) Effect of thrombin and endotoxin on the in vivo metabolism of antithrombin III in dogs. Thromb Res 40:291–306.PubMedGoogle Scholar
  126. Tanaka H, Kobayashi N, Maekawa T (1986) Studies on production of antithrombin III with special reference to endotoxin-induced DIC in dogs. Thromb Haemost 56:137–143.PubMedGoogle Scholar
  127. Taylor FB, Emerson TE, Jordan R, Chang AK, Blick KE (1988) Antithrombin-III prevents the lethal effects of Escherichia coli infusion in baboons. Circ Shock 26:227–235.PubMedGoogle Scholar
  128. Tracey KJ, Beutler B, Lowry SF, Merryweather J, Wolpe S, Milsark IW, Hariri RJ, Fehey TJ III, Zentella A, Albert JD, Shires GD, Cerami A (1986) Shock and tissue injury induced by recombinant human cachectin. Science 234:470–474.PubMedGoogle Scholar
  129. Triantaphyllopoulos DC (1984) Effects of human anti thrombin III on mortality and blood coagulation induced in rabbits by endotoxin. Thromb Haemost 51:232–235.PubMedGoogle Scholar
  130. Ulevitch RJ, Cochrane CG, Henson PM, Morrison DC, Doe WF (1975) Mediation systems in bacterial lipopolysaccharide-induced hypotension and disseminated intravascular coagulation. I. The role of complement. J Exp Med 142:1570–1590.PubMedGoogle Scholar
  131. Van Deventer SJH, Büller HR, tenCate JW, Aarden LA, Hack CE, Sturk A (1990) Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways. Blood 76:2520–2526.PubMedGoogle Scholar
  132. Vinazzer H (1989) Therapeutic use of antithrombin III in shock and disseminated intravascular coagulation. Semin Thromb Haemost 15:347–352.Google Scholar
  133. Vukajlovich SW, Hoffman J, Morrison DC (1987) Activation of human serum complement by bacterial lipopolysaccharid structural requirements for antibody independent activation of the classical and alternative pathways. Mol Immunol 24:319–331.PubMedGoogle Scholar
  134. Walenga JM, Pifarre R, Hoppensteadt DA, Fareed J (1989) Development of recombinant hirudin as a therapeutic anticoagulant and antithrombotic agent: some objective considerations. Semin Thromb Hemost 15:316–333.PubMedGoogle Scholar
  135. Walsmann P, Markwardt F (1981) Biochemische und pharmakologische Aspekte des Thrombininhibitors Hirudin. Pharmazie 36:653–660.PubMedGoogle Scholar
  136. Ward PA (1967) A plasmin split fragment of C3 as a new chemotactic factor. J Exp Med 126:189–206.PubMedGoogle Scholar
  137. Ward A, Clissold SP (1987) Pentoxifylline: a review of its pharmacodynamic and pharmacokinetic properties and its therapeutic efficacy. Drugs 34:50–97.PubMedGoogle Scholar
  138. Warr TA, Rao LVM, Rapaport SI (1990) Disseminated intravascular coagulation in rabbits induced by administration of endotoxin or tissue factor: Effect of antibodies and measurement of plasma extrinsic pathway inhibitor activity. Blood 75:1481–1489.PubMedGoogle Scholar
  139. Welsh CH, Lien D, Worthen GS, Weil JV (1988) Pentoxifylline decreases endotoxin induced pulmonary neutrophil sequestration and extravascular protein accumulation in the dog. Am Rev Respir Dis 138:1106–1114.PubMedGoogle Scholar
  140. Wilcox JN, Hasko JA, Deisher TA, Bunting S (1989) Identification of cells expressing tissue factor mRNA by in situ hybridization after an in vivo administration of endotoxin to rats. Thromb Haemost 62:1084 a.Google Scholar
  141. Wildgoose P, Berkner KL, Kisiel W (1990) Synthesis, purification, and characterization of an Arg 152-Glu site-directed mutant of recombinant human blood clotting factor VII. Biochemistry 29:3413–3420.PubMedGoogle Scholar
  142. Yoshikawa T, Furukawa Y, Murakami M, Takemura S, Kondo M (1981) Experimental model of disseminated intravascular coagulation induced by sustained infusion of endotoxin. Res Exp Med 179:223–228.Google Scholar
  143. Zabel P, Wolter DT, Schönharting MM, Schade UF (1989) Oxpentifylline in endotoxemia. Lancet II:1474–1477.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • S. Bahrami
    • 1
  • G. Schlag
    • 1
  1. 1.Ludwig Boltzmann Institute for Experimental and Clinical TraumatologyViennaAustria

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