Central Nervous System Response to Trauma

  • E. Kirkman
  • R. A. Little


The aim of the present chapter is to review aspects of the central nervous organisation of the cardio vascular response to peripheral (non-central ner vous) trauma. Two aspects of “trauma” will be con sidered, namely, haemorrhage or loss of circulating fluid, and tissue damage or “injury”. In the context of this chapter, the term “injury” will be used to denote tissue damage and the associated activation of afferent nociceptive fibres, and does not of itself involve loss of circulating fluid. The responses to haemorrhage and “injury” will initially be con sidered separately, before discussing the interaction between the two responses, and the clinical implica tions of this interaction. Finally, ways in which these responses may be modified by three groups of pharmacological agents: general anaesthetic agents, opioid agonists and antagonists, and ethanol, will be described.


Cardiovascular Response Nucleus Tractus Solitarius Ventrolateral Medulla Shock Index Nucleus Ambiguus 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • E. Kirkman
    • 1
  • R. A. Little
    • 1
  1. 1.North Western Injury Research Centre, Stopford BuildingUniversity of ManchesterManchesterGreat Britain

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