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Stellenwert der Schleifendiuretika in der Hypertoniebehandlung

  • Conference paper
Nephrologie

Part of the book series: Innovative Aspekte der klinischen Medizin ((KLIN MED,volume 2))

  • 29 Accesses

Zusammenfassung

Diuretika werden seit ca. 30 Jahren erfolgreich in der Hypertoniebehandlung eingesetzt. Zahlreiche Interventionsstudien zur antihypertensive Therapie, hauptsächlich durchgeführt mit Diuretika und β-Blockern, zeigten eine klare Reduktion des Apoplexrisikos sowie der Herzinsuffizienz, konnten jedoch keine Verbesserung der koronaren Herzkrankheit (KHK) zeigen (McMahon 1990; Collins et al. 1990; Amery et al. 1990). Andererseits fehlen prospektive Studien zu neueren Antihypertonika wie ACE-Hemmer und Kalziumantagonisten in Hinsicht auf Beeinflussung von Herz-Kreislauf-Morbidität bzw. Mortalität von Hypertonikern. Aufgrund ihrer vergleichbaren Wirksamkeit und möglichen metabolischen Vorteile gegenüber Thiaziden und β-Blockern werden sie jedoch schon heute in der ersten Stufe zusammen mit β-Blockern und Diuretika empfohlen. Es gibt allerdings Stimmen, die weiterhin aufgrund fehlender Ergebnisse von Interventionsstudien strikt Diuretika und β-Blocker als First-line-Therapie empfehlen, die anderen Klassen nur bei Kontraindikationen oder Ineffektivität der beiden genannten (Swales 1990).

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Authors
  1. I. Achhammer
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Editor information

Editors and Affiliations

  1. Abteilung Nephrologie Zentrum für Innere Medizin und Dermatologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, W-3000, Hannover, Deutschland

    K. M. Koch

  2. Sektion Pharmakotherapie, Universität Ulm, Steinhövelstraße 9, W-7900, Ulm, Deutschland

    J. Rosenthal

  3. Pathophysiologisches Institut, Universität Bern, Murtenstraße 35, CH-3010, Bern, Switzerland

    H. Fleisch

  4. Forschung Klinik Nephrologie/Onkologie, Boehringer Mannheim GmbH, Sandhofer Straße 116, W-6800, Mannheim 31, Deutschland

    P. Scigalla

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© 1992 Springer-Verlag Berlin Heidelberg

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Achhammer, I. (1992). Stellenwert der Schleifendiuretika in der Hypertoniebehandlung. In: Koch, K.M., Rosenthal, J., Fleisch, H., Scigalla, P. (eds) Nephrologie. Innovative Aspekte der klinischen Medizin, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76708-1_8

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  • DOI: https://doi.org/10.1007/978-3-642-76708-1_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-54173-8

  • Online ISBN: 978-3-642-76708-1

  • eBook Packages: Springer Book Archive

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