Abstract
Until 1910, histological investigation of the skin had revealed a variety of structurally developed end organs in the skin, all of them connected to myelinated afferent nerve fibres. The function of these receptor structures had to remain a matter of speculation until it became possible to record electrophysiologically from identified single nerve fibres. Unitary recording techniques were pioneered by Adrian and Zottermann (1926). Adrian and Umrath (1929) were among the first to combine structure and function in their work on Pacinian corpuscles. Frankenhaeuser’s (1949) Lindblom’s (1965) and Tapper’s (1965) work perfected techniques linking structure and function.
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References
Adrian ED, Umrath K (1929) The impulse discharge from Pacinian corpuscles. J Physiol (Lond) 68:139–154
Adrian ED, Zottermann Y (1926) The impulses produced by sensory endings. Part 2. The response from a single endorgan. J Physiol (Lond) 72:151–171
Akoev GN, Adrianov GN (1989) Synaptic transmission in the mechano- and electroreceptors of the acousticolateral system. In: Autrum H, Ottoson D, Perl ER et al. Progress in Sensory Physiology, vol 9. Springer, Berlin Heidelberg New York, pp 53–95
Anand A, Iggo A, Paintal AS (1979) Lability of granular vesicles in Merkel cells of the type I slowly adapting cutaneous receptors of the cat. J Physiol (Lond) 296:19–20P
Anderson T, Bannister LH, Hamann W (1979) Comparative ultrastructure of touch corpuscles in the rabbit and the cat. J Physiol (Lond) 287:6–7P
Andres KH (1966) Ueber die Feinstruktur der Rezeptoren an Sinushaaren. Z Zellforsch Mikrosk Anat 75:339–365
Baumann KI, Hamann W, Leung (1986a) Mechanical properties of skin and responsiveness of slowly adapting type I mechanoreceptors in rats at different ages. J Physiol (Lond) 371:329–337
Baumann KI, Cheng-Chew SI, Hamann W, Leung MS (1986b) Responsiveness and ultrastructure of slowly adapting type I cutaneous mechanoreceptors in vitamin A deficient rats. J Physiol (Lond) 371:339–349
Baumann KI, Hamann W, Leung MS (1986c) Reduced responsiveness of touch (sa I) receptors in the cat following close arterial infusion of neomycin. Brain Res 377:160–162
Baumann KI, Hamann W, Leung MS (1988) Responsiveness of slowly adapting cutaneous mechanoreceptors after close arterial infusion of neomycin in cats. Prog Brain Res 74:43–49
Baumann KI, Hamann W, Leung MS (1990) Acute effects of neomycin on slowly adapting type I and type II cutaneous mechanoreceptors in the anaesthetized cat and rat. J Physiol (Lond) 425:527–544
Bessou P, Burgess PR, Perl ER, Taylor CB (1971) Dynamic properties of mechanoreceptors with unmyelinated (C) fibres. J Neurophysiol 34:116–131
Brown AG, Iggo A (1963) The structure and function of cutaneous “touch corpuscles” after nerve crush. J Physiol (Lond) 165:28–29P
Brown AG, Iggo A (1967) A quantitative study of cutaneous receptors and afferent fibres in the cat and rabbit. J Physiol (Lond) 193:70–733
Burgess PR, Petit D, Warren R (1968) Receptor types in cat hairy skin supplied by myelinated fibers. J Neurophysiol 31:833–848
Burgess R, Mei J, Nickett RP, Horch KW, Ballinger CM, Poulos DA (1983) The neural signal for skin indentation depth. J Neurosci Res 3:1572–1585
Calof AL, Jones RB, Roberts WJ (1981) Sympathetic modulation of mechanoreceptor sensitivity in frog skin (1981) J Physiol (Lond) 310:481–499
Cash RM, Linden RWA (1982) Effects of sympathetic nerve stimulation on intra-oral mechanoreceptor activity in the cat. J Physiol (Lond) 329:451–463
Cauna N (1962) Functional significance of the submicroscopical, histochemical and microscopical organization of the cutaneous receptor organs. Anat Anz 111 (Suppl 2):181–197
Chambers MR, Andres KH, v. Duering M, Iggo A (1972) The structure and function of the slowly adapting type II mechanoreceptor in hairy skin. Q J Exp Physiol 57:417–445
Chen SY, Gerson S, Meyer J (1973) The fusion of Merkel cell granules with synapse-like structures. J Invest Dermatol 61:290–292
Cooksey EJ, Findlater GS, Iggo A (1984) The response to mechanical stimulation of s.a.I receptors of cats and rats in the presence of calcium antagonists. J Physiol (Lond) 357:30P
Darian-Smith I, Davidson I, Johnson KO (1980) Peripheral neural representation of spatial dimensions of a textured surface moving across the monkey’s finger pad. J Physiol (Lond) 309:135–146
Diamond J, Mills LR, Mearow KM (1988) Evidence that the Merkel cell is not the transducer in the mechanosensory Merkel-cell-neurite complex. Prog Brain Res 74:51–56
Douglas WW, Ritchie JM (1957) On excitation of non-medullated afferent fibres in the saphenous nerve, which signal touch. J Physiol (Lond) 139:385–399
Ferrington DG, Rowe MJ (1980) Functional capacities of tactile afferent fibres in neonatal kittens. J Physiol (Lond) 307:335–353
Fiekers JF (1983) Effects of aminoglycoside antibiotics, streptomycin and neomycin on neuromuscular transmission. 1. Presynaptic considerations. J Pharmacol Exp Ther 225:487–502
Fjaellbrandt N, Iggo A (1961) The effect of histamine, 5-hydroxytryptamine and acetylcholine on cutaneous afferent fibres. J Physiol (Lond) 156:570–590
Frankenhaeuser B (1949) Impulses from a cutaneous receptor with slow adaptation and low mechanical threshold. Acta Physiol Scand 18:67–74
Gardner EP, Palmer CI (1989) Simulation of motion on the skin. I. Receptive fields and temporal frequency coding by cutaneous mechanoreceptors of OPTACON pulses delivered to the hand. J Neurophysiol 62:1410–1436
Gardner EP, Palmer CI (1990) Simulation of motion on the skin. II. Mechanisms used by rapidly adapting cutaneous mechanoreceptors in the primate hand for spatiotemporal resolution and two-point discrimination. J Neurophysiol 63:841–859
Gentle MJ (1989) Cutaneous sensory afferents recorded from the nervous intermandibularis of Gallus gallus var. domesticus. J Comp Physiol A 164:763–774
Gottschaldt KM (1974) The physiological basis of tactile sensibility in the beak of geese. J Comp Physiol 95:29–47
Gottschaldt KM, Lausmann S (1974) The peripheral morphological basis of tactile sensibility in the beak of geese. Cell Tissue Res 153:477–496
Gottschaldt KM, Vahle-Hinz C (1981) Merkel cell receptors: structure and transducer function. Science 214:183–186
Gottschaldt KM, Vahle-Hinz C (1982) Evidence against transmitter function of met-enkephalin and chemosynaptic impulse generation in “Merkel cell” mechanoreceptors. Exp Brain Res 45:459–463
Gottschaldt KM, Iggo A, Young DW (1973) Functional characteristics of mechanoreceptors in sinus hair follicles of the cat. J Physiol (Lond) 235:287–315
Gottschaldt KM, Fruhstorfer H, Schmidt W, Kraft I (1982) Thermosensitivity and its possible fine-structural basis in mechanoreceptors in the beak skin of geese. J Comp Neurol 205:219–245
Gregory JE (1973) An electrophysiological investigation of the receptor apparatus of the duck’s bill. J Physiol (Lond) 229:151–164
Hartschuh W, Weihe E (1988) Multiple messenger candidates and marker substances in the mammalian Merkel cell-axon complex: a light and electron microscopic immunohistochemical study. Prog Brain Res 74:181–187
Hartschuh W, Weihe E, Buechler M, Helmstaedter GE, Feuerle GE, Forssmann WG (1979) Met-enkephalin-like immunoreactivity in Merkel cells. Cell Tissue Res 201:342–348
Heinbecker P, O’Leary JL, Bishop GH (1933) Nature and source of fibres contributing to the saphenous nerve in the cat. Am J Physiol 104:23–35
Horch KW, Whitehorn D, Burgess PR (1974) Impulse generation in type I cutaneous mechanoreceptors. J Neurophysiol 37:267–281
Hudspeth AJ, Kroese ABA (1983) Voltage-dependent interaction of dihydrostreptomycin with the transduction channels in bullfrog sensory hair cells. J Physiol (Lond) 345:66P
Iggo A (1959) Cutaneous heat and cold receptors with slowly conducting C-afferent fibres. Q J Exp Physiol 44:362–370
Iggo A (1960) Cutaneous mechanoreceptors with afferent C-fibres. J Physiol (Lond) 152:337–353
Iggo A (1964) Temperature discrimination in the skin. Nature 204:481–483
Iggo A (1982) Cutaneous sensory mechanisms. In: Barlow H, Molke D (eds) The senses text in the physiological sciences. Cambridge Univ Press, Cambridge, pp 369–408
Iggo A, Findlater GS (1984) A review of Merkel cell mechanisms. In: Hamann W, Iggo A (eds) Sensory receptor mechanisms. World Scientific, Singapore, pp 117–132
Iggo A, Muir AR (1969) The structure and function of a slowly adapting touch corpuscles in hairy skin. J Physiol (Lond) 200:763–796
Johansson RS, Vallbo AB (1979) Tactile sensibility in the human hand: relative and absolute densities of four types of mechanoreceptive units in glabrous skin. J Physiol (Lond) 286:293–300
Johansson RS, Vallbo AB (1983) Tactile sensory coding in the glabrous skin of the human hand. TINS 6:27–32
Johansson RS, Vallbo AB, Westling (1980) Thresholds of mechanosensitive afferents in the human hand as measured with v. Frey hairs. Brain Res 184:343–351
Kenton B, Kruger L, Woo M (1971) Two classes of slowly adapting mechanoreceptor fibres in reptile cutaneous nerve. J Physiol (Lond) 212:21–44
LaMotte RH, Whitehouse J (1986) Tactile detection of a dot on a smooth surface: peripheral neural events. J Neurophysiol 56:1109–1128
Leung MS (1986) Responsiveness of s.a.I cutaneous mechanoreceptors during aging and in degenerative skin conditions. PhD Thesis, Chinese University of Hong Kong, Hong Kong
Lindblom U (1965) Properties of touch receptors in distal glabrous skin of the monkey. J Neurophysiol 28:966–985
Llinas RR (1977) Calcium release and transmitter release in squid synapse. In: Cowan WM, Forendelli JA (eds) Society for neuroscience symposia vol II. Society for Neurosciences, Bethesda, pp 139–160
Loewenstein R (1956) Modulation of cutaneous mechanoreceptors by sympathetic stimulation. J Physiol (Lond) 132:40–60
Loewenstein WR, Altamirano-Orrego R (1956) Enhancement of activity in a Pacinian corpuscle by sympathomimetic agents. Nature 4545:1292–1293
Lynn B, Carpenter SE (1982) Primary afferent units from the hairy skin of the rat hind limb. Brain Res 218:29–43
Mearow KM, Diamond J (1988) Merkel cells and the mechanosensitivity of normal and regenerating nerves in Xenopus skin. Neuroscience 26:695–708
Millard CL, Woolf CJ (1988) Sensory innervation of the hairs of the rat hindlimb: a light microscopic analysis. J Comp Neurol 277:183–194
Munger BL, Ide C (1988) The structure and function of cutaneous sensory receptors. Arch Histol Cytol 51:1–34
Necker R (1974) In: Proc Rheinisch-westphaelische Akademie der Wissenschaften, vol 53. Westdeutichev Verlag, p 134
Nordin M (1990) Low threshold mechanosensitive and nociceptive units with unmyelinated (C) fibres in the human supraorbital nerve. J Physiol (Lond) 426:229–240
Ogawa H, Iggo A (1977) Dependence of the response characteristics of glabrous rapidly adapting units in the cat on the stratum corneum. Brain Res 126:167–171
Ogawa H, Katsushi M, Yamashita Y (1981a) Physiological characteristics of low threshold mechanoreceptor afferent units innervating frog skin. Q J Exp Physiol 66:105–116
Ogawa H, Morimoto K, Yamashita Y (1981b) Physiological characteristics of low threshold mechanoreceptor afferent units innervating frog skin. J Q Exp Physiol 66:105–116
Pacitti EG (1988) Neuropharmacology of the s.a.I sensory receptor. PhD Thesis, Edinburgh University
Pacitti EG, Findlater GS (1988) Calcium channel blockers and Merkel cells. Prog Brain Res 74:37–42
Pierce JP, Roberts WJ (1981) Sympathetically induced changes in the response of guard hair and type II receptors in the cat. J Physiol (Lond) 314:411–428
Pinkus F (1905) Ueber Hautsinnesorgane neben dem menschlichen Haar (Haarscheiben) und ihre vergleichend-anatomische Bedeutung. Arch Mikrosk Anat 65:121–179
Proske U (1969) Vibration sensitive mechanoreceptors in snake skin. Exp Neurol 23:187–194
Pubols BH (1982a) Factors affecting cutaneous mechanoreceptor response. I. Constant-force versus constant displacement stimulation. J Neurophysiol 47:515–529
Pubols BH (1982b) Factors affecting cutaneous mechanoreceptor response. II. Changes in mechanical properties of skin with repeated stimulation. J Neurophysiol 47:530–542
Pubols BH, Pubols LM (1983) Tactile receptor discharge and mechanical properties of glabrous skin. Fed Proc 42:2528–2535
Roberts WJ, Elardo SM, King KA (1985) Sympathetically induced changes in the responses on slowly adapting type I receptors in cat skin. Somatosens Res 3:223–236
Schiff JD (1974) Role of sympathetic innervation of the Pacinian corpuscle. J Gen Physiol 63:601–608
Sinclair D (1981) Cutaneous sensation 1980. Anaesthesiol Intensive Care Med 9:163–173
Smith KR Jr, Creech BJ (1967) Effects of pharmacological on the physiological response of hair discs. Exp Neurol 19:477–482
Straile WE (I960) Sensory hair follicles in mammalian skin. Am J Anat 106:133–147
Tapper DN (1965) Stimulus-response relationships in the cutaneous slowly-adapting mechanoreceptor in hairy skin of the cat. Exp Neurol 13:364–385
Tuckett RP, Horch KW, Burgess PR (1978) Response of cutaneous hair and field mechanoreceptors in cat to threshold stimuli. J Neurophysiol 41:138–149
Werner G, Mountcastle VB (1965) Neural activity in mechanoreceptive cutaneous afferents: stimulus response relations, Weber function and information transmission. J Neurophysiol 28:359–397
Yamashita Y, Ogawa H, Taniguchi K (1986) Differential effects of manganese and magnesium on two types of slowly adapting cutaneous mechanoreceptor afferent units in frogs. Pfluegers Arch Eur J Physiol 406:218–224
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Hamann, W. (1992). Comparative Physiology of Cutaneous Mechanoreceptors. In: Ito, F. (eds) Comparative Aspects of Mechanoreceptor Systems. Advances in Comparative and Environmental Physiology, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76690-9_8
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DOI: https://doi.org/10.1007/978-3-642-76690-9_8
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