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Comparative Anatomy of Mammalian Harderian Glands

  • Tatsuo Sakai

Abstract

The mammalian eye possesses two sets of major exocrine glands: one in the inner canthus and the other in the outer canthus. The former, which may be named the medial ocular glands, includes the Harderian gland and the nictitans gland. These two glands are distinguished on the basis of the nature of their secretions. The Harderian gland secretes lipids by a merocrine mechanism whereas the nictitans gland secretes glycoproteins (Sakai 1981). The latter set, which may be called the lateral ocular glands, is regarded generally as the lacrimal gland, and is divided into two groups on the basis of their gross anatomy (Sakai 1989).

Keywords

Lacrimal Gland Mongolian Gerbil Comparative Anatomy Harderian Gland Meriones Unguiculatus 
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References

  1. Abe J, Sugita A, Katsume Y, Yoshizuka M, Tamura N, Iwanaga S, Nishida T (1980) Scanning electron microscopic observations of the Harderian gland in rat. Kurume Med J 27:239–246PubMedCrossRefGoogle Scholar
  2. Abe J, Sugita A, Hamasaki M, Nakamura K, Iwanaga S, Nagae K, Atsuji K, Tsunawaki A, Abe T, Matsumoto T, Yo S, Murakami M (1981) Scanning electron microscopic observations of the myoepithelial cells of normal and contracting status in the rat Harderian gland. Kurume Med J 28:103–112PubMedCrossRefGoogle Scholar
  3. Akagi N, Morimoto T, Watanabe M (1987) The Harderian gland and the porphyrins. Bull Osaka Med Sch 33:97–115PubMedGoogle Scholar
  4. Akiyama K (1961) Anatomical study of the orbit and its contents in albino rat (in Japanese). Acta Soc Ophthalmol Jpn 65:1718–1735Google Scholar
  5. Baccari G, Minucci S, Di Matteo L, Chieffi G (1990) Harderian gland and the lacrimal gland of the lizard Podarcis s. sicula: histology, histochemistry, and ultrastructure. Anat Rec 226:269–278PubMedCrossRefGoogle Scholar
  6. Björkman B, Nicander L, Schantz B (1960) On the histology and ultrastructure of the Harderian gland in rabbits. Z Zellforsch Mikrosk Anat 52:93–104CrossRefGoogle Scholar
  7. Brownscheidle CM, Niewenhuis RJ (1978) Ultrastructure of the Harderian gland in male albino rats. Anat Rec 190:735–753PubMedCrossRefGoogle Scholar
  8. Bucana CD, Nadakavukaren MJ (1972a) Innervation of the hamster Harderian gland. Science 175:205–206PubMedCrossRefGoogle Scholar
  9. Bucana CD, Nadakavukaren MJ (1972b) Fine structure of the hamster Harderian gland. Z Zellforsch Mikrosk Anat 129:178–187PubMedCrossRefGoogle Scholar
  10. Bucana CD, Nadakavukaren MJ (1972c) Ultrastructural investigation of the postnatal development of the hamster Harderian gland. I. Cell division. Z Zellforsch Mikrosk Anat 135:149–153PubMedCrossRefGoogle Scholar
  11. Bucana CD, Nadakavukaren MJ (1973) Ultrastructural investigation of the postnatal development of the hamster Harderian gland. II. Male and female. Z Zellforsch Mikrosk Anat 142:1–12PubMedCrossRefGoogle Scholar
  12. Buschke W (1933) Die Hautdrüsenorgane (Hardersche Drüsen, Inguinaldrüsen, Präputialdrüsen, Analdrüsen, Kaudaldrüsen, Kieferdrüsen) der Laboratoriumsnagetiere und die Frage ihrer Abhängigkeit von den Geschlechtsdrüsen. Z Zellforsch Mikrosk Anat 18:217–243CrossRefGoogle Scholar
  13. Butler JM, Ruskell GL, Cole DF, Unger WG, Zhang SQ, Blank MA, McGregor GP, Bloom SR (1984) Effects of VIIth (facial) nerve degeneration on vasoactive intestinal polypeptide and substance P levels in ocular and orbital tissues of the rabbit. Exp Eye Res 39:523–532PubMedCrossRefGoogle Scholar
  14. Coujard M (1974) La <Hardérisation> de la glande de Loewenthal chez le Rat blanc. C R Seances Soc Biol 168:231–233Google Scholar
  15. Davis FA (1929) The anatomy and histology of the eye and orbit of the rabbit. Trans Am Ophthalmol Soc 27:401–441Google Scholar
  16. Fahrenholz C (1937) Drüsen der Mundhöhle. In: Bolk L, Göppert E, Kallius E, Lubosch W (eds) Handbuch der vergleichenden Anatomie der Wirbeltiere vol 3. Urban & Schwarzenberg, Berlin, pp 115–210Google Scholar
  17. Griffiths M (1978) The biology of the monotremes. Academic Press, New YorkGoogle Scholar
  18. Harder JJ (1694) Glandula nova lachrymalis una cum ductu excretorio in cervis et damis. Acta-Eruditorium-Lipsiae 1694:49–52Google Scholar
  19. Harriman AE, Thiessen DD (1985) Harderian letdown in male Mongolian gerbils (Meriones unguiculatus) contributes to proceptive behavior. Horm Behav 19:213–219PubMedCrossRefGoogle Scholar
  20. Hugo J, Vokuraka M, Sanitrâk J, Melkovâ Z, Janousek V (1989) First demonstration of porphyrins in the lacrimal glands: similarity to the Harderian gland. Biomed Biochim Acta 48:K1–K4PubMedGoogle Scholar
  21. Huhtala A, Huikuri KT, Palkama A, Tervo T (1977) Innervation of the rat Harderian gland by adrenergic and cholinergic nerve fibres. Anat Rec 188:263–271PubMedCrossRefGoogle Scholar
  22. Jackson AHD, Kenner GW, Smith KM, Suckling CJ (1976) Pyrroles and related compounds — XXXVII Harderoporphyrin. Tetrahedron 32:2757–2762CrossRefGoogle Scholar
  23. Johnston HS, McGadey J, Thompson GG, Moore MR, Payne AP (1983) The Harderian gland, its secretory duct and porphyrin content in the Mongolian gerbil (Meriones unguiculatus). J Anat 137:615–630PubMedGoogle Scholar
  24. Johnston HS, McGadey J, Thompson GG, Moore MR, Breed WG, Payne AP (1985) The Harderian gland, its secretory duct and porphyrin content in the Plains mouse (Pseudomys australis). J Anat 140:337–350PubMedGoogle Scholar
  25. Johnston HS, McGadey J, Payne AP, Thompson GG, Moore MR (1987) The Harderian gland, its secretory duct and porphyrin content in the woodmouse (Apodemus sylvaticus). J. Anat 153:17–30PubMedGoogle Scholar
  26. Johnston RE (1986) Effects of female odors on the sexual behavior of male hamsters. Behav Neural Biol 46:168–188PubMedCrossRefGoogle Scholar
  27. Jost UL, Kühnel W, Schimassek H (1974) A morphological and histochemical analysis of the Harderian gland in the rabbit. Cytobiologie 8:440–456Google Scholar
  28. Kaiho M, Ichikawa A (1982) An application of the ferrocyanide-reduced osmium tetroxide for the ultrastructural analysis of gerbil, Meriones unguiculatus Harderian gland. J Electron Microsc 31:410–414Google Scholar
  29. Kanwar KC (1960) Morphological and cytochemical studies on the Harderian glands of rats. Cellule 61:129–143Google Scholar
  30. Kelényi G, Orbán S (1964) Electron microscopy of the Harderian gland of the rat: maturation of the acinar cells and genesis of the secretory droplets. Acta Morphol Acad Sci Hung 13:155–166Google Scholar
  31. Kühnel W (1971) Struktur und Cytochemie der Harderschen Drüse von Kaninchen. Z Zellforsch Mikrosk Anat 119:384–404PubMedCrossRefGoogle Scholar
  32. Kühnel W (1974) Zur funktionellen Morphologie der Harderschen Drüse des Schweins (Sus scropha L.). Mit Bemerkungen zur Frage ihrer Innervation. Berl Münch Tieraurztl Wochenschr 87:9–15, 21–25Google Scholar
  33. Kühnel W, Wrobel KH (1968) Histochemische Studien an der Harderschen Drüse des Kaninchens. Morphol Jahrb 111:493–500Google Scholar
  34. Loewenthal N (1892a) Notiz über die Harder’schen Drüse des Igels. Anat Anz 7:48–54Google Scholar
  35. Loewenthal N (1892b) Beitrag zur Kenntnis der Harder’schen Drüse bei den Säugetieren. Anat Anz 7:546–556Google Scholar
  36. Loewenthal N (1896) Drüsenstudien. I. Die Harder’schen Drüse. Int Mschr Anat Physiol 13:27–65Google Scholar
  37. Michael MI, Khalil SH, Matta CA, Rizk TA (1988) Normal development of the ocular glands of the mouse. Folia Morphol (Prague) 36:47–52Google Scholar
  38. Miessner H (1900) Die Drüsen des dritten Augenlides einiger Säugetiere. Arch Wiss Prakt Tierheilkd 26:122–154Google Scholar
  39. Müller HB (1969a) Die postnatale Entwicklung der Harderschen Drüse der weissen Ratte. I. Lichtmikroskopische Befunde. Z Zellforsch Mikrosk Anat 100:421–438PubMedCrossRefGoogle Scholar
  40. Müller HB (1969b) Die postnatale Entwicklung der Harderschen Drüse der weissen Ratte. II. Fermenthistochemische Befunde. Histochemie 20:181–196PubMedCrossRefGoogle Scholar
  41. Müller HB (1970) Untersuchungen zur postnatalen Entwicklung der Harderschen Drüse der Ratte. Verh Anat Ges 64:503–509PubMedGoogle Scholar
  42. Nadakavukaren MJ, Lin WL (1983) Influence of short photoperiods on the ultrastructure of hamster Harderian glands. Cell Tissue Res 233:209–213PubMedCrossRefGoogle Scholar
  43. Norvell JE, Clabough JW (1972) Adrenergic and cholinergic innervation of the hamster Harderian gland. Science 178:1102–1103PubMedCrossRefGoogle Scholar
  44. Otsuru O, Otsuka H, Kasama T, Seyama Y, Sakai T, Yohro T (1983) The characterization of 2,3-alkanediol diacyl esters obtained from the Harderian glands of Mongolian gerbil (Meriones unguiculatus). J Biochem 94:2049–2054PubMedGoogle Scholar
  45. Pangerl A, Pangerl B, Buzzell GR, Jones DJ, Reiter RJ (1989) Characterization of beta-adrenoceptors in the Syrian hamster Harderian gland: sexual differences and effects of either castration or superior cervical ganglionectomy. J Neurosci Res 22:456–460PubMedCrossRefGoogle Scholar
  46. Paule WJ (1957) The comparative histochemistry of the Harderian gland. Dissertation, Ohio State University, Columbus, OHGoogle Scholar
  47. Payne AP (1977) Pheromonal effects of Harderian gland homogenates on aggressive behaviour in the hamster. J Endocrinol 73:191–192PubMedCrossRefGoogle Scholar
  48. Payne AP (1979) The attractiveness of Harderian gland smears to sexually naive and experienced male golden hamsters. Anim Behav 27:897–904PubMedCrossRefGoogle Scholar
  49. Payne AP, McGadey J, Johnston HS, Moore MR, Thompson GG (1982) Mast cells in the hamster Harderian gland: sex differences, hormonal control and relationship to porphyrin. J Anat 135:451–461PubMedGoogle Scholar
  50. Payne AP, McGadey J, Johnston HS (1985) Interstitial porphyrins and tubule degeneration in the hamster Harderian gland. J Anat 140:25–36PubMedGoogle Scholar
  51. Pévet P, Heth G, Hiam A, Nevo E (1984) Photoperiod perception in the blind mole rat (Spalax ehrenbergi, Nehring): involvement of the Harderian gland, atrophied eyes, and melatonin. J Exp Zool 232:41–50PubMedCrossRefGoogle Scholar
  52. Prince JH (1956) Comparative anatomy of the eye. Charles C Thomas, Springfield, pp 298–305Google Scholar
  53. Pütter A (1903) Die Augen der Wassersäugethiere. Zool Jahrb Abt Anat Ontogen 17:99–402Google Scholar
  54. Sakai T (1981) The mammalian Harderian gland: morphology, biochemistry, function and phylogeny. Arch Histol Jpn 44:299–333PubMedCrossRefGoogle Scholar
  55. Sakai T (1989) Major ocular glands (Harderian gland and lacrimal gland) of the musk shrew (Suncus murinus) with a review on the comparative anatomy and histology of the mammalian lacrimal glands. J Morphol 201:39–57PubMedCrossRefGoogle Scholar
  56. Sakai T, van Lennep EW (1984) The Harderian gland in Australian marsupials. J Mammal 65:159–162CrossRefGoogle Scholar
  57. Sakai T, Yohro T (1981) A histological study of the Harderian gland of Mongolian gerbils, Meriones meridianus. Anat Rec 200:259–270PubMedCrossRefGoogle Scholar
  58. Sashima M, Hatakeyama S, Satoh M, Suzuki A (1989) Harderianization is another sexual dimorphism of rat exorbital lacrimal gland. Acta Anat 135:303–306PubMedCrossRefGoogle Scholar
  59. Schwarz-Karsten H (1937) Über die Orbitaldrüsen von Lacerta agilis, Lacerta muralis, Ophisops elegans, Tarentola mauretanica und Tropidonotus natrix. Morphol Jahrb 80:248–279Google Scholar
  60. Shinoda S (1958) Harder’s gland in some mammals. Igaku Kenkyu (Acta Medica) 28:4623–4635 (in Japanese)Google Scholar
  61. Shirama K, Furuya T, Takeo Y, Shimizu K, Maekawa K (1979) Neural control of the Harderian gland in the rat. Zool Mag 88:149–154 (in Japanese)Google Scholar
  62. Shirama K, Harada T, Kohda M, Hokano M (1988) Fine structure of melanocytes and macrophages in the Harderian gland of the mouse. Acta Anat 131:192–199PubMedCrossRefGoogle Scholar
  63. Sun CY, Nadakavukaren MJ (1980) Effect of testosterone on the female hamster Harderian gland pigmentation and ultrastructure. Cell Tissue Res 207:511–517PubMedCrossRefGoogle Scholar
  64. Tashiro S, Smith CC, Badgen E, Kazur E (1940) Chromodacryorrhea, a new criterion for biological assay of acetylcholine. Proc Sci Exp Biol Med 44:658–661Google Scholar
  65. Thiessen DD (1988) Body temperature and grooming in the Mongolian gerbil. Ann NY Acad Sci 525:27–39PubMedCrossRefGoogle Scholar
  66. Thiessen DD, Kittereil EMW (1980) The Harderian gland and thermoregulation in the gerbil (Meriones unguiculatus). Physiol Behav 24:417–424PubMedCrossRefGoogle Scholar
  67. Thiessen DD, Graham M, Perkins J, Marcks S (1977) Temperature regulation and social grooming in the Mongolian gerbil (Meriones unguiculatus). Behav Biol 19:279–288PubMedCrossRefGoogle Scholar
  68. Tsukahara S, Jacobowitz DM (1987) Peptidergic innervation of the rat Harderian gland. Histochemistry 87:233–236PubMedCrossRefGoogle Scholar
  69. Tsutsumi A, Iwata K, Ogawa K, Matsuura K (1966) Histochemical and electron microscopic observations on the Harderian gland of the albino rat. Arch Histol Jpn 27:553–567 (in Japanese)PubMedCrossRefGoogle Scholar
  70. Vega-Alvarez JA, Menendez-Pelaez A, Coalla-Perez C, Martinez-Telleria A (1989) Sexual dimorphism in the cholinergic innervation of the hamster (Mesocricetus auratus) Harderian glands. Z Mikrosk Anat Forsch 103:166–172PubMedGoogle Scholar
  71. Vianna GF, Cruz AR, Azoubel R (1975a) Mitotic activity and nuclear/cytoplasmatic ratio of the lachrymal and Harderian glands of the rat during postnatal life. Acta Anat 92:1–7PubMedCrossRefGoogle Scholar
  72. Vianna GF, Cruz AR, Azoubel R (1975b) Allometric study of the lachrymal and Harderian glands of the rat during postnatal life. Acta Anat 92:161–170PubMedCrossRefGoogle Scholar
  73. Waller GH, Harrison RJ (1978) The significance of eyelid glands in delphinids. Aquat Mam 6:1–9Google Scholar
  74. Walter A (1925) Über die Hautdrüsen mit Lipoidsekretion bei Nagern. Beitr Pathol Anat 73:142–167Google Scholar
  75. Weaker FJ (1981) Light microscopic and ultrastructural features of the Harderian gland of the nine-banded armadillo. J Anat 133:49–65PubMedGoogle Scholar
  76. Wetterberg L, Geller E, Yuwiler A (1970) Harderian gland: an extraretinal photoreceptor influencing the pineal gland in neonatal rats? Science 167:884–885PubMedCrossRefGoogle Scholar
  77. Wiedersheim R (1909) Vergleichende Anatomie der Wirbeltiere. Gustav Fischer, JenaGoogle Scholar
  78. Winterhager E, Kühnel W (1983) Membrane specializations of the cells of the Harderian gland of the rabbit with particular reference to the mechanism of exocytosis. Cell Tissue Res 231:623–636PubMedCrossRefGoogle Scholar
  79. Woodhouse MA, Rhodin JAG (1963) The ultrastructure of the Harderian gland of the mouse with particular reference to the formation of its secretory product. J Ultrastruct Res 9:76–98CrossRefGoogle Scholar
  80. Wooding FBP (1980) Lipid droplet secretion by the rabbit Harderian gland. J Ultrastruct Res 71:68–78PubMedCrossRefGoogle Scholar
  81. Yamashita T, Takahashi A, Honjin R (1980) The spatial aspect of the mouse orbital venous sinus. Okajimas Folia Anat Jpn 56:329–336PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Tatsuo Sakai
    • 1
  1. 1.Department of Anatomy, School of MedicineJuntendo UniversityBunkyo-ku, Tokyo 113Japan

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