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Heat Shock pp 235–245Cite as

Expression of Stress Proteins on the Surface of Cells of the Immune System

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Abstract

Localization of stress proteins on plasma membranes is of fundamental biologic and immunologic interest (reviewed in Winfield and Jarjour, 1990). For example, the detection of HSP70 as a peptide-binding protein on the surface of antigen-presenting cells implies a role for at least some members of this family of stress proteins in the recognition of MHC class II/antigen peptide complexes by T cell receptors (TCRs) (Lakey etal., 1987; Vanbuskirk etal., 1989). Furthermore, surface expression of autologous stress proteins, or stress protein epitopes, can render cells susceptible to specific immunological attack (Koga etal., 1989; Ottenhof etal., 1988). Relatively little information is available concerning which stress proteins are expressed on lymphoid cells and under what circumstances, however. In this review, recent immunologic and biochemical data from our laboratories that bear on these issues are summarized briefly.

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Author information

Authors and Affiliations

  1. Division of Rheumatology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27514, USA

    W. N. Jarjour & J. B. Winfield

  2. The Lung Biology Research Center, University of California, San Francisco, California, 94143, USA

    W. J. Welch

Authors
  1. W. N. Jarjour
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  2. W. J. Welch
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  3. J. B. Winfield
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Editor information

Editors and Affiliations

  1. International Institute of Genetics and Biophysics, Via Marconi 12, 80125, Naples, Italy

    Bruno Maresca

  2. Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, 1103 E 57th Street, 60637, Chicago, IL, USA

    Susan Lindquist

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© 1991 Springer-Verlag Berlin Heidelberg

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Jarjour, W.N., Welch, W.J., Winfield, J.B. (1991). Expression of Stress Proteins on the Surface of Cells of the Immune System. In: Maresca, B., Lindquist, S. (eds) Heat Shock. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76679-4_26

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  • DOI: https://doi.org/10.1007/978-3-642-76679-4_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76681-7

  • Online ISBN: 978-3-642-76679-4

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