The C57BL/KaLwRij Mouse Model of B-Cell Proliferative Disorders. Is there a Relationship Between Benign Monoclonal Gammopathy and Multiple Myeloma ?

Conference paper


The C57BL/KaLwRij mice have been shown to spontaneously develop a variety of B-cell proliferative disorders with aging. Over 80% of mice of this strain develop benign monoclonal gammopathy (BMG) which in most aspects is indistinguishable from that described in humans (for reviews see Radl,1981, 1986, 1989). About one third of old mice at necropsy and histopathology examination were shown to suffer from lymphoma, mainly of the follicle center cell type, the majority of which is most likely of the B cell origin (unpublished results). Nearly 1% of mice older than two years develop Waldenstrom’s macroglobulinaemia-like lymophoma (WM) (Radl et al. 1989) or multiple myeloma (MM) (Radl et al. 1988).


Multiple Myeloma C57BL Mouse Marrow Bone Lesion Proliferative Disorder Spontaneous Origin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Abbas AK, Moser C (1984) Idiotypic suppression of B-cell-derived tomors. Models for lymhocyte regulation. In: Greene MI, Nisonoff A, (eds) The biology of idiotypes, Plenum Press, New York, London, p 315–325Google Scholar
  2. Croese JW, Vas Nunes CM, Radl J, van den Enden-Vieveen MHM, Brondijk RJ and Boersma WJA (1987) The 5T2 mouse multiple myeloma model: Characterization of 5T2 cells within the bone marrow. Br J Cancer 56: 555–560PubMedCrossRefGoogle Scholar
  3. Kyle RA, Greipp PR (1980) Smoldering multiple myeloma. New Engl J Med 302: 1347–1349PubMedCrossRefGoogle Scholar
  4. Lynch RG, Rohrer JW, Odermatt B, Gebel HD, Autry JR and Hoover RG (1979) Immunoregulation of murine myeloma cell growth and differentiation: a monoclonal model of B cell differentiation. Immunol Rev 48: 45–80PubMedCrossRefGoogle Scholar
  5. Radl J (1981) Benign monoclonal gammopathy (Idiopathic paraproteinemia) . Amer J Pathol 105: 91–93Google Scholar
  6. Radl J (1986) Benign Monoclonal Gammapathy (BMG). Current Topics Microbiol Immunol 132: 221–224CrossRefGoogle Scholar
  7. Radl J (1989) Benign Monoclonal Gammopathy. Model No 234, Supplemental Update, In: Capen CC, Jones TC and Migaki G (eds) Handbook: Animal Models of Human Disease, Fasc.17, Registry of Comparative Pathology, Washington,DCGoogle Scholar
  8. Radl J, Hollander CF, van den Berg P, and de Glopper E (1978) Idiopathic paraproteinaemia I. Studies in an animal model - the ageing C57BL/KaLwRij mouse. Clin exp Immunol 33: 35–402Google Scholar
  9. Radl J, de Glopper E, Schuit HRE and Zurcher C (1979) Idiopathic paraproteinemia II. Transplantation of the paraprotein producing clone from old to young C57BL/KaLwRij mice. J Immunol 122: 609–613PubMedGoogle Scholar
  10. Radl J, Heidt PJ, Knaan-Shanzer S and van Zwieten MJ (1984) Idiopathic paraproteinaemia IV. The role of genetic factors in the development of monoclonal B cell proliferative disorders - a study in the ageing C57BL/KaLwRij and CBA/BrARij mouse radiation chimeras. Clin exp Immunol 57: 213–216Google Scholar
  11. Radl J, van den Enden-Vieveen MHM, van den Akker ThW, Benner R, Haaijman JJ and Zurcher C (1985) Idiopathic paraproteinaemia V. Expression of Ighl and Igh5 allotypes within the homogeneous immunoglobulins of ageing (C57BL/LiARij x CBA/BrARij)Fl mouse. Clin exp Immunol 62: 405–411PubMedGoogle Scholar
  12. Radl J, Croese JW, Zurcher C, van den Enden-Vieveen MHM and de Leeuw AM (1988) Animal Model of Human Disease: Multiple Myeloma. Amer J Pathol 132: 593–597Google Scholar
  13. Radl J, van den Enden-Vieveen MHM, Zurcher C, Roholl PJM and Blauw E. (1989) Morbus Waldenstrom-like lymphoma in the aging C57BL/KaLwRij mouse. In: Radl J and van Camp B (eds) Monoclonal Gammapathies - Clinical significance and basic mechanisms. Vol.12, Topics in Aging Research in Europe, Eurage, Rijswijk, p 233–238Google Scholar
  14. Radl J, Punt YA, van den Enden-Vieveen MHM, Bentvelzen PAJ Bakkus MHC, van den Akker TW and Benner R (1990) The 5T mouse multiple myeloma model: absence of c-myc oncogene rearrangement in early transplant generations. Br J Cancer 61: 276–278PubMedCrossRefGoogle Scholar
  15. Van den Akker ThW, Tio-Gillen AP, Benner R, Zurcher C and Radl J (1987) The influence of H-2 genetic factors on the development of benign monoclonal gammopathy in ageing H-2 congenic C57BL and BALB mice. Immunology, 61: 403–408PubMedGoogle Scholar
  16. Van den Akker ThW, de Glopper,van den Veer E, Radl J and Benner R. (1988) The influence of genetic factors associated with the immunoglobulin heavy chain locus on the development of benign monoclonal gammapathy in aging Igh congenic mice. Immunology 65: 31–35PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • J. Radl
    • 1
  1. 1.TNO Institute for Experimental GerontologyRijswijkThe Netherlands

Personalised recommendations