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The C57BL/KaLwRij Mouse Model of B-Cell Proliferative Disorders. Is there a Relationship Between Benign Monoclonal Gammopathy and Multiple Myeloma ?

Conference paper

Abstract

The C57BL/KaLwRij mice have been shown to spontaneously develop a variety of B-cell proliferative disorders with aging. Over 80% of mice of this strain develop benign monoclonal gammopathy (BMG) which in most aspects is indistinguishable from that described in humans (for reviews see Radl,1981, 1986, 1989). About one third of old mice at necropsy and histopathology examination were shown to suffer from lymphoma, mainly of the follicle center cell type, the majority of which is most likely of the B cell origin (unpublished results). Nearly 1% of mice older than two years develop Waldenstrom’s macroglobulinaemia-like lymophoma (WM) (Radl et al. 1989) or multiple myeloma (MM) (Radl et al. 1988).

Keywords

Multiple Myeloma C57BL Mouse Marrow Bone Lesion Proliferative Disorder Spontaneous Origin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • J. Radl
    • 1
  1. 1.TNO Institute for Experimental GerontologyRijswijkThe Netherlands

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