Cytogenetic Abnormalities in Multiple Myeloma

  • Brian G. M. Durie
  • Elizabeth E. Vela
  • Valerie Baum
Conference paper

Abstract

Cytogenic studies in multiple myeloma have been very difficult because of the predominantly low proliferative activity in this disease (1-7). In the series reported to date the most commonly affected chromosomes have been chromosomes 1 and 14: a variety of translocations and structural changes have been documented. Chromosome 14 in particular has been involved in translocations to several chromosomes, including t(11;14), t(8;14) and t (14;18). In addition to these translocations, acquisition of miscellaneous chromosomal fragments and unidentified markers (UMARS) is very frequent. Gains and losses of numerous chromosomes have also been noted. The current report summarises a preliminary analysis of a large study of 331 bone marrow specimens from 262 patients with multiple myeloma, studied at the University of Arizona.

Keywords

Leukemia Heparin Oncol Myeloma Amyloidosis 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Brian G. M. Durie
    • 1
  • Elizabeth E. Vela
    • 1
  • Valerie Baum
    • 2
  1. 1.Department of Haematology, Charing Cross and Westminster Medical SchoolUniversity of London, Charing Cross HospitalLondon W6UK
  2. 2.College of MedicineThe Arizona Cancer CenterTucsonUSA

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