Cytogenetic Abnormalities in Multiple Myeloma
Cytogenic studies in multiple myeloma have been very difficult because of the predominantly low proliferative activity in this disease (1-7). In the series reported to date the most commonly affected chromosomes have been chromosomes 1 and 14: a variety of translocations and structural changes have been documented. Chromosome 14 in particular has been involved in translocations to several chromosomes, including t(11;14), t(8;14) and t (14;18). In addition to these translocations, acquisition of miscellaneous chromosomal fragments and unidentified markers (UMARS) is very frequent. Gains and losses of numerous chromosomes have also been noted. The current report summarises a preliminary analysis of a large study of 331 bone marrow specimens from 262 patients with multiple myeloma, studied at the University of Arizona.
KeywordsLeukemia Heparin Oncol Myeloma Amyloidosis
Unable to display preview. Download preview PDF.
- 9.Harnden GD, Jensen JT (eds) (1985): An international system for human cytogenetic nomenclature. Basel, Switzerland, S. Karges.Google Scholar
- 13.Spier C, Durie BGM, Grogan TM, Richter LC, Vela E, Frutiger Y, Rangel CS (May 1990): T cell antigen positive multiple myeloma. Mod Path, in press.Google Scholar
- 15.Durie B, Baum V, Vela E, Mundy G (1986): Abnormalities of chromosome 6q and osteoclast activating factor production in multiple myeloma. Blood 68:208A (abstr).Google Scholar