Pathologic Evidence of Myocardial Damage Following Acute Brain Injuries

  • G. Baroldi


In one of the first reports, in 1969, Connor described two possibly linked myocardial lesions found in 8% and 9%, respectively, of 231 neurosurgical autopsies as “myocytolysis” and “fuchsinophilic degeneration”. These lesions were mainly found in cases with intracranial hemorrhage [1]. Similar morphologic findings have generally been ascribed to adrenergic overstimulation due to stimuli from specific areas of the brain and nervous system [2]. It is now clear that these two lesions are simply different chronologic aspects of one of the three main types of myocyte necrosis that are characterized by different structural, biochemical, and functional changes [3–5].


Myocardial Damage Interventricular Septum Myocardial Necrosis Acute Brain Injury Pathologic Evidence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Connor RCR (1969) Focal myocytolysis and fuchsinophilic degeneration of the myocardium of patient dying with various brain lesions. Ann NY Acad Sci 156: 261–270PubMedCrossRefGoogle Scholar
  2. 2.
    Levine SR, Patel VM, Welch KMA, Skinner JE (1989) Are heart attacks really brain attacks? In: Furlan A J (ed) The heart and stroke. Springer, Berlin Heidelberg New York, p 185Google Scholar
  3. 3.
    Baroldi G (1975) Different types of myocardial necrosis in coronary heart disease: a pathophysiological review of their functional significance. Am Heart J 89: 742–752PubMedCrossRefGoogle Scholar
  4. 4.
    Baroldi G (1988) Anatomy and quantification of myocardial cell death. In: Jasmin G (ed) Kinetics and patterns of necrosis. Methods Achiev Exp Pathol 13: 87Google Scholar
  5. 5.
    Baroldi G (1991) Morphological forms of myocardial necrosis related to myocardial cell function. In: Silver MD (ed) Cardiovascular pathology, 2nd edn. Churchill Livingston, New YorkGoogle Scholar
  6. 6.
    Todd GL, Baroldi G, Pieper GM, Clayton F, Eliot RS (1985) Experimental catecholamine- induced myocardial necrosis. I Morphology, quantification and regional distribution of acute contraction band lesions. J Mol Cell Cardiol 17: 317–338PubMedCrossRefGoogle Scholar
  7. 7.
    Todd GL, Baroldi G, Pieper GM, Clayton FC, Eliot RS (1985): Experimental catecholamine- induced myocardial necrosis. II Temporal development of isoproterenol-induced contraction band lesions correlated with ECG, hemodynamic and biochemical changes. J Mol Cell Cardiol 17: 647–656PubMedCrossRefGoogle Scholar
  8. 8.
    Silver MD, Baroldi G, Mariani F (1985) The relationship between acute occlusive coronary thrombi and myocardial infarction studied in 100 consecutive patients. Circulation 61: 219–277CrossRefGoogle Scholar
  9. 9.
    Baroldi G, Silver MD, Lixfeld W, McGregor DC (1977) Irreversible myocardial damage resembling catecholamine necrosis secondary to acute coronary occlusion in dogs: its prevention by propranolol. J Mol Cell Cardiol 9: 687–691PubMedCrossRefGoogle Scholar
  10. 10.
    Baroldi G, Falzi G, Mariani F (1979) Sudden coronary death. A postmortem study in 208 selected cases compared to 97 control subjects. Am Heart J 98: 20–31PubMedCrossRefGoogle Scholar
  11. 11.
    Baroldi G (1985) Pathology and mechanisms of sudden death. In: Hurst JW (ed) The heart, 6th edn. McGraw-Hill, New York p 529Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • G. Baroldi
    • 1
    • 2
    • 3
    • 4
  1. 1.Department of Cardiology “De Gasperis”Institute of Clinical Physiology CNRMilanItaly
  2. 2.Niguarda HospitalMilanItaly
  3. 3.Institute of Biomedical SciencesMedical School University of MilanMilanItaly
  4. 4.Department of Pathologic AnatomySacco HospitalMilanItaly

Personalised recommendations