Eye and Ear pp 149-155 | Cite as

Auricular Chondritis, Rat

  • Taisan Chiu
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


The gross appearance of experimentally induced lesions resembles that of naturally occurring ones. The lesions are seen in both ears. In the early stages of the natural disease the affected ears show no clinically detectable abnormality. Slight focal nodular or diffuse swelling and thickening, with or without erythema, develops as the lesions progress. These signs may partially or completely disappear. Nodule size and thickening increase up to a certain point and then stop without further change. The thickness of the ears ranges up to many times normal (Fig. 131). Subsequently, the ears become irregularly thickened (Fig. 132), white, firm, nodular, and droopy (Fig. 133) or remarkably deformed and misshapen (Fig. 134), resembling “cauliflower” or “wrestler” ears in man. Generally, there is no apparent change on the surface of the skin of the affected pinnae but, in some rats, the skin may be scaly, alopercic, or ulcerated.


Chondritis external ear auricular cartilage inflammation 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Chiu T, Lee KP (1984) Auricular chondropathy in aging rats. Vet Pathol 21: 500–504PubMedGoogle Scholar
  2. Cremer MA, Pitcock JA, Stuart JM, Kang AH, Townes AS (1981) Auricular Chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen. J Exp Med 154: 535–540PubMedCrossRefGoogle Scholar
  3. Enomoto A, Harada T, Maita K, Shirasu Y (1983) Auricular cystic lesions of the external ear in Sprague- Dawley rats. Jpn J Vet Sci 45: 695–698CrossRefGoogle Scholar
  4. Homma S, Matusmoto T, Abe H, Fukuda Y, Nagano M, Suzuki M (1984) Relapsing polychondritis. Pathological and immunological findings in an autopsy case. Acta Pathol Jpn 34:1137–1146PubMedGoogle Scholar
  5. Michet CJ Jr., McKenna CH, Luthra HS, O’Fallon WM (1986) Relapsing polychondritis. Survival and predictive role of early manifestations. Ann Intern Med 104: 74–78PubMedGoogle Scholar
  6. Linck G, Porte A, Mantz JM, Tempe JD, Jaeger A, Hauber C, Batzenschlager A (1981) Light and electron microscopic study of ear cartilage in a case of relapsing polychondritis evolving under corticoid treatment. Virchows Arch [Pathol Anat] 391: 301–308CrossRefGoogle Scholar
  7. McCune WJ, Schiller AL, Dynesius-Trentham RA, Trebtham DE (1982) Type II collagen-induced auricular chondritis. Arthritis Rheum 25:266–273PubMedCrossRefGoogle Scholar
  8. McEwen BJ, Barsoum NJ (1990) Auricular chondritis in Wistar rats. Lab Anim 24:280–283PubMedCrossRefGoogle Scholar
  9. Prieur DJ, Young DM, Counts DF (1984) Auricular chondritis in fawn hooded rats. A spontaneous disorder resembling that induced by immunization with type II collagen. Am J Pathol 116: 69–76PubMedGoogle Scholar
  10. Stuart JM, Townes AS, Kang AH (1982) The role of collagen autoimmunity in animal models and human diseases. J Invest Dermatol 79 [Suppl 1]: 121S–127SPubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Taisan Chiu

There are no affiliations available

Personalised recommendations