Eye and Ear pp 16-20 | Cite as

Calcification of the Cornea, Mouse and Rat

  • William W. Carlton
  • James A. Render
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Corneal calcification results in opacification, with the size of the opacity depending upon the extent of the calcification. It may appear as small, pale spots or as an opacity of geometric shape (Taradach and Greaves 1984), or it may be diffuse. Slight calcification produces a slight turbidity, more substantial focal deposits appear as gray dots beneath the corneal epithelium, and larger deposits cause the cornea to be chalky white.


Band keratopathy 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Economon JW, Silverstein AM, Zimmerman LE (1963) Band keratopathy in a rabbit colony. Invest Ophthalmol 2:361–368PubMedGoogle Scholar
  2. Fabian RJ, Band JM, Drobeck HP (1967) Induced corneal opacities in the rat. Br J Ophthalmol 51:124–129PubMedCrossRefGoogle Scholar
  3. Fine BS, Berkow JW, Fine S (1968) Corneal calcification. Science 162:129–130PubMedCrossRefGoogle Scholar
  4. Huang LH, Sery TW (1971) Corneal degeneration in a congenitally diabetic inbred strain of mouse. Br J Ophthalmol 55:266–271PubMedCrossRefGoogle Scholar
  5. Klintworth GK (1982) Degenerations, depositions and miscellaneous reactions of the cornea, conjunctiva and sclera. In: Garner A, Klintworth GK (eds) Patho-biology of ocular disease. Dekker. New York, pp 1431–1475Google Scholar
  6. Mittl R, Galin MA, Opperman W, Camerini-Davalas RA, Spiro D (1970) Corneal calcification in spontaneously diabetic mice. Invest Ophthalmol 9: 137–145PubMedGoogle Scholar
  7. Obenberger J, Ocumpaugh DE, Cubberly MG (1969) Experimental corneal calcification in animals treated with dihydrotachysteral. Invest Ophthalmol 8: 467–474PubMedGoogle Scholar
  8. Ocumpaugh DE, Obenberger J (1970) Experimental corneal calcification: a radioautographic and histo- chemical study. Clin Orthop 69:1691–171Google Scholar
  9. Porter R, Crombie AL (1973) Corneal and conjunctival calcification in chronic renal failure. Br J Ophthalmol 57:339–343PubMedCrossRefGoogle Scholar
  10. Selye H, Dieudonne JM, Veilleux R (1962) A calciphy- lactic syndrome affecting the skeletal muscles, the salivary gland and the eyes. Exp Med Sur g 20: 185–193Google Scholar
  11. Taradach C, Greaves P (1984) Spontaneous eye lesions in laboratory animals: incidence in relation to age. CRC Crit Rev Toxicol 12:121–141CrossRefGoogle Scholar
  12. Van Winkle TJ, Balk MW (1986) Spontaneous corneal opacities in laboratory mice. Lab Anim Sci 36: 248–255PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • William W. Carlton
  • James A. Render

There are no affiliations available

Personalised recommendations