Eye and Ear pp 101-107 | Cite as

Herpesvirus Infection, Experimental, Eye, Mouse

  • Sally S. Atherton
  • Herbert E. Whiteley
  • John A. Shadduck
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Following inoculation of herpes simplex virus, type 1, KOS strain (HSV-1), into the anterior chamber of one eye of a BALB/c mouse, an interesting pattern of bilateral ocular disease is observed. In the injected eye, there is massive inflammation of the anterior segment which results in the loss of the anterior chamber and destruction of the associated anterior segment structure (iris, ciliary body). The posterior segment of the inoculated eye remains relatively uninvolved in the inflammatory process and exhibits only mild inflammation of the vitreous chamber with preservation of the retinal architecture. In contrast, the uninoculated eye displays the opposite pattern of disease; the retina of this eye is destroyed while the anterior segment is preserved (Whittum et al. 1984). Two temporally distinct waves of virus are recovered from the uninoculated eye.


HSV-1 chorioretinitis HSV-1 retinal necrosis 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Anderson JR, Field HJ (1984) An animal model of ocular herpes. Keratitis, retinitis and cataract in the mouse. Br J Exp Pathol 65: 283–297PubMedGoogle Scholar
  2. Atherton SS, Streilein JW (1987a) Virus-specific DTH prevents contralateral retinitis following intracameral inoculation of HSV-2. Curr Eye Res 6:133–139PubMedCrossRefGoogle Scholar
  3. Atherton SS, Streilein JW (1987b) Two waves of virus following anterior chamber inoculation of HSV-1. Invest Ophthalmol Vis Sci 28: 571–579PubMedGoogle Scholar
  4. Cousins SW, Gonzalez A, Atherton SS (1989) Herpes simplex retinitis in the mouse: clinicopathologic correlations. Invest Ophthalmol Vis Sci 30:1485–1494PubMedGoogle Scholar
  5. Culbertson WW, Blumenkranz MS, Pepose JS, Stewart JA, Curtin VT (1986) Varicella zoster is a cause of the acute retinal necrosis syndrome. Ophthalmology 93: 559–569PubMedGoogle Scholar
  6. Dix RD, Stewart RV, Culbertson W, Atherton SS, Vann V, Miller D, Lewis ML (1988) Clinical association of herpes simplex virus type I (HSV-1) with acute retinal necrosis. Invest Ophthalmol Vis Sci [Suppl] 29:159Google Scholar
  7. Freeman WR, Thomas EL, Rao NA, Pepose JS, Trousdale MD, Howes EL, Nadel AJ, Mines JA, Bowe B (1986) HamasaDemonstration of herpes group virus in active retinal necrosis syndrome. Am J Ophthalmol 102: 701–709PubMedGoogle Scholar
  8. Hamasaki DI, Dix RD, Atherton SS (1988) Bilateral alterations of the ERG and retinal histology following unilateral HSV-L inoculation. Invest Ophthalmol Vis Sci 29:1242–1254PubMedGoogle Scholar
  9. Holland GN, Togni BI, Briones OC, Dawson CR (1987) A microscopic study of herpes simplex virus retinopathy in mice. Invest Ophthalmol Vis Sci 28: 1181–1190PubMedGoogle Scholar
  10. Kielty D, Cousins SW, Atherton SS (1987) HSV-L retinitis and delayed hypersensitivity in DBA/2 and C57BL/6 mice. Invest Ophthalmol Vis Sci 28: 1994–1999PubMedGoogle Scholar
  11. Olson RM, Holland GN, Goss SJ, Bowers WD, Meyers-Elliot RH (1987) Routes of viral spread in the von Szily model of herpes simplex virus retinopathy. Curr Eye Res 6: 59–62PubMedCrossRefGoogle Scholar
  12. Peiffer RL Jr, Dekker CD, Siegel FL (1983) Ocular lesions in mice following intracerebral injection of herpes simplex virus type 1. Invest Ophthalmol Vis Sci 24:1070–1078PubMedGoogle Scholar
  13. Pepose JS, Whittum-Hudson JA (1987) An immuno- genetic analysis of resistance to herpes simplex versus retinitis in inbred strains of mice. Invest Ophthalmol Vis Sci 28:1549–1552PubMedGoogle Scholar
  14. Streilein JW, Atherton SS, Vann V (1987) A critical role for ACAID in the distinctive pattern of retinitis that follows anterior chamber inoculation of HSV-L Curr Eye Res 6:127–131PubMedCrossRefGoogle Scholar
  15. Whittum JA, Niederkorn JY, McCulley JP, Streilein JW (1983) Intracameral inoculation of herpes simplex virus type 1 induces anterior chamber associated immune deviation. Curr Eye Res 2: 691–697CrossRefGoogle Scholar
  16. Whittum JA, McCulley JP, Niederkorn JY, Streilein JW (1984) Ocular disease induced in mice by anterior chamber inoculation of herpes simplex virus. Invest Ophthalmol Vis Sci 25:1065–1073PubMedGoogle Scholar
  17. Whittum-Hudson JA, Pepose JS (1987) Immunologic modulation of virus-induced pathology in a murine model of acute herpetic retinal necrosis. Invest Ophthalmol Vis Sci 28:1541–1548PubMedGoogle Scholar
  18. Whittum-Hudson JA, Farazdaghi M, Prendergast RA (1985) A role for T lymphocytes in preventing experimental herpes simplex virus type 1-induced retinitis. Invest Ophthalmol Vis Sci 26:1524–1532PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Sally S. Atherton
  • Herbert E. Whiteley
  • John A. Shadduck

There are no affiliations available

Personalised recommendations