Skip to main content

Paternity Analysis in a Deficient Family by DNA Profiling (Single-Locus and Multi-Locus Probes)

  • Chapter
DNA — Technology and Its Forensic Application
  • 186 Accesses

Abstract

With classical analytical methods without HLA typing, cases of disputed paternity are problematic when the putative father is not available for analysis. Due to the small number of distinguishable alleles per system, exclusions from paternity are relatively rare. Moreover, they have to be taken with care, since the assumed descent of the putative father may be incorrect When only one paternal grandparent is available for analysis, it is impossible to derive any exclusion. HLA analysis improves the probability of exclusion, but the number of analysable loci is limited and the loci are linked.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Smith JC, Anwar R, Riley J, Jenner D, Markham AF (1990) Highly polymorphic minisatellite sequences: allele frequencies and mutation rates for five locus-specific probes in a Caucasian population. J Forensic Sci Soc 30:19–32

    Article  PubMed  CAS  Google Scholar 

  2. Jeffreys AJ, Wilson V, Thein SL (1985) Hypervariable ‘minisatellite’ regions in human DNA. Nature 314:67–73

    Article  PubMed  CAS  Google Scholar 

  3. Jeffreys AJ, Wilson V, Thein SL (1985) Individual-specific ‘fingerprints’ of human DNA. Nature 316:76–79

    Article  PubMed  CAS  Google Scholar 

  4. Schacker U, Schneider PM, Holtkamp B, Bohnke E, Fimmers R, Sonnebom HH, Rittner C (1990) Isolation of the DNA minisatellite probe MZ 1.3 and its application to DNA ‘fingerprinting’ analysis. Forensic Sci Int 44:209–224

    Article  PubMed  CAS  Google Scholar 

  5. Gertdler SJ, Burchell JM, Duhig T, Lamport D, White R, Parker M, Taylor-Papadimitriou J (1987) Cloning of partial cDNA encoding differentiation and tumor-associated mucin glycoprotein expressed by human mammary epithelium. Proc Natl Acad Sci USA 84:6060–6064

    Article  Google Scholar 

  6. Dykes DD (1988) The use of biotinylated DNA probes in parentage testing: Non-isotopic labelling and non-toxic extraction. Electrophoresis 9:359–368

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Iten, E., Pflugshaupt, R. (1991). Paternity Analysis in a Deficient Family by DNA Profiling (Single-Locus and Multi-Locus Probes). In: Berghaus, G., Brinkmann, B., Rittner, C., Staak, M. (eds) DNA — Technology and Its Forensic Application. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76632-9_22

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-76632-9_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-54035-9

  • Online ISBN: 978-3-642-76632-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics