Paternity Analysis in a Deficient Family by DNA Profiling (Single-Locus and Multi-Locus Probes)
With classical analytical methods without HLA typing, cases of disputed paternity are problematic when the putative father is not available for analysis. Due to the small number of distinguishable alleles per system, exclusions from paternity are relatively rare. Moreover, they have to be taken with care, since the assumed descent of the putative father may be incorrect When only one paternal grandparent is available for analysis, it is impossible to derive any exclusion. HLA analysis improves the probability of exclusion, but the number of analysable loci is limited and the loci are linked.
KeywordsEDTA Agarose Citrate Electrophoresis Nylon
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