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The Use of Donor-Specific Bone Marrow to Induce Specific Allograft Unresponsiveness (Tolerance) in Adult Animals Transiently Immunosuppressed with Polyclonal Antilymphocyte Serum

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Abstract

It is a great pleasure and honor for me to speak on the use of polyclonal antilymphocyte serum and donor antigen, specifically donor-specific bone marrow, to produce specific unresponsiveness (tolerance) to allografted tissue and organs. This topic is especially significant in view of Prof. Walter Brendel’s early and pioneering interests in the uses of polyclonal antilymphocyte sera in tissue transplantation. This presentation is taken from a recent summary [1] by my colleagues and me in which we updated the use of polyclonal antilymphocyte serum and donor-specific bone marrow to induce unresponsiveness to tissue and organ allografts in several species.

Keywords

Renal Allograft Tolerance Induction Donor Bone Marrow Mixed Lymphocyte Culture Chronic Immunosuppression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin · Heidelberg 1991

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