Induction of Peripheral Tolerance to Class I MHC Alloantigens in Adult Mice

  • H. Wagner
  • K. Pfeffer
  • K. Heeg

Abstract

A major goal of transplantation immunology is to define gentle methods able to convert immune reactivity to transplantation antigens into a state of immune unresponsiveness. It is well known that this conversion is successful in neonates: introduction of foreign antigens into a developing immune system prevents the immune system from responding further to these antigens. Induction of unresponsiveness in the mature peripheral T cell pool, however, meets difficulties: receptor occupancy by antigens induces primarily sensitization rather than tolerance.

Keywords

Cyclosporin 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1991

Authors and Affiliations

  • H. Wagner
  • K. Pfeffer
  • K. Heeg

There are no affiliations available

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