Induction of Peripheral Tolerance to Class I MHC Alloantigens in Adult Mice
A major goal of transplantation immunology is to define gentle methods able to convert immune reactivity to transplantation antigens into a state of immune unresponsiveness. It is well known that this conversion is successful in neonates: introduction of foreign antigens into a developing immune system prevents the immune system from responding further to these antigens. Induction of unresponsiveness in the mature peripheral T cell pool, however, meets difficulties: receptor occupancy by antigens induces primarily sensitization rather than tolerance.
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