What We Have Learned from Highly Immunized Patients



I would like to begin by thanking Walter Brendel for initiating the Kitzbühel-Axams meetings. This talk is dedicated in his honour and in appreciation of what he has done. He has been in many ways a leader; he professionalised experimental surgery with the “big bang” machine as one of the many highlights, introduced us to xenotransplantation, but above all initiated these wonderful round table meetings on immunology. The recipe was as simple as it was brilliant: take some beautiful snow-covered mountains, mix them together, invite a lot of friends and ask them to talk about science. Most of these people have been involved in transplantation, but not all of them. We have heard talks about skin grafts in monkeys, about liver transplantation in pigs, and many, many other topics.


Live Donor Kidney Transplant Potential Kidney Donor Acceptable Mismatch CTLp Frequency UCLA Tissue Type Laboratory 
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  1. 1.
    Bradley BA, Klouda PT, Ray TC et al. (1985) Negative crossmatch selection of kidneys for highly sensitized patients. Transplant Proc 17: 2465–2466Google Scholar
  2. 2.
    Schafter AJ, Hasert K, Opelz G (1985) Collaborative transplant study crossmatch and antibody project. Transplant Proc 17: 2469–2471Google Scholar
  3. 3.
    Hendriks GFJ, de Lange P, D’Amaro J et al. (1985) Eurotransplant experience with highly immunized patients. Scand J Urol Nephrol 92: 81–86Google Scholar
  4. 4.
    Klouda PT, Ray TC, Kirkpatrick J et al. (1987) Graft survival in highly sensitized patients. Transplant Proc 19: 3744–3745PubMedGoogle Scholar
  5. 5.
    Claas FHJ, Gijbels Y, van der Velden-de Munck JJ et al. (1988) A special strategy to increase the chance of finding crossmatch negative kidneys for highly sensitized patients. Transplant Proc 20: 947–948PubMedGoogle Scholar
  6. 6.
    Owen RD, Wood HR, Foord AG (1954) Evidence for actively acquired tolerance to Rh antigens. Proc Natl Acad Sci USA 40: 420–424PubMedCrossRefGoogle Scholar
  7. 7.
    Streilein JW, Gruchella RS, Wood P, Strome P (1982) Active clonal deletion in neonatal H2 tolerance. Ann NY Acad Sci 392: 276–290PubMedCrossRefGoogle Scholar
  8. 8.
    Streilein JW, Gruchella RS (1981) Analysis of neonatally induced tolerance of H-2 allo antigens. I Adoptive transfer indicates that tolerance of class I and class II antigens is maintained by distinct mechanisms. Immunogenetics 12: 161–173Google Scholar
  9. 9.
    Zhang L, Guang Li S, Vandekerckhove B, Termijtelen A, van Rood JJ, Claas, FHJ (1989) Analysis of cytotoxic T cell precursor directed against individual HLA-A and -B alloantigens. J Immunol Methods 121: 39–45PubMedCrossRefGoogle Scholar
  10. 10.
    Cicciarelli J (1989) Living donor kidney transplants. In: Terasaki PI (ed) Clinical transplants 1988. UCLA Tissue Typing Laboratory, Los Angeles, pp 293Google Scholar
  11. 11.
    Takiff H, Cook DJ, Himaya NS, Mickey MR, Terasaki PI (1988) Dominant effect of histocompatibility on ten-year kidney transplant survival. Transplantation 45: 410–415PubMedCrossRefGoogle Scholar
  12. 12.
    Chardonnens X, Jeannet M (1980) Immunobiology of pregnancy: evidence for a fetal immune response against the mother(?). Tissue Antigens 15: 401–406PubMedGoogle Scholar
  13. 13.
    Ivanyi P, Démant P (1964) Prolonged survival of maternal skin grafts in newborn rabbits. Folia Biol 11: 321–323Google Scholar
  14. 14.
    Kois WE, Campbell DA, Lorber MI, Sweeton JC, Dafoe DC (1984) Influence of breastfeeding on subsequent reactivity to a related renal allograft. J Surg Res 37: 89–93PubMedCrossRefGoogle Scholar
  15. 15.
    Kalia A, Dobbins JG, Brouhard BH, Travis L (1988) Sex of the parental donor and cellular rejection of renal allografts in children. Transplantation 46: 70–73PubMedCrossRefGoogle Scholar
  16. 16.
    Warram JH, Krolewski AS, Kahn CR (1988) Determinants of IDDM and perinatal mortality in children of diabetic mothers. Diabetes 37: 1328–1334PubMedCrossRefGoogle Scholar
  17. 17.
    Claas FHJ, Gijbels Y, van der Velden-de Munck J, van Rood JJ (1988) Induction of B cell unresponsiveness to noninherited maternal HLA antigens during fetal life. Science 241: 1815–1817Google Scholar

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© Springer-Verlag Berlin · Heidelberg 1991

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