Micrometastasis of Epithelial Tumors: Signum Mortis for the Patient or the Achilles’ Heel of Cancer?
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Remembering Walter Brendel’s long-standing enthusiasm for tumor immunology, we have chosen a topic dealing with our most recent approach to identifying and defining micrometastatic cancer cells in bone marrow. When we met Walter for the first time in the mid-1960s, he was fascinated, as were many of us, by the idea that tumors might follow the same rules of acceptance and rejection as allografts. At that time we were not fully aware of the common history of tumor immunology and transplantation immunology, which had cross-fertilized each other already for some time. We are fortunate that Avrion Mitchison is with us here as witness of the early days when Gorer in the search of tumor rejection antigens discovered the major histocompatibility complex of mice.
KeywordsMetastatic Cell Disseminate Tumor Cell Tumor Immunology Individual Tumor Cell Bone Marrow Micrometastasis
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